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| 1 | Sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study显示文摘BACKGROUND Direct-acting antiviral agents(DAAs)are extremely effective in eradicating hepatitis C virus(HCV)in chronically infected patients.However,the protective role of the sustained virologic response(SVR)achieved by second-and thirdgeneration DAAs against the onset of hepatocellular carcinoma(HCC)and mortality is less well established.AIM To examine the occurrence of HCC or death from any cause in a retrospectiveprospective study of patients treated with DAAs.METHODS Patients were enrolled from a tertiary academic hospital center for liver disease management that collects subject data mainly from northeastern Italy.The study was conducted in 380 patients(age:60±13 years,224 males,32%with cirrhosis)treated with DAAs with or without SVR(95/5%),with a median follow up of 58 wk(interquartile range:38-117).The baseline anthropometric features,HCV viral load,severity of liver disease,presence of extra-hepatic complications,coinfection with HIV and/or HBV,alcohol consumption,previous interferon use,alphafetoprotein levels,and renal function were considered to be confounders.RESULTS The incidence rate of HCC in patients with and without SVR was 1.3 and 59 per 100 person-years,respectively(incidence rate ratio:44,95%CI:15-136,P<0.001).Considering the combined endpoint of HCC or death from any cause,the hazard ratio(HR)for the SVR patients was 0.070(95%CI:0.025-0.194,P<0.001).Other independent predictors of HCC or death were low HCV viremia(HR:0.808,P=0.030),low platelet count(HR:0.910,P=0.041),and presence of mixed cryoglobulinemia(HR:3.460,P=0.044).Considering SVR in a multi-state model,the independent predictors of SVR achievement were absence of cirrhosis(HR:0.521,P<0.001)and high platelet count(HR:1.019,P=0.026).Mixed cryoglobulinemia predicted the combined endpoint in patients with and without SVR(HR:5.982,P=0.028 and HR:5.633,P=0.047,respectively).CONCLUSION DAA treatment is effective in inducing SVR and protecting against HCC or death.A residual risk of HCC persists in patients with advanced liver disease or with complications,such as mixed cryoglobulinemia or renal failure. | Gian Luca Colussi Debora Donnini Rosario Francesco Brizzi Silvia Maier Luca Valenti Cristiana Catena Alessandro Cavarape Leonardo Alberto Sechi Giorgio Soardo | 2019 | World Journal of Gastroenterology2019，25，40： | 4 |
| 2 | 超声内镜在胰腺癌中的应用现状与展望显示文摘胰腺疾病的诊治在临床上一直是一个难点。在过去的几年中我们见证了放射学和核医学成像的技术进步。考虑到这一点,我们尝试描述超声内镜(EUS)在胰腺癌(PC)诊断及分期的过程中新的角色。到目前为止对于PC最准确的成像技术是对比增强计算机断层扫描(CT)和EUS。后者在检测微小病灶及评估肿瘤大小和淋巴结情况时具有最高的精度,但对于一个可疑的胰腺病变的患者而言,螺旋CT或最新的磁共振成像(MRI)仍是首要的选择。如在CT、MRI扫描为阴性结果而临床上高度怀疑PC,或是CT/MRI扫描后可疑病变需细胞组织学确认时,可应用EUS。相信在不久的将来用于诊断和治疗胰腺疾病的EUS将有更大的发展空间,并且病理结果将为其提供最好的应用证据。 | Claudio De Angelis Rosario Francesco Brizzi Rinaldo Pellicano 冯铁成 李新营 | 2014 | 中国普通外科杂志2014，23，3： | 2 |
| 3 | Long-term epidural analgesia treatment in pre-eclamptic women:a preliminary trial显示文摘 | Malvasi A Tinelli A Brizzi A | 2009 | J Obstet Gynaecol2009，29，2： | 1 |
| 4 | Identication of hematopoietic progenitor cells in human amniotic fluid before the 12th week of gestation显示文摘 | Torricelli F Brizzi L Bernabei PA | 1993 | Ital J Anat Embryol1993，98，2： | 1 |
