|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Magnetic resonance imaging may predict deep remission in patients with perianal fistulizing Crohn's disease显示文摘AIM To evaluate the imaging course of Crohn's disease(CD) patients with perianal fistulas on long-term maintenance anti-tumor necrosis factor(TNF)-α therapy and identify predictors of deep remission.METHODS All patients with perianal CD treated with anti-TNF-α therapy at our tertiary care center were evaluated by magnetic resonance imaging(MRI) and clinical assessment. Two MR examinations were performed: at initiation of anti-TNF-α treatment and then at least 2 years after. Clinical assessment(remission, response and non-response) was based on Present's criteria. Rectoscopic patterns, MRI Van Assche score, and MRI fistula activity signs(T2 signal and contrast enhancement) were collected for the two MR examinations. Fistula healing was defined as the absence of T2 hyperintensity and contrast enhancement on MRI. Deep remission was defined as the association of both clinical remission, absence of anal canal ulcers and healing on MRI. Characteristics and imaging patterns of patients with and without deep remission were compared by univariate and multivariate analyses.RESULTS Forty-nine consecutive patients(31 females and 18 males) were included. They ranged in age from 14-70 years(mean, 33 years). MRI and clinical assessment were performed after a mean period of exposure to anti-TNF-α therapy of 40 ± 3.7 mo. Clinical remission, response and non-response were observed in 53.1%, 20.4%, and 26.5% of patients, respectively. Deep remission was observed in 32.7% of patients. Among the 26 patients in clinical remission, 10 had persisting inflammation of fistulas on MRI(T2 hyperintensity, n = 7; contrast enhancement, n = 10). Univariate analysis showed that deep remission was associated with the absence of rectal involvement and the absence of switch of anti-TNF-α treatment or surgery requirement. Multivariate analysis demonstrated that only the absence of rectal involvement(OR = 4.6; 95%CI: 1.03-20.5) was associated with deep remission.CONCLUSION Deep remission is achieved in approximately one third of patients on maintenance anti-TNF-α therapy. Absence of rectal involvement is predictive of deep remission. | Lucie Thomassin Laura Armengol-Debeir Cloé Charpentier Valerie Bridoux Edith Koning Guillaume Savoye Céline Savoye-Collet | 2017 | World Journal of Gastroenterology2017，23，23： | 5 |
| 2 | Serum amyloid P component and C-reactive protein mediate phagocytosis through murine FcγRs显示文摘 | Mold C Gresham H D Du Clos T W | 2001 | J Immunol2001，166，： | 2 |
| 3 | A study of nonblocking switching fabric networks 显示文摘 | C Clos | 1953 | BSTJ1953，32，5： | 1 |
| 4 | A study of nonblocking switching networks显示文摘 | Clos C | | 0，，02： | 1 |
| 5 | A Study of Non-Blocking Switching Networks 显示文摘 | Clos C | 1953 | Bell Systems Technical Journal1953，，： | 1 |
| 6 | Regulation of complement activation by C-reactive protein显示文摘 | Mold C Gewurz H Du Clos T W | 1999 | Immunopharmacology1999，42，： | 1 |
| 7 | Regulation of complement activationby C-reactiveprotein显示文摘 | Mold C Gewurz H Du Clos TW | 1999 | Immunopharmacology1999，42，13： | 1 |
| 8 | Regulation of complement activation by c-reactive protein显示文摘 | Mold C Gewurz H Du Clos TW | 1999 | Immuno- phamacology1999，42，： | 1 |
| 9 | Regulation of complement activation by C- reactive protein显示文摘 | Mole C Gewurz H Du Clos TW | 1999 | Immunopharmacology1999，42，： | 1 |
| 10 | C-reactive protein: Ligands, receptors and role in inflammation显示文摘 | MARNELL L MOLD C DU CLOS T W | 2005 | Clin Immunol2005，117，： | 1 |
| 11 | Protection from Streptococcus pneumoniae infeetion by C-reaetive protein and natural antibody requires complement but not Fc gamma receptors显示文摘 | Mold C Rodic-Polic B Du Clos TW | 2002 | J Immunol2002，168，12： | 1 |
| 12 | A study of nonblocking switching networks显示文摘 | Clos C | 1953 | Bell System Technical Journal1953，32，2： | 1 |
| 13 | Recent advances in catalytic asymmetric reactions promoted by transition metal complexes显示文摘 | Ojima I Clos N Bastos C | 1989 | Tetrahedron1989，45，22： | 1 |
| 14 | A study of non-blocking switching networks显示文摘 | Clos C | 1953 | The Bell System Technical Journal1953，34，10： | 1 |
| 15 | Pentraxins,(CRP,SAP)in the process of complement activation and clearance of apoptotic bodies through Fc gamma receptors显示文摘 | Du Clos TW Mold C | | 0，，09： | 1 |
| 16 | regutation of complement activa- tion by erection protein显示文摘 | Mold C Gewurz H du Clos TW | 1999 | Immunopharmacology1999，42，13： | 1 |
| 17 | Regutation of complement activation by Crection protein显示文摘 | Mold C Gewurz H Du Clos TW | 1999 | Immunopharmacology1999，42，： | 1 |
| 18 | A study of non-blocking switching networks显示文摘 | Clos C | 1953 | Bell System Tech Journal1953，32，2： | 1 |
| 19 | C-reactive protein binding to murine leukoeytes requires Fc gamma receptors 显示文摘 | Stein MP Mold C Du Clos TW | 2000 | J Immunol2000，164，3： | 1 |
| 20 | C-reactive protein:anactivator of innate immunity and modulator of adaptive im-nunity 显示文摘 | Du Clos TW Mold C | 2004 | Inununol Res2004，30，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员