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| 1 | 超声血流向量成像技术评价扩张型心肌病左心室血流状态的变化显示文摘目的 应用超声血流向量成像(VFM)技术探讨心腔内血流的结构变化及其与左室功能之间的关系.方法 选取扩张型心肌病患者26例、正常对照44例为观察对象,利用VFM软件采集左室内血流向量图像,应用VFM分析软件DSA-RS1测量收缩期心尖部-主动脉瓣口速度阶差(△Vs)、心尖部-主动脉瓣口距离(Ds)、半距对应速度(Vs1/2);舒张期二尖瓣口-心尖部速度阶差(△Vd)、二尖瓣口-心尖部距离(Dd)、半距对应速度(Vd1/2).结果 与对照组相比,DCM组收缩期△Vs、Vs1/2与舒张期△Vd、Vd1/2明显降低,收缩期Ds与舒张期Dd明显延长,差异均具有统计学意义(P<0.05).Ds、Dd与舒张末期容积、收缩末期容积、左室内径呈正相关(r>0.4,P<0.01),与收缩功能呈负相关(r>0.3,P<0.01);Vs1/2、Vd1/2与舒张末期容积、收缩末期容积、左室内径呈负相关(r>0.3,P<0.01),与收缩功能呈正相关(r>0.3,P<0.01).结论 扩张型心肌病患者心腔内血流速度明显低于正常人,VFM是一种无创评价扩张型心肌病左室内血流动力学变化的新方法. | 朱美华 邓又斌 黎春雷 毕小军 王玉波 刘娅妮 Mba Mba Cyprien | 2010 | 中华超声影像学杂志2010，，9： | 10 |
| 2 | 多巴酚丁胺负荷超声心动图结合心肌灌注造影早期诊断冠心病的价值显示文摘目的探讨大剂量多巴酚丁胺负荷超声心动图(DSE)结合心肌灌注造影(MCE)技术早期诊断冠心病的价值。方法对临床可疑冠心病的38例患者进行大剂量多巴酚丁胺负荷试验,分别在静息状态和试验终止的即刻实行MCE检查。并在静息状态及各级负荷状态下观察室壁运动(wM)情况;对每次MEC后各心肌节段灌注状态进行评估。大剂量DSE时,以冠状动脉造影为金标准比较WM目测法和心肌灌注状态目测法诊断冠心病的敏感性和特异性。结果DSE时,9例(24%)患者达到峰值负荷水平,22例(58%)达到中级负荷水平。DSE终止时,通过心肌灌注状态目测法及wM目测法诊断有心肌缺血患者的例数分别为24例(89%)及15例(52%)(P〈0.01)。同时,通过上述两组方法评估心肌缺血,并根据相应缺血心肌节段所对应冠脉分支准确判断病变血管的敏感性分别为71%及41%(P〈0.01)。结论大剂量DSE结合心肌灌注造影可以提高检出缺血心肌的敏感性,发现隐匿性心肌缺血,为临床诊断早期冠心病患者提供了无创性新方法。 | 毕小军 邓又斌 Cyprien MBA MBA 刘蓉 朱英 黎春雷 | 2011 | 中华超声影像学杂志2011，20，8： | 6 |
| 3 | Planting position and shade enhance native seedling performance in forest restoration for an endangered malagasy plant显示文摘The critically endangered tree Schizolaena tampoketsana is confined to a few diminished and degraded forest fragments on the Malagasy highlands. This habitat is vulnerable to loss due to frequent fires in the surrounding grassland that threaten to spread into the forest. One of these fragments is the focus a conservation project and here the managers aim to conserve S. tampoketsana by restoring its forest habitat to its former extent as evidenced by remnant woody plants. To inform this activity the survival and early-stage growth of seedlings of four locally native tree species were compared under contrasting conditions of proximity to the remaining forest and shade. After 12 months, seedlings of three species(Baronia taratana, Eugenia pluricymosa, Uapaca densifolia) survived better and experienced improved growth in height in grassland close to the existing forest rather than distant from it, and two survived better with shade rather than unshaded. A number of mechanisms could explain these results including reduced exposure to desiccating sunlight and winds and better soil and greater water availability close to the forest. The seedlings of one species(Nuxia capitata) survived well under all conditions. This study suggests that reforestation in these dry highlands is most feasible adjacent to remnant forest fragments and in microhabitats that minimize water loss, though young plants of some tree species may be capable of surviving in harsher conditions. | Cyprien Miandrimanana J.Leighton Reid Tahiry Rivoharison Chris Birkinshaw | 2019 | Plant Diversity2019，41，2： | 3 |
