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| 1 | Comparisons between glucose analogue 2-deoxy-2-(^(18)F)fluoro-D-glucose and ^(18)F-sodium fluoride positron emission tomography/computed tomography in breast cancer patients with bone lesions显示文摘AIM: To compare 2-deoxy-2-(^(18)F)fluoro-D-glucose(^(18)FFDG) and ^(18)F-sodium(^(18)F-NaF) positron emission tomography/computed tomography(PET/CT) accuracy in breast cancer patients with clinically/radiologically suspected or known bone metastases.METHODS: A total of 45 consecutive patients with breast cancer and the presence or clinical/biochemical or radiological suspicion of bone metastatic disease underwent ^(18)F-FDG and ^(18)F-fluoride PET/CT. Imaging results were compared with histopathology when available, or clinical and radiological follow-up of at least 1 year. For each technique we calculated: Sensitivity(Se), specificity(Sp), overall accuracy, positive and negative predictive values, error rate, and Youden's index. Mc Nemar's χ~2 test was used to test the difference in sensitivity and specificity between the two diagnostic methods. All analyses were computed on a patient basis, and then on a lesion basis, with consideration ofthe density of independent lesions on the coregistered CT(sclerotic, lytic, mixed, no-lesions) and the divergent site of disease(skull, spine, ribs, extremities, pelvis). The impact of adding ^(18)F-Na F PET/CT to the work-up of patients was also measured in terms of change in their management due to ^(18)F-Na F PET/CT findings. RESULTS: The two imaging methods of ^(18)F-FDG and ^(18)F-fluoride PET/CT were significantly different at the patient-based analysis: Accuracy was 86.7% and 84.4%, respectively(Mc Nemar's χ~2 = 6.23, df = 1, P = 0.01). Overall, 244 bone lesions were detected in our analysis. The overall accuracy of the two methods was significantly different at lesion-based analysis(Mc Nemar's χ~2 = 93.4, df = 1, P < 0.0001). In the lesion density-based and site-based analysis, ^(18)F-FDG PET/CT provided more accurate results in the detection of CT-negative metastasis(P < 0.002) and vertebral localizations(P < 0.002); ^(18)F-Na F PET/CT was more accurate in detecting sclerotic(P < 0.005) and rib lesions(P < 0.04). ^(18)F-Na F PET/CT led to a change of management in 3 of the 45 patients(6.6%) by revealing findings that were not detected at ^(18)F-FDG PET/CT. CONCLUSION: ^(18)F-FDG PET/CT is a reliable imaging tool in the detection of bone metastasis in most cases, with a diagnostic accuracy that is slightly, but significantly, superior to that of ^(18)F-Na F PET/CT in the general population of breast cancer patients. However, the extremely high sensitivity of ^(18)F-fluoride PET/CT can exploit its diagnostic potential in specific clinical settings(i.e., small CT-evident sclerotic lesions, high clinical suspicious of relapse, and negative ^(18)F-FDG PET and conventional imaging). | Selene Capitanio Francesca Bongioanni Arnoldo Piccardo Claudio Campus Roberta Gonella Lucia Tixi Mehrdad Naseri Michele Pennone Vania Altrinetti Ambra Buschiazzo Irene Bossert Francesco Fiz Andrea Bruno Andrea DeCensi Gianmario Sambuceti Silvia Morbelli | 2016 | World Journal of Radiology2016，8，2： | 3 |
| 2 | Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa显示文摘Autophagy is invoIved in spermatogenesis by regulating germ cell maturation.This catabolic process increases with hyperthermic conditions to prevent the accumulation of damaged organelles.Cryptorchidism is associated with impairment of germ cell maturation revealed by the presence of immature forms of sperm cells in ejaculates.The aim of the present study was to evaluate the status of autophagy in sperm cells from cryptorchid patients.Semen samples of cryptorchid patients and normozoospermic controls were analyzed by immuno cytochemistry and electron microscopy.Autophagy protei ns,autophagy-related protein 9(ATG9)and microtubule-associated protein,lA/lB-light chain 3(LC3)were localized by immunocytochemistry on the acrosome and on the equatorial segment of sperm cells.LC3 was also detected in the midpiece of cryptorchid sperm tail.Autophagy substrate p62 protein was present in the acrosome and in the postequatorial segment of sperm in control samples,but not in the cryptorchid ones.Transmission electron microscopy revealed