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| 1 | 乳腺囊内型乳头状癌显示文摘 | Collins L C Carlo V P Hwang H 魏兵(摘译) 步宏(审校) | 2006 | 临床与实验病理学杂志2006，22，5： | 38 |
| 2 | 反流性食管炎中埃索美拉唑比奥美拉唑更能促进病变愈合和症状缓解显示文摘 | Kahrilas PJ Falk GW Johnson DA Schmitt C Collins DW Whipple J D’Amino D Hamelin B Joelsson B 钟捷 | 2002 | 中华消化杂志2002，22，11： | 19 |
| 3 | Molecular targets in the treatment of alcoholic hepatitis显示文摘Alcohol related costs to health and society are high. One of the most serious complications of alcohol misuse to the individual is the development of alcoholic hepatitis (AH), a clinical syndrome of jaundice and progressive inflammatory liver injury in patients with a history of recent heavy alcohol use. It has a poor outcome and few existing successful therapies. The use of glucocorticoids in patients with severe AH is still controversial and there remains a group of patients with glucocorticoid-resistant disease. However, as our understanding of the pathogenesis of the condition improves there are opportunities to develop new targeted therapies with specific actions to control liver inflammation without having a detrimental effect on the immune system as a whole. In this article we review the molecular mechanisms of AH concentrating on the activation of the innate and adaptive immune response. We consider existing treatments including glucocorticoids, anti-tumor necrosis factor therapy and pentoxifylline and their limitations. Using our knowledge of the disease pathogenesis we discuss possible novel therapeutic approaches. New targets include pro-inflammatory cytokines such as interleukin (IL)-17, chemokines and their receptors (for example IL-8, CXCL9 and CXCR3) and augmentation of anti-inflam- matory molecules such as IL-10 and IL-22. And there is also future potential to consider combination therapy to selectively modulate the immune response and gain control of disease. | Ashwin D Dhanda Richard WL Lee Peter L Collins C Anne McCune | 2012 | World Journal of Gastroenterology2012，18，39： | 9 |
| 4 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 5 | The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing显示文摘前列腺癌症是全球癌症相关的死亡的一个领先的原因,但是试图改善诊断并且开发新奇治疗被重要耐心的异质惊讶。在最近的年里,到几百个前列腺瘤的下一代的定序的应用程序定义新奇分子的子类型并且描绘了位于疾病开始和前进下面的广泛的 genomic 错误。在诊所观察的异质是由与复杂性流行的一处分子的风景的 underpinned,现在是清楚的,在 genomic 重新整理和稀罕变化联合放大 transcriptomic 差异的地方。这评论把我们前列腺癌症 ‘ 的当前的理解; omic 的包括拷贝数字变化的哨兵角色, oncogenic 熔化基因, chromothripsis 的潜在的影响,和在定义联系变化的子类型的突破的成长光谱。增加的证据建议损害经常在特定的细胞的功能和发信号的小径上集成的那 genomic,还周期性的基因错误显得稀罕。因此,我们继续定义单个瘤染色体,是批评的,特别在他们的表示 transcriptome 的上下文。仅仅通过到瘤可变性罐头的瘤的改进描述,我们前进到精确治疗和个性化的肿瘤学的年龄。 | Alexander W Wyatt Fan Mo Yuzhuo Wang Colin C Collins | 2013 | Asian Journal of Andrology2013，15，3： | 5 |
| 6 | Is liver biopsy necessary in the management of alcoholic hepatitis?显示文摘Acute alcoholic hepatitis(AAH)is characterised by deep jaundice in patients with a history of heavy alcohol use,which can progress to liver failure.A clinical diagnosis of AAH can be challenging to make in patients without a clear alcohol history or in the presence of risk factors for other causes of acute liver failure.Other causes of acute on chronic liver failure such as sepsis or variceal haemorrhage should be considered.Liver biopsy remains the only reliable method to make an accurate diagnosis.However,there is controversy surrounding the use of liver biopsy in patients with AAH because of the risks of performing a percutaneous biopsy and limitations in access to transjugular biopsy.We review the existing literature and find there are few studies directly comparing clinical and histological diagnosis of AAH.In the small number of studies that have been conducted the correlation between a clinical and histological diagnosis of AAH is poor.Due to this lack of agreement together with difficulties in accessing transjugular liver biopsy outside tertiary referral centres and research institutions,we cannot advocate universal biopsy for AAH but there remains a definite role for liver biopsy where there is clinical diagnostic doubt or dual pathology.Italso adds value in a clinical trial context to ensure a homogeneous trial population and to further our understanding of the disease pathology.Further prospective studies are required to determine whether non-invasive markers can be used to accurately diagnose AAH. | Ashwin D Dhanda Peter L Collins C Anne McCune | 2013 | World Journal of Gastroenterology2013，19，44： | 4 |
