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| 1 | Incretin based therapies:A novel treatment approach for non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease is considered a hepatic manifestation of metabolic syndrome(MS).The current treatment of non-alcoholic fatty liver disease(NAFLD)principally includes amelioration of MS components by lifestyle modifications but the lack of success in their implementation and sustainment arises the need for effective pharmacological agent in fatty liver treatment.Incretins are gut derived hormones secreted into the circulation in response to nutrient ingestion that enhances glucose-stimulated insulin secretion.Glucagon-like peptide-1(GLP-1)is the most important incretin.Its receptor agonist and inhibitors of dipeptidyl peptidase-4(DPP-4)are used in treatment of type2 diabetes mellitus.DPP-4 serum activity and hepatic expression are shown to be elevated in several hepatic diseases.There are several experimental and clinical trials exploring the efficacy of incretin based therapies in NAFLD treatment.They suggest that GLP-1 analogues might have beneficial effect on hepatic steatosis acting as insulin sensitizers and directly by stimulating GLP-1 receptors expressed on hepatocytes.The use of DPP-4 inhibitors also results in hepatic fat reduction but the mechanism of action remains unclear.There is growing evidence that incretin based therapies have beneficial effects on hepatocytes,however further study analysis are needed to assess the long term effect of incretin based therapies on NAFLD. | Kristina Blaslov Tomislav Bulum Karin Zibar Lea Duvnjak | 2014 | World Journal of Gastroenterology2014，20，23： | 10 |
| 2 | Relationship of vascular complications and exenatide therapy failure in type 2 diabetic patients显示文摘 | Blaslov K Zibar K Bulum T | 2013 | Acta Clin Croat2013，52，3： | 1 |
| 3 | Circulating dipeptidyl peptidase-4 activity is associated with diabetic retinopathy in type 1 diabetic patients 显示文摘 | BLASLOV K BULUM T DUVNJAK L | 2015 | Eur J Ophthalmol2015，25，4： | 1 |
| 4 | The impact of successful manual thrombus aspiration on in-stent restenosis after primary PCI: angiographic and clinical follow-up显示文摘 | Jo?ko Bulum Aleksander Ernst Maja Strozzi | 2012 | Coronary Artery Disease2012，，7： | 1 |
| 5 | The impact of successful manual thrombus aspiration on in-stent restenosis after primary PCI: angiographic and clinical follow-up 显示文摘 | Bulum J Ernst A Strozzi M | 2012 | Coron Artery Dis2012，23，7： | 1 |
| 6 | Safety and efficacy of dual antiplatelet therapy after percutaneous coronary interventions in patients with end-stage liver disease显示文摘The prevalence of coronary artery disease(CAD)increases in patients with endstage liver disease,with part of them receiving the percutaneous coronary intervention(PCI)as a treatment option.Dual antiplatelet therapy(DAPT),a standard of care after PCI,could result in catastrophic consequences in this population.Before PCI and the start of DAPT,it is recommended to assess patient bleeding risk.Based on novel findings,liver cirrhosis does not necessarily lead to a significant increase in bleeding complications.Furthermore,conventional methods,such as the international normalized ratio,might not be appropriate in assessing individual bleeding risk.The highest bleeding risk among cirrhotic patients has a subgroup with severe thrombocytopenia(<50×10^(9)/L)and elevated portal pressure.Therefore,every effort should be made to maintain thrombocyte count above>50×10^(9)/L and prevent variceal bleeding.There is no solid evidence for DAPT in patients with cirrhosis.However,randomized trials investigating short(one