double-membrane-limited autophagosomes in postequatorial part of spermatozoa head and midpiece in cryptorchid samples.Partly degraded mitochondria were frequently discerned in autophagic vacuoles.In conclusion,autophagy is increased in sperm cells from patients with cryptorchid history comparatively to control.Our work provides insights into the role of autophagy in the maturation and survival of human male gametes in pathological conditions.Thus,regulating autophagy could represent a potential way to improve sperm quality in cryptorchid men. | Marina G Yefimova Antoine Buschiazzo Agnes Burel Marie-Therese Lavault Celine Pimentel Guilhem Jouve Sylvie Jaillard Bernard Jegou Nicolas Bourmeyster Celia Ravel | 2019 | Asian Journal of Andrology2019，21，6： | 2 |
| 3 | Microsatellite tandem repeats are abundant in human promoters and are associated with regulatory elements显示文摘 | Sawaya S Bagshaw A Buschiazzo E | 2013 | PLoS One2013，8，54： | 1 |
| 4 | Wind erosion uantity and uality of an Entic Haplustoll of the semi-arid pampas of Argentina显示文摘 | Daniel E Buschiazzo T Oobeck S | 2007 | Journal of Arid Environments2007，69，6： | 1 |
| 5 | Degradation of the soil surface roughness by rainfall in two loess soils显示文摘 | De Oro L A and Buschiazzo D E | 2011 | Geoderma2011，164，1： | 1 |
| 6 | Wind erosion quantity and quality of an Entic Haplustoll of the semi-arid pampas of Argentina显示文摘 | BUSCHIAZZO Daniel E ZOBECK Ted M ABASCAL Sergio A | 2007 | Journal of Arid Environments2007，，： | 1 |
| 7 | Mechanical control ofshrubs in a semiarid region of Argentina and its effect on soil watercontent and grassland productivity 显示文摘 | Adema E 0 Buschiazzo D E Babinec F J | 2004 | Agricultural Water Anage-ment2004，68，2： | 1 |
| 8 | Combined epidermal growth factor and hyaluronic acid supplementation of in vitro maturation medium and its impact on bovine oocyte proteome and competence显示文摘 | Rios G L Buschiazzo J Mucci N C | 2015 | Theriogenology2015，83，5： | 1 |
| 9 | Comparison of different mass transport calculation methods for wind erosion quantification purposes显示文摘 | Panebianco J E Buschiazzo D E Zobeck T M | 2010 | Earth Surface Processes and Landforms2010，24，： | 1 |
| 10 | Field wind erosion measurements with Big Spring Number Eight (BSNE) and Modified Wilson and Cook (MWAC) samplers显示文摘 | Mendez M J Furlk R Buschiazzo D E | 2011 | Geomor phology2011，129，12： | 1 |
| 11 | A simplified version of Ankylosing Spondylitis Disease Activity Score(ASDAS)in patients with ankylosing spondylitis显示文摘 | Sommerfleck FA Schneeberger EE Buschiazzo EE | 2012 | Clin Rheumatol2012，31，11： | 1 |
| 12 | Cation exchange capacity and mineralogy of loess soils with different amounts of volcanic ashes显示文摘 | Iturri L A Buschiazzo D E | 2014 | Catena2014，121，10： | 1 |
| 13 | Wind erosion uantity and uality of an Entic Haplustoll of the semi-arid pampas of Argentina显示文摘 | Daniel E Buschiazzo T Oobeck S | 2007 | Journal of Arid Environments2007，69，6： | 1 |
| 14 | Wind erosion risk in agricultural soils under different tillage systems in the Semiarid Pampas of Argentina显示文摘 | Mendez M J Buschiazzo D E | 2010 | Soil & Tillage Research2010，106，2： | 1 |
| 15 | Cultivation effects on phosphate forms and sorption inloess-soils of Argentina显示文摘 | Buschiazzo DE Hevia GG Urioste AM Hepper EN | 2000 | Soil Science2000，165，42： | 1 |
| 16 | Soil properties related to potential particulate matter emissions (PM10) of sandy soils显示文摘 | Aimar SB Mendez MJ Funk R Buschiazzo DE | 2012 | Aeolian Research2012，3，4： | 1 |
| 17 | Swapping FAD binding motifs between plastidic and bacterialferredoxin-NADP (H) reductases 显示文摘 | Musumeci MA Botti H Buschiazzo A Buschiazzo A CeccarelliEA | 2011 | Biochemistry2011，50，12： | 1 |
| 18 | Soil dry aggregate stability and wind erodible fraction in a semiarid environment of Argentina显示文摘 | Colazo JC Buschiazzo DE | 2010 | Geoderma2010，159，1： | 1 |
| 19 | Soil properties related to potential particulate matter emissions (PM10) of sandy soils显示文摘 | Silvia B. Aimar Mariano J. Mendez Roger Funk Daniel E. Buschiazzo | 2011 | Aeolian Research2011，，4： | 1 |
| 20 | Wind erosion quantity and quality of an Entic Haplustoll of the semi-arid pampas of Argentina 显示文摘 | Daniel E Buschiazzo Ted M Oobeck Bascal S A | 2007 | Journal of Arid Environments2007，69，1： | 1 |
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