| 7 | Next generation patient-derived prostate cancer xenograft models显示文摘对为前列腺癌症的更有效的治疗学的途径有批评需要。然而,在这个区域的研究被缺乏严重妨碍了临床上相关,在疾病的 vivo 模型试验性。这评论特别地基于 patients’ 的 subrenal 囊 grafting 集中于前列腺癌症异种皮移植模型的发展;进 nonobese 糖尿病 / 严重的肿瘤组织联合了 immunodeficient (NOD/SCID ) 老鼠。这种技术允许可移植的、导出病人的癌症织物异种皮移植线的成功的开发从不仅好攻击变形,而且从局部性的前列腺癌症纸巾。异种皮移植被发现了保留原来的恶意的关键生物性质,包括组织病理学说、分子的特征,肿瘤异质,对雄激素脱离的反应和变形能力。因此,他们是高度临床上相关并且在细胞、分子的层次,为个性化的癌症治疗屏蔽的药和现出症状之前的潜的药为前列腺癌症前进的研究提供珍贵工具测试的功效;特别当模型的一块面板习惯于盖子时许多疾病。这些异种皮移植模型能因此被看作前列腺癌症的下一代的模型。 | Dong Lin Hui Xue Yuwei Wang Rebecca Wu Akira Watahiki Xin Dong Hongwei Cheng Alexander W Wyatt Colin C Collins Peter W Gout Yuzhuo Wang | 2014 | Asian Journal of Andrology2014，16，3： | 4 |
| 8 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 9 | A practical method for calculating largest Lyapunov exponents in from small data set显示文摘 | Rosenstein M T Collins J J De Luca C J | 1993 | Physica D1993，65，12： | 2 |
| 10 | Prostate cancer metastasis-driving genes: hurdles and potential approaches in their identification显示文摘变形前列腺癌症当前是医不好的。转移被认为在 nonmetastatic 前列腺癌症织物从变化导致特定的驾驶转移的基因的表示,导致设置了在运动的变形过程的激活的下游的基因的串联。如此的基因能潜在地为疾病的改进管理用作有效治疗学的目标。他们能被基因表示侧面的比较分析识别导出病人变形并且指出基因出现的 nonmetastatic 前列腺癌症纸巾改变了表示,由决定如此的基因的 silencing 是否能导致变形性质的抑制列在后面。在这条途径遇到的各种各样的障碍被讨论,包括(i) 对的需要临床上相关, nonmetastatic 和变形前列腺癌症纸巾象 patients’ 的异种皮移植那样;前列腺癌症经由 subrenal 囊 grafting 技术发展了并且(ii ) 在为鉴定的当前可得到的方法论的限制掌握规章的基因。 | Yan Ting Chiang Peter W Gout Colin C Collins Yuzhuo Wang | 2014 | Asian Journal of Andrology2014，16，4： | 2 |
| 11 | Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc显示文摘The depletion of chondroitin sulfates(CSs)within the intervertebral disc(IVD)during degenerative disc disease(DDD)results in a decrease in tissue hydration,a loss of fluid movement,cell apoptosis,a loss of nerve growth inhibition and ultimately,the loss of disc function.To date,little is known with regards to the structure and content of chondroitin sulfates(CSs)during IVD ageing.The behavior of glycosaminoglycans(GAGs),specifically CSs,as well as xylosyltransferase I(XT-I)and glucuronyltransferase I(GT-I),two key enzymes involved in CS synthesis as a primer of glycosaminoglycan(GAG)chain elongation and GAG synthesis in the nucleus pulposus(NP),respectively,were evaluated in a bovine ageing IVD model.Here,we showed significant changes in the composition of GAGs during the disc ageing process(6-month-old,2-year-old and 8-year-old IVDs representing the immature to mature skeleton).The CS quantity and composition of annulus fibrosus(AF)and NP were determined.The expression of both XT-I and GT-I was detected using immunohistochemistry.A significant decrease in GAGs was observed during the ageing process.CSs are affected at both the structural and quantitative levels with important changes in sulfation observed upon maturity,which correlated with a decrease in the expression of both XT-I and GT-I.A progressive switch of the sulfation profile was noted in both NP and AF tissues from 6 months to 8 years.These changes give an appreciation of the potential impact of CSs on the disc biology and the development of therapeutic approaches for disc regeneration and repair. | Estelle C Collin Oliver Carroll Michelle Kilcoyne Marianna Peroglio Eugene See Doris Hendig Mauro Alini Sibylle Grad Abhay Pandit | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 2 |
| 12 | A practical method for calculating largest Lyapunov exponents from small data sets显示文摘 | Rosenstein M T Collins J J Deluca C J | 1993 | Physica D1993，65，1： | 2 |
| 13 | CD133,a novel marker for human prostatic epithelial stem cells显示文摘 | Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T | 2004 | J Cell Sci2004，117，16： | 1 |
| 14 | The Barthel ADL Index:a reliability study显示文摘 | Wade DT Davies S | 1988 | Int Disability Study1988，10，： | 1 |
| 15 | The Barthel ADL Index:a standard measure of physical disability显示文摘 | Wade DT Collin C | 1988 | Int Disabil Stud1988，10，： | 1 |
| 16 | A period stochastic reso- nance in excitable systems显示文摘 | Collins J J Chow C C Infiaoff T T | 1995 | Physics Review E1995，52，3： | 1 |
| 17 | Determinants of individual engagement in knowledge sharing显示文摘 | Cabrera A Collins W C Salgado J F | 2006 | International Journal of HumanResource Management2006，17，2： | 1 |
| 18 | A practical method for calculating largest Lyapunov exponents from small data sets显示文摘 | ROSENSTEIN M T COLLINS J J DE LUCA C J | 1993 | Physica D1993，65，1： | 1 |
| 19 | Deletion of the FHIT gene in neoplastic and invasive cervical lesions is related to high-risk HPV infection but is independent of histopathological features显示文摘 | Butler D Collins C Mabruk M | 2000 | J Pathol2000，192，： | 1 |
| 20 | Hippocampal synaptic plasticity in miceoverexpressing an embryonic subunit of the NMDA receptor显示文摘 | Okabe S Collin C Auerbach JM | 1998 | J Neurosci1998，18，： | 1 |
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