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| 1 | Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatoceiluiar carcinoma显示文摘AIM: To explore the potential prognostic role of preoperative tumor grade and blood AFP mRNA in a cohort of patients with hepatocellular carcinoma (HCC)eligible for radical therapies according to a well-defined treatment algorithm not including nodule size and number as absolute selection criteria.METHODS: Fifty patients with a diagnosis of HCC were prospectively enrolled in the study. Inclusion criteria were: (1) histological assessment of tumor grade by means of percutaneous biopsies; (2) determination of AFP mRNA status in the blood; (3) patient's eligibility for radical therapies.RESULTS: At preoperative evaluation, 54% of the study group had a well-differentiated HCC, 42% had AFP mRNA in the blood, 40% had a tumor larger than 5 cm and 56% had more than one nodule. Surgery (resection or liver transplantation) was performed in 29 patients,while 21 had percutaneous ablation procedures. After a median follow-up of 28 mo, 12-, 24-, and 36-mo survival rates were 78%, 58%, and 51%, respectively. Surgical therapy, performance status and three tumor-related variables (AFP mRNA, HCC grade and gross vascular invasion) resulted as significant survival predictors at univariate analysis. Nodule size and number did not perform as significant prognosticators. Multivariate study selected only surgical therapy and a biologically early HCC profile (AFP mRNA negative and well-differentiated tumor without gross vascular invasion) as independent survival variables.CONCLUSION: The preoperative determination of tumor grade and blood AFP mRNA status may potentially refine the prognostic evaluation of HCC patients and improve the selection process for radical therapies. | Umberto Cillo Alessandro Vitale Filippo Navaglia Daniela Basso Umberto Montin Marco Bassanello Francesco D'Amico Francesco Antonio Ciarleglio Alberto Brolese Giacomo Zanus Vito De Pascale Mario Plebani Davide Francesco D'Amico | 2005 | World Journal of Gastroenterology2005，11，44： | 12 |
| 2 | Laparoscopic treatment of simple hepatic cysts and polycystic liver disease显示文摘 | P. Fiamingo U. Tedeschi M. Veroux U. Cillo A. Brolese A. Da Rold C. Madia G. Zanus D.F. D'Amico | 2003 | Surgical Endoscopy2003，，4： | 2 |
| 3 | Prospective validation of the Barcelona Clinic Liver Cancer staging system显示文摘 | Umberto Cillo Alessandro Vitale Francesco Grigoletto Fabio Farinati Alberto Brolese Giacomo Zanus Daniele Neri Patrizia Boccagni Nela Srsen Francesco D’Amico Francesco Antonio Ciarleglio Alessio Bridda Davide Francesco D’Amico | 2006 | Journal of Hepatology2006，，4： | 2 |
| 4 | Prognostic impact of model for end-stage liver disease score in patients undergoing liver transplantation with suboptimal livers显示文摘 | Vitale A DAmico F Brolese A et at | 2007 | Transplant Proc2007，39，6： | 1 |
| 5 | Laparoscopic treatment of simple hepatic cysts and polycystic liver disease显示文摘 | P. Fiamingo U. Tedeschi M. Veroux U. Cillo A. Brolese A. Da Rold C. Madia G. Zanus D.F. D’Amico | 2003 | Surgical Endoscopy2003，，4： | 1 |
| 6 | A simple, sensitive and widely applicable EUSA for S100B: methodological features of the measurement of this glial protein 显示文摘 | Leite MC Galland F Brolese G | 2008 | Neurosci Methods2008，169，1： | 1 |
| 7 | Endoscopic treatment of bile duct complications after orthotopic liver transplantation 显示文摘 | Polese L Cillo U Brolese A | 2007 | Transplant Proc2007，39，6： | 1 |
