2篇
您的检索式：作者名="Subodh Kumar Samrat"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | In vitro and in vivo characterization of erythrosin B and derivatives against Zika virus显示文摘Zika virus(ZIKV)causes significant human diseases without specific therapy.Previously we found erythrosin B,an FDA-approved food additive,inhibited viral NS2B−NS3 interactions,leading to inhibition of ZIKV infection in cell culture.In this study,we performed pharmacokinetic and in vivo studies to demonstrate the efficacy of erythrosin B against ZIKV in 3D mini-brain organoid and mouse models.Our results showed that erythrosin B is very effective in abolishing ZIKV replication in the 3D organoid model.Although pharmacokinetics studies indicated that erythrosin B had a low absorption profile,mice challenged by a lethal dose of ZIKV showed a significantly improved survival rate upon oral administration of erythrosin B,compared to vehicle control.Limited structure−activity relationship studies indicated that most analogs of erythrosin B with modifications on the xanthene ring led to loss or reduction of inhibitory activities towards viral NS2B−NS3 interactions,protease activity and antiviral efficacy.In contrast,introducing chlorine substitutions on the isobenzofuran ring led to slightly increased activities,suggesting that the isobenzofuran ring is well tolerated for modifications.Cytotoxicity studies indicated that all derivatives are nontoxic to human cells.Overall,our studies demonstrated erythrosin B is an effective antiviral against ZIKV both in vitro and in vivo. | Zhong Li Jimin Xu Yuekun Lang Xiangmeng Wu Saiyang Hu Subodh Kumar Samrat Anil M.Tharappel Lili Kuo David Butler Yongcheng Song Qing-Yu Zhang Jia Zhou Hongmin Li | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 2 | The main protease of SARS-CoV-2 downregulates innate immunity via a translational repression显示文摘Dear Editor,SARS-CoV-2 is the etiological cause of COVID-19.RIG-I-like receptor(RLR)signaling pathway appeared to be responsible for SARS-CoV-2 induced IFN,1 a major antiviral pathway.IFN deficiency2,3 was identified to be a significant risk factor of severe COVID-19,highlighting an important role of IFN in the defense against SARS-CoV-2 and in the pathogenesis of severe COVID-19. | Weifeng Liang Ming Gu Lingxiang Zhu Ziqi Yan Dominik Schenten Shelby Herrick Hongmin Li Subodh Kumar Samrat Jiapeng Zhu Yin Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员