| 4 | 大剂量多巴酚丁胺负荷试验结合二维应变成像技术早期诊断冠心病的价值显示文摘目的 探讨大剂量多巴酚丁胺负荷试验结合二维应变成像技术早期诊断冠心病的价值.方法 对临床可疑的冠心病患者28例进行大剂量多巴酚丁胺负荷试验,分别在静息状态及各级负荷状态下观察室壁运动情况,测定左室各心肌节段心内膜下心肌的纵向收缩期峰值应变,比较大剂量多巴酚丁胺负荷试验目测法及大剂量多巴酚丁胺负荷试验结合二维应变成像技术诊断缺血心肌的敏感性和特异性;计算正常组、冠心病组缺血节段和非缺血节段的纵向收缩期峰值应变平均值并进行组内及组间比较,利用ROC曲线下面积评价纵向收缩期峰值应变预测缺血心肌的敏感性和特异性.结果 冠心病组多巴酚丁胺剂量为40μg·kg^-1·min^-1时目测法检出室壁运动异常6例(共20个节段),通过计算纵向收缩期峰值应变检出缺血心肌15例(共148节段);冠心病组大多数缺血节段纵向收缩期峰值应变较正常组及非缺血节段相同负荷状态明显减低(P<0.05);大剂量多巴酚丁胺负荷试验目测法和大剂量多巴酚丁胺负荷试验结合二维应变成像技术诊断缺血心肌的敏感性分别为35.3%和88.2%(P<0.01),特异性分别为100%和100%(P>0.05)、准确性分别为60.7%和92.8%(P<0.01).多巴酚丁胺剂量为40μg·kg^-1·min^-1时以纵向收缩期峰值应变绝对值≤14.9%为截断值,预测缺血心肌节段的敏感性和特异性分别为83.3%和91.7%.结论 大剂量多巴酚丁胺负荷试验结合二维应变成像技术可以提高检出缺血心肌的敏感性,定量评价心肌收缩功能的微小改变,发现隐匿性心肌缺血,为临床诊断早期冠心病患者提供了无创性新方法 . | Cyprien MBA MBA 邓又斌 毕小军 王文璇 刘蓉 朱英 | 2011 | 中华超声影像学杂志2011，20，2： | 3 |
| 5 | Association between early viral lower respiratory tract infections and subsequent asthma development显示文摘BACKGROUND The association between hospitalization for human respiratory syncytial virus(HRSV)bronchiolitis in early childhood and subsequent asthma is well established.The long-term prognosis for non-bronchiolitis lower respiratory tract infections(LRTI)caused by viruses different from HRSV and rhinovirus,on the other hand,has received less interest.AIM To investigate the relationship between infant LRTI and later asthma and examine the influence of confounding factors.METHODS The PubMed and Global Index Medicus bibliographic databases were used to search for articles published up to October 2021 for this systematic review.We included cohort studies comparing the incidence of asthma between patients with and without LRTI at≤2 years regardless of the virus responsible.The meta-analysis was performed using the random effects model.Sources of heterogeneity were assessed by stratified analyses.RESULTS This review included 15 articles(18 unique studies)that met the inclusion criteria.LRTIs at≤2 years were associated with an increased risk of subsequent asthma up to 20 years[odds ratio(OR)=5.0,95%CI:3.3-7.5],with doctor-diagnosed asthma(OR=5.3,95%CI:3.3-8.6),current asthma(OR=5.4,95%CI:2.7-10.6),and current medication for asthma(OR=1.2,95%CI:0.7-3.9).Our overall estimates were not affected by publication bias(P=0.671),but there was significant heterogeneity[I 2=58.8%(30.6-75.5)].Compared to studies with hospitalized controls without LRTI,those with ambulatory controls had a significantly higher strength of association between LRTIs and subsequent asthma.The strength of the association between LRTIs and later asthma varied significantly by country and age at the time of the interview.The sensitivity analyses including only studies with similar proportions of confounding factors(gender,age at LRTI development,age at interview,gestational age,birth weight,weight,height,smoking exposure,crowding,family history of atopy,and family history of asthma)between cases and controls did not alter the overall estimates.CONCLUSION Regardless of the causative virus and confounding factors,viral LRTIs in children<2 years are associated with an increased risk of developing a subsequent asthma.Parents and pediatricians should be informed of this risk. | Sebastien Kenmoe Etienne Atenguena Okobalemba Guy Roussel Takuissu Jean Thierry Ebogo-Belobo Martin Gael Oyono Jeannette Nina Magoudjou-Pekam Ginette Irma Kame-Ngasse Jean Bosco Taya-Fokou Chris Andre Mbongue Mikangue Raoul Kenfack-Momo Donatien Serge Mbaga Arnol Bowo-Ngandji Cyprien Kengne-Ndé Seraphine Nkie Esemu Richard Njouom Lucy Ndip | 2022 | World Journal of Critical Care Medicine2022，11，4： | 3 |