| 5 | Lipoprotein metabolism during normal pregnancy显示文摘 | Brizzi P Tonolo G Esposito F | 1999 | Am J Obstet Gynecol1999，181，2： | 1 |
| 6 | The Trp64Arg beta 2 adrener- gic receptor amino acid variant confers increased sensitivity to the presser effects of noradrenaline in Sardinian subjects显示文摘 | Melism G Secchi G Brizzi P | 2002 | Clin Sci (Lord)2002，103，： | 1 |
| 7 | Low-dose dexamethasone in the rat:a model to study insulin rasistance显示文摘 | Brizzi P Solinss A | 2002 | Am J Physiol Endocrinol Metab2002，283，2： | 1 |
| 8 | Intrapartum sonography head transverse and pasynclitic diagnosis with and without epidural analgesia initiated early during the first stage of labor显示文摘 | Malvasi A Tinelli A Brizzi A | 2011 | Eur Rev Med Pharmacol Sci2011，15，5： | 1 |
| 9 | Intrapartum sonography for occiput posterior detection in early low dose combined spinal epidural analgesia by sufentanil and ropivaeaine 显示文摘 | Malvasi A Tinelli A Brizzi A | 2010 | Eur Rev Med Pharmacol Sci2010，14，9： | 1 |
| 10 | Down-regulation of phosphatidylinositol3-kinase/AKT/molecular target of Rapamycin metabolic pathway by primary Letrozole-based therapy in human breast cancer显示文摘 | Generali D Fox SB Brizzi MP | 2008 | Clin Cancer Res2008，14，9： | 1 |
| 11 | Feasibility of endovascular and surface cooling strategies in acute stroke显示文摘 | Ovesen C Brizzi M Pott FC | 2013 | Acta Neurol Scand2013，127，6： | 1 |
| 12 | Autoantibodies against oxidozed low-density lipoprotein ( ox-LDL ) and LDL oxidation status 显示文摘 | Brizzi P Tonolo G Bertrand G | 2004 | Clin Chem Lab Med2004，42，： | 1 |
| 13 | Extracellular matrix, integrins, and growth factors as tailors of the stem cell niche显示文摘 | Maria Felice Brizzi Guido Tarone Paola Defilippi | 2012 | Current Opinion in Cell Biology2012，，5： | 1 |
| 14 | Myositis ossificans circumscrip- ta : a paediatric case and review of the literature 显示文摘 | Micheli A Trapani S Brizzi 1 | 2009 | Eur J Pediatr2009，168，： | 1 |
| 15 | Six-year stabilisation of a relapsed pelvic mass from rectal cancer after oxaliplatin-containing chemotherapy 显示文摘 | Tampellini M Brizzi MP Bitossi R | 2007 | J Cancer Res Clin Oncol2007，133，10： | 1 |
| 16 | Specialized mucous glands and their possible adaptive role in the males of some species of Rana (Amphibia,Anura)显示文摘 | Brizzi R Delfino G Pellegrini R | 2002 | Journal of Morphology2002，254，3： | 1 |
| 17 | Randomized phase II trial of letrozole and letrozole plus low-dose metronomic oral cyclophosphamide as primary systemic treatment in elderly breast cancer patients 显示文摘 | Bottini A Generali D Brizzi MP | 2006 | J Clin Oncol2006，24，22： | 1 |
| 18 | Thyroid hormone plasmatic levels in rats treated with serotionin in acute and chronic way显示文摘 | G Brizzi C Carellab MC Foglia | 1997 | Jphysiology (Paris)1997，91，： | 1 |
| 19 | Low-dose dexamethasone in the rat:a model to study insulin resistance显示文摘 | Severino C Brizzi P Solinas A | | 0，，02： | 1 |
| 20 | HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias andregulate cell proliferation of normal and leukemic hemopoietic progenitors显示文摘 | PILLOZZI S BRIZZI M F BALZI M | 2002 | Leukemia2002，16，： | 1 |
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