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| 1 | Resistin mediates the hepatic stellate cell phenotype显示文摘AIM: To describe the role of resistin in liver fibrosis. METHODS: For the in vivo animal study, Sprague Dawley rats were subjected to bile duct ligation (BDL) for 4 wk. Rat liver, adipose tissue (epididymal fat) and serum were analyzed for resistin expression. For the in vitro experiment, rat primary hepatic stellate cells (HSCs) and Kupffer cells (KCs) were used. HSCs were exposed to recombinant resistin, and collagenⅠ, transforming growth factor β1, α smooth muscle actin, tissue inhibitor of metalloproteinase 1 and connective tissue growth factor expression were analyzed. Resistin gene and protein expression was quantified as was the expression of pro-inflammatory cytokines including tumor necrosis factor α (TNFα), interleukin (IL)-1, IL-6, IL-8 and monocyte chemotactic protein-1 (MCP-1). The effects of resistin on HSC proliferation, migration and apoptosis were determined. The effects of resistin on KCs were also investigated. RESULTS: Following BDL, rat epididymal fat and serum rather than liver showed higher resistin expression compared to control rats. In liver, resistin was expressed in quiescent HSCs and KCs. Resistin treatment resulted in enhancement of TNFα , IL-6 , IL-8 and MCP-1 gene expression and increased IL-6 and MCP-1 protein in HSCs. Resistin activated HSC phospho-MAPK/p38, and p38 inhibition diminished IL-6 and MCP-1 expression. Furthermore, resistin facilitated HSC proliferation and migration, but decreased apoptosis which was via an IL-6 and MCP-1 mechanism. Finally, resistin-induced transforming growth factor β1 from KCs enhanced HSC collagenⅠexpression. CONCLUSION: Resistin directly and indirectly modulates HSC behavior towards a more pro-fibrogenic phenotype. | Zhi-Xia Dong Lin Su Joanne Brymora Claire Bird Qing Xie Jacob George Jian-Hua Wang | 2013 | World Journal of Gastroenterology2013，19，28： | 4 |
| 2 | Roles of adipokines in liver injury and fibrosis 显示文摘 | Wang J Brymora J George J | 2008 | Expert Rev Gastroent erol Hepatol2008，2，1： | 1 |
| 3 | Low-fructose diet lowers blood pressure and inflammation in patients with chronic kidney disease显示文摘 | Brymora A Flisinski M Johnson R J | 2012 | Nephrol Dial Transplant2012，7，2： | 1 |
| 4 | Kupffer cells mediate leptin- induced liver fibrosis显示文摘 | Wang J Leclercq I Brymora JM | 2009 | Gastroenterology2009，137，2： | 1 |
| 5 | Kupffer cells mediate leptin - induced liver fibrosis 显示文摘 | Wang J Leclercq I Brymora JM | 2009 | Gastroenterology2009，137，2： | 1 |
| 6 | Kupffer cells mediate leptin-induced liver fibrosis显示文摘 | Wang J Leclercq I Brymora JM | | 0，，02： | 1 |
| 7 | Kupffer cells mediate leptin- induced liver fibrosis 显示文摘 | Wang J Leclercq I Brymora JM | 2009 | Gastroenterology2009，137，2： | 1 |
| 8 | Kupffer cells mediate leptininduced liver fibrosis 显示文摘 | Wang J Leclercq I Brymora JM | 2009 | Gastroenterology2009，137，2： | 1 |
| 9 | The small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein 显示文摘 | Fu D van Dam E M Brymora A | 2007 | Biochim Biophys Acta2007，1773，7： | 1 |
| 10 | Roles of adipokines in liver injury and fibrosis显示文摘 | Wang J Brymora J George J | 2008 | Expert Rev Gastroenterol Hepatol2008，2，1： | 1 |
| 11 | Kupffer cells mediate leptin-induced liver fibrosis显示文摘 | Wang J Leclercq I Brymora JM | 2009 | Gastroenterology2009，137，2： | 1 |
| 12 | The small GTPases Rab5 and RalA regulate intracellular traffic of P-glyeoprotein显示文摘 | Fu D Van Dam EM Brymora A | 2007 | Biochim Biophys Acta2007，1773，7： | 1 |
| 13 | Influence of different stages of experimental chronic kidney disease on rats locomotor and postural skeletal muscles microcirculation显示文摘 | Flisinski M Brymora A Elminowska-Wenda G | | 0，，： | 1 |
| 14 | Roles of adipokines in liver injuryand fibrosis显示文摘 | Wang J Brymora J George J | 2008 | Expert Rev Gastroenterol Hepatol2008，2，： | 1 |
| 15 | Roles of adipokines in liver injury and fibrosis 显示文摘 | Wang J Brymora J George J | 2008 | Expert Rev Castroenteml Hepatol2008，21，： | 1 |
| 16 | Kupffer cells mediate leptin-induced liver fibrosis显示文摘 | Wang J Leclercq I Brymora JM | 2009 | Gastroenterology2009，137，2： | 1 |
| 17 | Kupffer Cells Mediate Leptin-Induced Liver Fibrosis显示文摘 | Jianhua Wang Isabelle Leclercq Joanne M. Brymora Ning Xu Mehdi Ramezani–Moghadam Roslyn M. London David Brigstock Jacob George | 2009 | Gastroenterology2009，，2： | 1 |
| 18 | Kupffer cells mediate leptininduced liver fibrosis显示文摘 | Wang J Leclercq I Brymora JM | 2009 | Gastroenterology2009，137，2： | 1 |
| 19 | Low-fructose diet lowers blood pressure and inflammation in patients with chronic kidney disease显示文摘 | Brymora A Flisinski M Johnson RJ | 2011 | Nephrol Dial Transplant2011，49，9： | 1 |
| 20 | Kupffer cells me-diate leptin-induced liver fibrosis显示文摘 | Wang J Leclercq I Brymora JM | 2009 | Gastroenterol2009，137，： | 1 |
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