| 6 | Combined Nitritation-Anammox : Advances in Understanding Process Stability显示文摘 | JOSS A DERLON N CYPRIEN C | 2011 | Environmental Science & Technology2011，45，22： | 1 |
| 7 | Combined nitritation anammox: Advances in understanding process stability 显示文摘 | Joss A Derlon N Cyprien C | 2011 | Environmental Science and Technology2011，45，22： | 1 |
| 8 | GPU Shape Grammars显示文摘 | Jean‐Eudes Marvie Cyprien Buron Pascal Gautron Patrice Hirtzlin Ga?l Sourimant | 2012 | Computer Graphics Forum (pt)2012，，7： | 1 |
| 9 | Global prevalence of hepatitis B virus serological markers among healthcare workers:A systematic review and meta-analysis显示文摘BACKGROUND The hepatitis B virus(HBV)infection is a global public health concern that affects about 2 billion people and causes 1 million people deaths yearly.HBV is a bloodborne disease and healthcare workers(HCWs)are a high-risk group because of occupational hazard to patients’blood.Different regions of the world show a highly variable proportion of HCWs infected and/or immunized against HBV.Global data on serologic markers of HBV infection and immunization in HCWs are very important to improve strategies for HBV control.AIM To determine the worldwide prevalence of HBV serological markers among HCWs.METHODS In this systematic review and meta–analyses,we searched PubMed and Excerpta Medica Database(Embase)to identify studies published between 1970 and 2019 on the prevalence of HBV serological markers in HCWs worldwide.We also manually searched for references of relevant articles.Four independent investigators selected studies and included those on the prevalence of each of the HBV serological markers including hepatitis B surface antigen(HBsAg),hepatitis e antigen(HBeAg),immunoglobulin M anti-HBc,and anti-HBs.Methodological quality of eligible studies was assessed and random-effect model meta-analysis resulted in the pooled prevalence of HBV serological markers HBV infection in HCWs.Heterogeneity(I²)was assessed using theχ²test on Cochran’s Q statistic and H parameters.Heterogeneity’sources were explored through subgroup and metaregression analyses.This study is registered with PROSPERO,number CRD42019137144.RESULTS We reviewed 14059 references,out of which 227 studies corresponding to 448 prevalence data among HCWs(224936 HCWs recruited from 1964 to 2019 in 71 countries)were included in this meta-analysis.The pooled seroprevalences of current HBsAg,current HBeAg,and acute HBV infection among HCWs were 2.3%[95% confidence interval(CI):1.9-2.7],0.2%(95%CI:0.0-1.7),and 5.3%(95%CI:1.4-11.2),respectively.The pooled seroprevalences of total immunity against HBV and immunity acquired by natural HBV infection in HCWs were 56.6%(95%CI:48.7-63.4)and 9.2%(95%CI:6.8-11.8),respectively.HBV infection was more prevalent in HCWs in low-income countries,particularly in Africa.The highest immunization rates against HBV in HCWs were recorded in urban areas and in high-income countries including Europe,the Eastern Mediterranean and the Western Pacific.CONCLUSION New strategies are needed to improve awareness,training,screening,vaccination,post-exposure management and treatment of HBV infection in HCWs,and particularly in low-income regions. | Gadji Mahamat Sebastien Kenmoe Etheline W Akazong Jean Thierry