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| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 2 | Transcriptional profiling reveals novel interactions between wounding, pathogen, abiotic stress, and hormanal responses in Arabidopsis 显示文摘 | Cheong Y H Chang H S Gupta R | 2002 | Plant Physio12002，129，2： | 1 |
| 3 | Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation 显示文摘 | CHEONG J H YI M LIN Y | 1995 | EMBOJ1995，14，1： | 1 |
| 4 | Asherman syndrome-onecentury later 显示文摘 | Yu D Wong YM Cheong Y | 2008 | Fertil Steril2008，89，4： | 1 |
| 5 | Oviductal microsomal epoxide hydrolase(EPHX1) reduces reactive oxygen species (ROS)level and enhances preimplantation mouse embryo development 显示文摘 | CHEONG A W Y LEE Y L LIU W M | 2009 | Biol Reprod2009，81，： | 1 |
| 6 | Diet-induced maternalobesity alters ovarian morphology and gene expression in the adultmouse offspring显示文摘 | Cheong Y Sadek K H Bruce K D | 2014 | Fertil Steril2014，102，3： | 1 |
| 7 | Molecular and functional characterization of a cyclophilin with antifungal activity from Chinese cabbage 显示文摘 | LEE J R PARK S C KIM J Y LEE S S PARK Y CHEONG G W HAHM K S LEE S Y | 2007 | Biochem Biophys Res Commun2007，353，3： | 1 |
| 8 | Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X trans- activation显示文摘 | Cheong JH Yi M Lin Y | 2005 | EMBOJ2005，14，1： | 1 |
| 9 | Effect of calcium powder addition on the quality characteristics of Kimchi 显示文摘 | Park W P Park K D Cheong Y J | 2002 | Journal of Korean Society of Food Science and Nutrition2002，31，： | 1 |
| 10 | Evaluation of design parameters of osseointegrated dental implants using finite element analysis 显示文摘 | Chun H J Cheong S Y Han J H | 2002 | J Oral Rehabil2002，29，6： | 1 |
| 11 | Analysis of the circumferential guided wave for axial crack detection in a feeder pipe显示文摘 | Cheong Y M Lee D H Kem S S | 2004 | Advances in Noddestructive Evaluation2004，，： | 1 |
| 12 | Characteriza- tion of two fungal - elicitor induced rice cDNAs encoding functional homologues of the rab - specific GDP - dissoci- ation inhibitor显示文摘 | Kim W Y Kim C Y Cheong N E | 1999 | Planta1999，210，1： | 1 |
| 13 | In-house microcomputer software package for management of histopathology reports显示文摘 | Y C Lim S K Cheong | 1992 | The Malaysian journal of pathology1992，14，1： | 1 |
| 14 | Isolation and identification of indigenous quorum quenching bacteria,pseudomonas sp 1A1,for biofouling control in MBR显示文摘 | Cheong W S Lee C H Moon Y H | 2013 | Industrial Engineering Chemistry Research2013，52，10： | 1 |
| 15 | Effect of impact angle and velocity on the fragment size distribution of glass spheres显示文摘 | Cheong Y S Salman A D Hounslow M J | 2003 | Powder Technology2003，138，： | 1 |
| 16 | Congenital nephro- genic diabetes insipidus with a novel mutation in the aqua- porin 2 gene显示文摘 | Park Y J Baik H W Cheong H I | 2014 | Biomed Rep2014，02，04： | 1 |
| 17 | Channel-carrier,rnobility parameters for 4H SiC MOSFETs显示文摘 | LINEWlH H DIMITRIJEV S CHEONG K Y | 2003 | Microelec Reliab2003，43，3： | 1 |
| 18 | Negative thermal ex- pansion coefficient of graphene measured by Raman spectros- copy显示文摘 | YOON D SON Y W CHEONG H | 2011 | NanoLetters2011，11，8： | 1 |
| 19 | Support vector machines with binary tree architecture for muhiclass classification 显示文摘 | Cheong S Oh S H Lee S Y | 2004 | Neural Information Pro- cessing-letters and reviews2004，2，3： | 1 |
| 20 | The coefficient of restitution of different representative types of granules 显示文摘 | Mangwandi C Cheong Y S Adams M J Hounslow M J Salman A D | 2007 | Chemical Engineering Science2007，62，12： | 1 |
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