month)DAPT duration after PCI with new drug-eluting stents(DES)in a high bleeding risk patient population can be implemented in patients with cirrhosis.Based on retrospective studies(with older stents and protocols),PCI and DAPT appear to be safe but with a higher risk of bleeding complications with longer DAPT usage.Finally,novel methods in assessing CAD severity should be performed to avoid unnecessary PCI and potential risks associated with DAPT.When indicated,PCI should be performed over radial artery using contemporary DES.Complementary medical therapy,such as proton pump inhibitors and beta-blockers,should be prescribed for lower bleeding risk patients.Novel approaches,such as thromboelastography and“preventive”upper endoscopies in PCI circumstances,warn clinical confirmation. | Zvonimir Ostojic Ana Ostojic Josko Bulum Anna Mrzljak | 2021 | World Journal of Cardiology2021，13，11： | 1 |
| 7 | Pathophysiological factors in the development of diabetic nephropathy--new insights 显示文摘 | Blaslov K Bulum T Duvnjak L | 2014 | Acta Med Croatiea2014，68，2： | 1 |
| 8 | High frequency of kidney and urinary tract anomalies in asymptomatic first-degree relatives of patients with CAKUT显示文摘 | Bulum B Ozcakar ZB Ustuner E | 2013 | Pediatr Nephrol2013，28，11： | 1 |
| 9 | Pathophysiological fac- tors in the development of diabetic nephropathy-new insights显示文摘 | BLASLOV K BULUM T DUVNJAK L | 2014 | Acta Med Croatica2014，68，2： | 1 |
| 10 | The metabolic syndrome isassociated with high-normal urinary albumin excretion and retinop-athy in normoalbuminuric type 1 diabetic patients 显示文摘 | Duvnjak L Koki V Bulum T | 2012 | CollAntropol2012，36，4： | 1 |
| 11 | Drug-eluting balloons in patients with non-ST elevation acute coronary syndrome显示文摘 | Kristina Maric Besic Maja Strozzi Eduard Margetic Josko Bulum Branko Kolaric | 2014 | Journal of Cardiology2014，，： | 1 |
| 12 | The role of endothelial dysfunction driven by adipocitokines in the development and progression of microvascular complications in patients with type 1 and type 2 diabetes显示文摘 | Blaslov K Bulum T Duvnjak L | 2015 | Med Hypotheses2015，84，6： | 1 |
| 13 | Pathophysiological factors in the development of diabetic nephropathy-new insights 显示文摘 | Blaslov K Bulum T Duvnjak L | 2014 | Acta Med Croatica2014，68，2： | 1 |
| 14 | Circadian rhythm of blood pressure restoration and nephrotic proteinuria alleviation in a patient with chronic kidney disease after renal sympathetic denervation显示文摘 | Prkacin I Coric-Vlartinovic V Bulum T | 2015 | Acta Clin Croat2015，54，4： | 1 |
| 15 | Pathophysiological factors in the development of diabetic nephropathy--new insights显示文摘 | Blaslov K Bulum T Duvnjak L | 2014 | Acta Med Croatica2014，68，2： | 1 |
| 16 | Endometriosis显示文摘 | Bulum SE | 2009 | N Engl J Med2009，360，3： | 1 |
| 17 | Pathophysiological factors in the development of diabetic nephropathy-new insights 显示文摘 | Blaslov K Bulum T Duvnjak L | 2014 | Acta Med Croatica2014，68，2： | 1 |
| 18 | Effect of exenatide therapy on hepatic fat quantity and hepatic biomarkers in type 2 diabetic patients显示文摘 | Kristina Blaslov Karin Zibar Tomislav Bulum Lea Duvnjak | 2013 | Clinics and Research in Hepatology and Gastroenterology2013，，： | 1 |
| 19 | Relationship between nonalcoholic fatty liver disease markers and renal function in patients with type 1 diabetes显示文摘 | Bulum T Duvnjak L | 2011 | Acta Med Croatica2011，65，3： | 1 |
| 20 | The impact of successful manual thrombus aspiration on in-stent restenosis after primary PCI:angiographic and clinical follow-up显示文摘 | Bulum J Ernst A Strozzi M | 2012 | Coron Artery Dis2012，23，7： | 1 |
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