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| 1 | Contrast-enhanced ultrasound evaluation of hepatic microvascular changes in liver diseases显示文摘AIM:To assess if software assisted-contrast-enhanced ultrasonography (CEUS) provides reproducible perfusion parameters of hepatic parenchyma in patients affected by chronic liver disease. METHODS:Forty patients with chronic viral liver disease, with (n = 20) or without (n = 20) cirrhosis, and 10 healthy subjects underwent CEUS and video recordings of each examination were then analysed with Esaote's Qontrast software. CEUS dedicated software Qontrast was used to determine peak (the maximum signal intensity), time to peak (TTP), region of blood value (RBV) proportional to the area under the time-intensity curve, mean transit time (MTT) measured in seconds and region of blood flow (RBF). RESULTS:Qontrast-assisted CEUS parameters displayed high inter-observer reproducibility (k coefficients of 0.87 for MTT and 0.90 TTP). When the region of interest included a main hepatic vein, Qontrast-calculated TTP was significantly shorter in cirrhotic patients (vs non-cirrhotics and healthy subjects) (71.0 ± 11.3 s vs 82.4 ± 15.6 s, 86.3 ± 20.3 s, P < 0.05). MTTs in the patients with liver cirrhosis were significantly shorter than those of controls (111.9 ± 22.0 s vs 139.4 ± 39.8 s, P < 0.05), but there was no significant difference between the cirrhotic and non-cirrhotic groups (111.9 ± 22.0 s vs 110.3 ± 14.6 s). Peak enhancement in the patients with liver cirrhosis was also higher than that observed in controls (23.9 ± 5.9 vs 18.9 ± 7.1, P = 0.05). There were no significant intergroup differences in the RBVs and RBFs. CONCLUSION:Qontrast-assisted CEUS revealed reproducible differences in liver perfusion parameters during the development of hepatic fibrogenesis. | Francesco Ridolfi Teresa Abbattista Paolo Busilacchi Eugenio Brunelli | 2012 | World Journal of Gastroenterology2012，18，37： | 10 |
| 2 | Contrast-enhanced ultrasound to evaluate the severity of chronic hepatitis C显示文摘 | F. Ridolfi T. Abbattista F. Marini A. Vedovelli P. Quagliarini P. Busilacchi E. Brunelli | 2007 | Digestive and Liver Disease2007，，10： | 1 |
| 3 | Chitosan, hyaluronan and chondroitin sulfate in tissue engineering for cartilage regeneration: a review 显示文摘 | Muzzarelli RA Greco F Busilacchi A | 2012 | Carbohydr Polym2012，89，3： | 1 |
| 4 | Comparing geometric morphometrics and outline fitting methods to monitor fish shape variability of Diplodus puntazzo (Teleostea: Sparidae)显示文摘 | Loy A Busilacchi S Costa C | 2000 | Aquacultural Engineering2000，21，4： | 1 |
| 5 | Chitosan, hyaluronan and chondroitin sulfate in tissue engineering for cartilage regeneration: A review显示文摘 | MUZZARELLI R A GRECO F BUSILACCHI A | 2012 | Carbohydrate Polymers2012，89，3： | 1 |
| 6 | Chitosan stabi- lizes platelet growth factors and modulates stem cell differentiation toward tissue regeneration显示文摘 | Busilacchi A Gigante A Mattioli-Belmonte M | 2013 | Carbohydr Polym2013，98，1： | 1 |
| 7 | Pancreatic cystadenocarcinoma:diagnostic problems显示文摘 | Busilacchi P Rizzatto G Bazzocchi M | 1982 | Br J Radiol1982，55，656： | 1 |
| 8 | Diagnosis of liver cirrhosis by transit-time analysis at contrast-enhanced ultrasonography显示文摘 | T. Abbattista F. Ridolfi E. Ciabattoni F. Marini E. Bendia E. Brunelli P. Busilacchi | 2008 | La radiologia medica2008，，6： | 1 |
| 9 | Chitosan stabilizes platelet growth factors and modulates stem cell differentiation toward tissue regeneration 显示文摘 | BUSILACCHI A GIGANTE A BELMONTE-MATTIOLI M | 2013 | Carbohydrate Polymers2013，98，1： | 1 |
| 10 | Chitosan, hyaluronan and chondroitin sulfate in tissue engineering for cartilage regeneration: A review显示文摘 | Muzzarelli R A A Greco F Busilacchi A | 2012 | Carbohydrate Polymers2012，89，3： | 1 |
| 11 | Matrix-induced autol- ogous chondrocyte implantation (MACI) in the knee显示文摘 | Enea D Ceeconi S Busilacchi A | 2012 | Knee Surg Sports Traumatol Arthrosc2012，20，5： | 1 |
| 12 | Chi- tosan stabilizes platelet growth factors and modulates stem cell differentiation toward tissue regeneration显示文摘 | Busilacchi A Gigante A Mattioli-Belmonte M | 2013 | Carbohydr Polym2013，98，1： | 1 |
| 13 | Biological augmentation and tissue engineering approaches in meniscus surgery 显示文摘 | Moran C J Busilacchi A Lee CA | 2015 | Arthroscopy2015，31，5： | 1 |
| 14 | Chitosan,hyaluronan and chondroitin sulfate in tissue engineering for cartilage regeneration:a review显示文摘 | Muzzarelli RA Greco F Busilacchi A | 2012 | Carbohydr Polym2012，89，3： | 1 |
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