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| 1 | Influence of a nucleotide oligomerization domain 1 (NOD1) polymorphism and NOD2 mutant alleles on Crohn's disease phenotype显示文摘AIM: To examine genetic variation of nucleotide oligomerization domain 1 (NOD1 ) and NOD2 ,their respective influences on Crohn's disease phenotype and gene-gene interactions. METHODS: (ND1+326561 ) NOD1 polymorphism and SNP8,SNP12 and SNP13 of NOD2 were analyzed in 97 patients and 50 controls. NOD2 variants were determined by reaction restriction fragment length polymorphism analysis. NOD1 genotyping and NOD2 variant confirmation were performed by specific amplification and sequencing. RESULTS: The distribution of NOD1 polymorphism in patients was different from controls (P = 0.045) and not altered by existence of NOD2 mutations. In this cohort,30.92% patients and 6% controls carried at least one NOD2 variant (P < 0.001) with R702W being the most frequent variant. Presence of at least one NOD2 mutation was inversely associated with colon involvement (9.09% with colon vs 36.4% with ileal or ileocolonic involvement,P = 0.04) and indicative of risk of penetrating disease (52.63% with penetrating vs 25.64% with non-penetrating or stricturing behavior,P = 0.02). L1007finsC and double NOD2 mutation conferred the highest risk for severity of disease (26.3% with penetrating disease vs 3.8% with non-penetrating or stricturing behavior presented L1007finsC,P = 0.01 and 21.0% with penetrating disease vs 2.5% with non-penentrating or stricturing behavior carried double NOD2 mutation,P = 0.007). Exclusion of patients with NOD2 mutations from phenotype/NOD1 -genotype analysis revealed higher prevalence of 11 genotype in groups of younger age at onset and colonic location. CONCLUSION: This study suggests population differences in the inheritance of risk NOD1 polymorphism and NOD2 mutations. Although no interaction between NOD1 -NOD2 was noticed,a relationship between disease location and Nod-like receptor molecules was established. | Elisabet Cantó Elena Ricart David Busquets David Monfort Esther García-Planella Dolors González Joaquim Balanzó José L Rodríguez-Sánchez Sílvia Vidal | 2007 | World Journal of Gastroenterology2007，13，41： | 2 |
| 2 | l -Carnitine: An adequate supplement for a multi-targeted anti-wasting therapy in cancer显示文摘 | Sílvia Busquets Roberto Serpe Míriam Toledo Angélica Betancourt Enrica Marmonti Marcel Orpí Fabrizio Pin Eva Capdevila Clelia Madeddu Francisco J. López-Soriano Giovanni Mantovani Antonio Macciò Josep M. Argilés | 2012 | Clinical Nutrition2012，，6： | 2 |
| 3 | The nearest three virtual space vector PWM: a modulation for the comprehensive neutral-point balancing in the three-level NPC inverter显示文摘 | Busquets Monge S Bordonau J Boroyevich D | 2004 | IEEE Power Electronics Letters2004，2，1： | 1 |
| 4 | Effects of cinnamaldehyde and garlic oil on rumen microbial fermentation in a dual flow continuous culture显示文摘 | BUSQUET M CALSAMIGLIA S FERRET A | 2005 | Journal of Dairy Science2005，88，7： | 1 |
| 5 | Essential oils as modifiers of rumen microbial fermentation显示文摘 | Calsamiglia S Busquet M Cardozo P W | 2007 | Journal of Dairy Science2007，90，6： | 1 |
| 6 | Invited Review:Essential oils as modifiers of rumen microbial fermentation显示文摘 | Calsamiglia S Busquet M Cardozo P W | 2007 | Journal of Dairy Science2007，，90： | 1 |
| 7 | Effect of garlic oil and four of its compounds on rumen microbial fermentation显示文摘 | Busquet Calsamiglia M S Ferret A | 2005 | Journal of Dairy Science2005，，88： | 1 |
| 8 | Plant extracts affect in vitro rnmen microbial fermentation 显示文摘 | Busquet M Calsamiglia S Ferret A | 2006 | Journal of Dairy Science2006，89，： | 1 |
| 9 | Screening for effects of plant extracts and active compounds of plants on dairy cattle rumen microbial fermentation in a continuous culture system显示文摘 | BUSQUET M CALSAMIGLIA S FERRET A | 2005 | Animal Feed Science and Technology2005，124，2： | 1 |
| 10 | Invited review: essential oils as modifiers of tureen microbial fermentation显示文摘 | CALSAMIGLIA S BUSQUET M CARDOZO P W | 2007 | J Dairy Sci2007，90，6： | 1 |
| 11 | Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer model 显示文摘 | BUSQUETS S AMETLLER E FUSTER G | 2007 | Cancer Lett2007，245，12： | 1 |
| 12 | Effect of garlic oil and four of its compounds on lumen microbial fermentation显示文摘 | BUSQUET M CALSAMIGLIA S FERRET A | 2005 | J Dairy Sci2005，88，12： | 1 |
| 13 | Plant extracts affect in vitro rumen microbial fermentation显示文摘 | Busquet M Calsamiglia S Ferret A | 2006 | J Dairy Sci2006，89，： | 1 |
| 14 | Effect of garlic oil and four of its compounds on rumen microbial fermentation显示文摘 | Busquet M Calsamiglia S Ferret A | 2005 | J Dairy Sci2005，88，： | 1 |
| 15 | Effect of garlic oil and four of its compounds on rumen microbial fermentation显示文摘 | BUSQUET M CALSAMIGLIA S FERRET A | 2005 | Journal of Dairy Science2005，88，： | 1 |
| 16 | Curcumin, a natural product present in turmeric, decreases tumor growth but does not behave as an anticachectic compound in a rat model 显示文摘 | Busquets S Carbo N Almendro V | 2001 | Cancer Lett2001，167，1： | 1 |
| 17 | Effect of garlic oil and four of its compounds on rumen microbial fermentation显示文摘 | BUSQUET M CALSAMIGLIA S FERRET A | 2005 | Journal of Dairy Science2005，88，12： | 1 |
| 18 | Plant extracts affect in vitro rumen microbial fermentation显示文摘 | BUSQUET M CALSAMIGLIA S FERRET A | 2006 | Journal of Dairy Science2006，89，2： | 1 |
| 19 | Screening for the effects of natural plant extracts and secondary plant metabolites on rumen microbial fermentation in continuous culture显示文摘 | Busquet M Calsamiglia S Ferret A | 2005 | Anim Feed Sci Technol2005，123，： | 1 |
| 20 | Effects of cinna-maldehyde and garlic oil on rumen microbial fermentation in a dual flow continuous culture 显示文摘 | Busquet M Calsamiglia S Ferret A | 2005 | J Dairy Sci2005，88，： | 1 |
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