Ebogo-Belobo Donatien Serge Mbaga Arnol Bowo-Ngandji Joseph Rodrigue Foe-Essomba Marie Amougou-Atsama Chavely Gwladys Monamele Chris Andre Mbongue Mikangue Ginette Irma Kame-Ngasse Jeannette Nina Magoudjou-Pekam Cromwel Zemnou-Tepap Dowbiss Meta-Djomsi Martin Maidadi-Foudi Sabine Aimee Touangnou-Chamda Audrey Gaelle Daha-Tchoffo Abdel Aziz Selly-Ngaloumo Rachel Audrey Nayang-Mundo Jacqueline Felicite Yengue Jean Bosco Taya-Fokou Lorraine K M Fokou Raoul Kenfack-Momo Dimitri Tchami Ngongang Efietngab Atembeh Noura Herve Raoul Tazokong Cynthia Paola Demeni Emoh Cyprien Kengne-Nde Jean Joel Bigna Onana Boyomo Richard Njouom | 2021 | World Journal of Hepatology2021，13，9： | 1 |
| 10 | Suicidal behavior is associated with reduced corpus callosum area显示文摘 | Cyprien F Courtet P Malafosse A | 2011 | Biol Psychia- try2011，70，4： | 1 |
| 11 | 不同剂量多巴酚丁胺对正常心肌纵向收缩期峰值应变的影响显示文摘目的探讨不同剂量多巴酚丁胺对正常人纵向收缩期峰值应变的影响。方法对11例冠状动脉造影正常或狭窄<50%的正常人,进行大剂量多巴酚丁胺负荷试验。分别在静息状态、5、10、20、30和40μg/(kg·min)测定左室各心肌节段心内膜下心肌的纵向收缩期峰值应变并进行统计学分析。结果在静息状态下及各级负荷状态下左室心肌纵向收缩期峰值应变从基底段至心尖段逐渐增加。在心尖段,后间隔和下壁的纵向收缩期峰值应变值大于其他节段;在中间段,下壁和前间隔的纵向收缩期峰值应变值大于其他节段;在基底段,前壁和后壁的纵向收缩期峰值应变值大于其他节段。多巴酚丁胺负荷试验中,心肌各节段的纵向收缩期峰值应变值随着多巴酚丁胺剂量的增加而增加,大多数节段在多巴酚丁胺剂量20μg/(kg·min)时达到峰值,个别节段多巴酚丁胺剂量30μg/(kg·min)时达到峰值,峰值纵向收缩期峰值应变与同组静息状态比较,差异有统计学意义(P<0.05);多巴酚丁胺剂量40μg/(kg·min)时,大多数节段纵向收缩期峰值应变与静息状态比较轻度下降,个别节段稍增高,差异无统计学意义(P>0.05)。结论正常心肌节段的纵向收缩期峰值应变随着多巴酚丁胺负荷剂量的增加而增加,但当剂量达到40μg/(kg·min)时,开始恢复到静息水平或有所降低。 | 毕小军 Cyprien MBA MBA 邓又斌 | 2012 | 中国超声医学杂志2012，28，2： | 1 |
| 12 | Combined nitritation-anammox:Advances in understanding process stability显示文摘 | Joss A Derlon N Cyprien C | 2011 | Environmental Science & Technology2011，45，22： | 1 |
| 13 | Humeral retrotorsion and glenohumeral relationship in the normal shoulder and in recurrent anterior dislocation (scapulometry)显示文摘 | Cyprien JM Vasey HM Burdet A | 1983 | Clin Orthop Relat Res1983，175，： | 1 |
| 14 | Combined nitritation- anammox: Advances in understanding process stability显示文摘 | Joss A Derlon N Cyprien C | 2011 | Environmental Science and Technology2011，45，22： | 1 |
| 15 | Combined nitritation- anammox: Advances in understanding process stability 显示文摘 | Joss A Derlon N Cyprien C | 2011 | Environ Sci Technol2011，45，22： | 1 |
| 16 | 心肌灌注造影在多巴酚丁胺负荷前后早期诊断冠心病的临床研究显示文摘目的探讨心肌灌注造影(MCE)技术在大剂量多巴酚丁胺负荷前后早期诊断冠心病的价值。方法对临床疑为冠心病患者38例,进行大剂量多巴酚丁胺负荷超声心动图试验,分别在静息状态和多巴酚丁胺负荷超声心动图试验终止时即刻行MCE检查。以冠状动脉造影为金标准将大剂量多巴酚丁胺负荷超声心动图前后心肌灌注状态目测法对冠心病的检出率进行比较。结果多巴酚丁胺负荷超声心动图检查的38例患者中,9例(24%,9/38)达到峰值负荷水平,22例(58%,22/38)达到中级负荷水平。其中通过冠状动脉造影诊断的27例冠心病患者在多巴酚丁胺负荷前后,通过心肌灌注状态目测法诊断心肌缺血患者的例数分别为10例(37%,10/27)及24例(89%,24/27,χ2=15.565,P<0.01)。结论大剂量多巴酚丁胺负荷超声心动图结合MCE可提高缺血心肌的检出率,发现隐匿性心肌缺血,为临床无创性诊断早期冠心病患者提供新方法。 | 毕小军 邓又斌 Cyprien MBA MBA 刘蓉 朱英 黎春雷 | 2012 | 中华医学超声杂志(电子版)2012，9，6： | 1 |
| 17 | Control of erythropoiesis after high altitude acclimatization显示文摘 | Gustave Savourey Jean-Claude Launay Yves Besnard Angélique Guinet Cyprien Bourrilhon Damien Cabane Serge Martin Jean-Pierre Caravel Jean-Marc Péquignot Jean-Marie Cottet-Emard | 2004 | European Journal of Applied Physiology (-)2004，，1： | 1 |
| 18 | Correlation and path coefficient analy-sis of rice cultivars data显示文摘 | CYPRIEN M KUMAR V | 2011 | Journal of Reliability and StatisticalStudies2011，4，2： | 1 |
