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| 1 | Pharmacokinetics and tolerability of single and multiple doses of ticagrelor in healthy Chinese subjects:an open-label,sequential,two-cohort,single-centre study显示文摘 | LI H BUTLER K YANG L | 2012 | Clin Drug Investig2012，32，： | 1 |
| 2 | Pharmacokinetics and tolerability of single and multiple doses of ti- cagrelor in healthy Chinese subjects: an open-label, sequential, two-cohort, single-centre study显示文摘 | Li H Butler K Yang L | 2012 | Clin Drug Investig2012，32，2： | 1 |
| 3 | Method for the determination of residues of carbamate insecticides by electron- capture gas chromatography显示文摘 | Butler LI McDonough LM | 1968 | Journal of Agricultural and Food Chemistry1968，16，： | 1 |
| 4 | Early Childhood Computer Experience and Cognitive Development a- mong Urban Low--Income Preschoolers 显示文摘 | Fish A M Li X MeCarrick K Butler S T Stanton B Bru- mitt G A Bhavnagri N P Holtrop T Partridge T | 2008 | Journal of Edu- cational Computing Research2008，38，1： | 1 |
| 5 | Pharmacokinetics and toler- ability of single and multiple doses of ticagrelor in healthy Chi- nese subjects显示文摘 | LI H BUTLER K YANG L | 2012 | Clin Drug lnvestig2012，32，2： | 1 |
| 6 | Single nucleotide polymorphism determination using primer extension and time-of-flight mass spectrometry 显示文摘 | Butler J M Tan Y | 1999 | Electrophoresis1999，20，： | 1 |
| 7 | Statin exposure is associated with decreased asthma related emergency department visits and oral corticosteroid use显示文摘 | Tse SM Li L Butler MG | 2013 | Am J Respir Crit Care Med2013，188，9： | 1 |
| 8 | Toward reimagining strategy research: Retrospection and prospection on the 2011AMR decade award article显示文摘 | Priem R L Butler J E Li S L | 2013 | Academy of Management Review2013，38，4： | 1 |
| 9 | Reliable genotyping of short tandem repeat loci without an allelic ladder using time-of-flight mass spectrometry显示文摘 | Butler JM Li J Shaler TA | 1998 | Int J Legal Med1998，112，： | 1 |
| 10 | Single nucleotide polymor- phism determination using primer extension and time-of-flight mass spectrometer显示文摘 | Li J Butler J M Tan Y P | 1999 | Electrophoresis1999，20，： | 1 |
| 11 | The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells显示文摘 | LI S BUTLER P WANG Y | 2002 | Proc Natl Acad Sci U S A2002，99，6： | 1 |
| 12 | Viable Transgenic Goats Derived from Skin Cells显示文摘 | Esmail Behboodi Erdogan Memili David T. Melican Margaret M. Destrempes Susan A. Overton Jennifer L. Williams Peter A. Flanagan Robin E. Butler Hetty Liem Li How Chen Harry M. Meade William G. Gavin Yann Echelard | 2004 | Transgenic Research2004，，3： | 1 |
| 13 | Rate sensitivity of shear-induced changes in the lateral diffusion of endothelial cell membrane lipids:A role for membrane perturbation in shear-induced MAPK activation 显示文摘 | BUTLER PJ TSOU TC LI JY | 2002 | Faseb J2002，16，2： | 1 |
| 14 | In vitro and in vivo characterization of erythrosin B and derivatives against Zika virus显示文摘Zika virus(ZIKV)causes significant human diseases without specific therapy.Previously we found erythrosin B,an FDA-approved food additive,inhibited viral NS2B−NS3 interactions,leading to inhibition of ZIKV infection in cell culture.In this study,we performed pharmacokinetic and in vivo studies to demonstrate the efficacy of erythrosin B against ZIKV in 3D mini-brain organoid and mouse models.Our results showed that erythrosin B is very effective in abolishing ZIKV replication in the 3D organoid model.Although pharmacokinetics studies indicated that erythrosin B had a low absorption profile,mice challenged by a lethal dose of ZIKV showed a significantly improved survival rate upon oral administration of erythrosin B,compared to vehicle control.Limited structure−activity relationship studies indicated that most analogs of erythrosin B with modifications on the xanthene ring led to loss or reduction of inhibitory activities towards viral NS2B−NS3 interactions,protease activity and antiviral efficacy.In contrast,introducing chlorine substitutions on the isobenzofuran ring led to slightly increased activities,suggesting that the isobenzofuran ring is well tolerated for modifications.Cytotoxicity studies indicated that all derivatives are nontoxic to human cells.Overall,our studies demonstrated erythrosin B is an effective antiviral against ZIKV both in vitro and in vivo. | Zhong Li Jimin Xu Yuekun Lang Xiangmeng Wu Saiyang Hu Subodh Kumar Samrat Anil M.Tharappel Lili Kuo David Butler Yongcheng Song Qing-Yu Zhang Jia Zhou Hongmin Li | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 15 | 高血压与非高血压者收缩压与脑灌注的不同关系显示文摘越来越多的人认同高血压与脑血管损伤有关,但血压与脑血流的关系还不完全清楚。对脑灌注最佳的血压水平及治疗靶目标仍不明确。而且血压如何影响记忆的关键部位海马的灌注资料有限。 | Glodzik L Rusinek H Tsui W Pirraglia E Kim HJ Deshpande A Li Y Storey P Randall C Chen J Osorio RS Butler T Tanzi E McQuillan M Harvey P Williams SK Ogedegbe G Babb JS de Leon MJ 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，12： | 0 |
| 16 | Fluorine-containing drugs approved by the FDA in 2021显示文摘Nine new fluorine-containing drugs have been approved by the US Food and Drug Administration(FDA)in 2021,which are presented in this review article.These small molecular drugs feature aromatic fluorine,trifluoromethyl and chlorodifluoro groups.The therapeutic areas of these fluorine-containing drugs include multiple myeloma,lymphoma,HIV,chronic heart failure,chronic myeloid leukemia,(ANCA)-associated vasculitis,migraines,von Hippel-Lindau disease,and non-small cell lung cancer.The brief biological activities and the synthetic methods have been discussed in this review for each of these nine drugs. | Jingrui He Ziyi Li Gagan Dhawan Wei Zhang Alexander E.Sorochinsky Greg Butler Vadim A.Soloshonok Jianlin Han | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
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