| 8 | Response to Therapy as a Criterion for Awarding Priority to Patients With Hepatocellular Carcinoma Awaiting Liver Transplantation显示文摘 | Alessandro Vitale Francesco D’Amico Anna Chiara Frigo Francesco Grigoletto Alberto Brolese Giacomo Zanus Daniele Neri Amedeo Carraro Francesco Enrico D’Amico Patrizia Burra Francesco Russo Paolo Angeli Umberto Cillo | 2010 | Annals of Surgical Oncology2010，，9： | 1 |
| 9 | The survival benefit of liver transplantation in hepatocellular carcinoma patients显示文摘 | Umberto Cillo Alessandro Vitale Michael L. Volk Anna Chiara Frigo Francesco Grigoletto Alberto Brolese Giacomo Zanus Francesco D’Amico Fabio Farinati Patrizia Burra Francesco Russo Paolo Angeli Davide F. D’Amico | 2010 | Digestive and Liver Disease2010，，9： | 1 |
| 10 | Alcohol Abuse and De Novo Tumors in Liver Transplantation显示文摘 | G. Zanus A. Carraro A. Vitale E. Gringeri F. D’Amico M. Valmasoni F.E. D’Amico A. Brolese P. Boccagni D. Neri N. Srsen P. Burra P. Feltracco P. Bonsignore M. Scopelliti U. Cillo | 2009 | Transplantation Proceedings2009，，4： | 1 |
| 11 | Endoscopic treatment of bile duct complications after orthotopic liver transplantation显示文摘 | Polese L Cillo U Brolese A | 2007 | Transplant Proc2007，39，6： | 1 |
| 12 | Ammonia- induced alteration in S100B secretion in astrocytes is not reverted by creatine addition 显示文摘 | LEITE M C BROLESE G DE A L | 2006 | Brain Res Bull2006，70，2： | 1 |
| 13 | Endoscopic treatment of bile duct complications after orthotopic liver transplantation显示文摘 | Polese L Cillo U Brolese A | 2007 | Transplant Proc2007，39，6： | 1 |
| 14 | The survival benefit of liver transplantation in hepatocellular carcinoma patients显示文摘 | Umberto Cillo Alessandro Vitale Michael L. Volk Anna Chiara Frigo Francesco Grigoletto Alberto Brolese Giacomo Zanus Francesco D’Amico Fabio Farinati Patrizia Burra Francesco Russo Paolo Angeli Davide F. D’Amico | 2010 | Digestive and Liver Disease2010，，9： | 1 |
| 15 | Endoscopic treatment of bile duct complications after orthotopic liver transplantation显示文摘 | Polese L Cillo U Brolese A | 2007 | Transplant Proc2007，39，6： | 1 |
| 16 | Endovascular treatment of acute pseudoaneurysm associated to pancreaticoduodenectomy 显示文摘 | Frego M Bertin M Brolese A | 2009 | Hepato- gastroenterology2009，56，96： | 1 |
| 17 | A simple, sensitive and wide- ly applicable ELISA for S100B: Methodological features of the measurement of this glial protein显示文摘 | Leite MC Galland F Brolese G | 2008 | J Neurosci Methods2008，169，： | 1 |
| 18 | Laparoscopic treatment of simple hepatic cysts and polycystic liver disease显示文摘 | P. Fiamingo U. Tedeschi M. Veroux U. Cillo A. Brolese A. Da Rold C. Madia G. Zanus D.F. D’Amico | 2003 | Surgical Endoscopy2003，，4： | 1 |
| 19 | Response to Therapy as a Criterion for Awarding Priority to Patients With Hepatocellular Carcinoma Awaiting Liver Transplantation显示文摘 | Alessandro Vitale Francesco D’Amico Anna Chiara Frigo Francesco Grigoletto Alberto Brolese Giacomo Zanus Daniele Neri Amedeo Carraro Francesco Enrico D’Amico Patrizia Burra Francesco Russo Paolo Angeli Umberto Cillo | 2010 | Annals of Surgical Oncology2010，，9： | 1 |
| 20 | A simple, sensitive and widely applicable ELISA for S100B: Methodological features of the measurement of this glial protein显示文摘 | Leite M C Galland F Brolese G | 2008 | J Neurosci Methods2008，169，1： | 1 |
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