| 19 | SNAREs and associated regulators in the control of exocytosis in the RBL-2H3mast cell line显示文摘 | Blank U Cyprien B Martin-Verdeaux S | 2002 | Mol Immunol2002，38，1618： | 1 |
| 20 | Global prevalence of occult hepatitis C virus: A systematic review and meta-analysis显示文摘BACKGROUND Occult hepatitis C infection(OCI)is characterized by the presence of hepatitis C virus(HCV)RNA in the liver,peripheral blood mononuclear cells(PBMC)and/or ultracentrifuged serum in the absence of detectable HCV-RNA in serum.OCI has been described in several categories of populations including hemodialysis patients,patients with a sustained virological response,immunocompromised individuals,patients with abnormal hepatic function,and apparently healthy subjects.AIM To highlight the global prevalence of OCI.METHODS We performed a systematic and comprehensive literature search in the following 4 electronic databases PubMed,EMBASE,Global Index Medicus,and Web of Science up to 6th May 2021 to retrieve relevant studies published in the field.Included studies were unrestricted population categories with known RNA status in serum,PBMC,liver tissue and/or ultracentrifuged serum.Data were extracted independently by each author and the Hoy et al tool was used to assess the quality of the included studies.We used the random-effect meta-analysis model to estimate the proportions of OCI and their 95%confidence intervals(95%CI).The Cochran's Q-test and the I2 test statistics were used to assess heterogeneity between studies.Funnel plot and Egger test were used to examine publication bias.R software version 4.1.0 was used for all analyses.RESULTS The electronic search resulted in 3950 articles.We obtained 102 prevalence data from 85 included studies.The pooled prevalence of seronegative OCI was estimated to be 9.61%(95%CI:6.84-12.73)with substantial heterogeneity[I^(2)=94.7%(95%CI:93.8%-95.4%),P<0.0001].Seropositive OCI prevalence was estimated to be 13.39%(95%CI:7.85-19.99)with substantial heterogeneity[I^(2)=93.0%(90.8%-94.7%)].Higher seronegative OCI prevalence was found in Southern Europe and Northern Africa,and in patients with abnormal liver function,hematological disorders,and kidney diseases.Higher seropositive OCI prevalence was found in Southern Europe,Northern America,and Northern Africa.CONCLUSION In conclusion,in the present study,it appears that the burden of OCI is high and variable across the different regions and population categories.Further studies on OCI are needed to assess the transmissibility,clinical significance,long-term outcome,and need for treatment. | Donatien Serge Mbaga Sebastien Kenmoe Jacky Njiki Bikoï Guy Roussel Takuissu Marie Amougou-Atsama Etienne Atenguena Okobalemba Jean Thierry Ebogo-Belobo Arnol Bowo-Ngandji Martin Gael Oyono Jeannette Nina Magoudjou-Pekam Ginette Irma Kame-Ngasse Alex Durand Nka Alfloditte Flore Feudjio Cromwel Zemnou-Tepap Elie Adamou Velhima Juliette Laure Ndzie Ondigui Rachel Audrey Nayang-Mundo Sabine Aimee Touangnou-Chamda Yrene Kamtchueng Takeu Jean Bosco Taya-Fokou Chris Andre Mbongue Mikangue Raoul Kenfack-Momo Cyprien Kengne-Ndé Carole Stephanie Sake Seraphine Nkie Esemu Richard Njouom Lucy Ndip Sara Honorine Riwom Essama | 2022 | World Journal of Methodology2022，12，3： | 0 |
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