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| 1 | Targeted therapies in metastatic gastric cancer: Current knowledge and future perspectives显示文摘Gastric cancer(GC)represents a leading cause of cancer related morbidity and mortality worldwide accounting for more than 1 million of newly diagnosed cases and thousands of deaths every year.In the last decade,the development of targeted therapies and the optimization of already available chemotherapeutic drugs has expanded the available treatment options for advanced GC and granted better survival expectations to the patients.At the same time,global efforts have been undertaken to investigate in detail the genomic and epigenomic heterogeneity of this disease,resulting in the identification of new specific and sensitive predictive and prognostic biomarkers and in innovative molecular classifications based on gene expression profiling.Nonetheless,several randomized studies aimed at exploring new innovative agents,such as immune checkpoint inhibitors,failed to demonstrate clinically meaningful survival advantages.Therefore,it is essential to further improve the molecular characterization of GC subgroups in order to provide researchers and medical oncologists with new tools for patients’selection and stratification in future clinical development programs and subsequent trials.The aim of the present manuscript is to provide a global overview of the recent molecular classifications from The Cancer Genome Atlas and the Asian Cancer Research Group and to present key promising developments in the field of immunotherapy and targeted therapies in metastatic GC. | Antonio Pellino Erika Riello Floriana Nappo Stefano Brignola Sabina Murgioni Selma Ahcene Djaballah Sara Lonardi Vittorina Zagonel Massimo Rugge Fotios Loupakis Matteo Fassan | 2019 | World Journal of Gastroenterology2019，25，38： | 9 |
| 2 | Polyunsaturated fatty acids and inflammatory bowel disease显示文摘 | BELLUZZI A BOSCHI S BRIGNOLA C | 2000 | The American Journal of Clinical Nutrition2000，71，： | 1 |
| 3 | DNA methylating and demethylating treatments modify phenotype and cell wall differentiation state in sugarbeet cell lines显示文摘 | Adisa Causevic Alain Delaunay Sa?da Ounnar Michel Righezza Francis Delmotte Franck Brignolas Daniel Hagège Stéphane Maury | 2005 | Plant Physiology and Biochemistry2005，，7： | 1 |
| 4 | Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease显示文摘 | Belluzzi A Brignola C Campieri M | 1996 | N Engl J Med1996，334，24： | 1 |
| 5 | Polyunsaturated fatty acids and inflammatory bowel disease显示文摘 | BELLUZZI A BOSCHI S BRIGNOLA C | 2000 | Am J Clin Nntr2000，，： | 1 |
| 6 | Scavenger effect of sulfasalazine, 5-aminosalicylic acid, and olsalazine on superoxide radical generation显示文摘 | P. Gionchetti MD C. Guarnieri MD M. Campieri MD A. Belluzzi MD C. Brignola MD P. Iannone MD M. Miglioli MD L. Barbara MD | 1991 | Digestive Diseases and Sciences1991，，2： | 1 |
| 7 | Effectiveness of 5-aminosalicylic acid for maintaining remission in patients with Crohn's disease: a meta-analysis显示文摘 | Messori A Brignola C Trallori G | 1994 | Am J Gastroenterol1994，89，： | 1 |
| 8 | Changes in phenolic metab- olites of Scots-pine phloem induced by Ophiostonw brunneociliatum, a bark-beetle-associated fungus 显示文摘 | LIEUTIER F SAUVARD D BRIGNOLAS F | 1996 | European Journal of Pathology1996，26，3： | 1 |
| 9 | Induced responses in phenolic metabolism in two Norway spruce clones after wounding and inoculations with Ophiostoma polonicum, a bark beetle-associated fungus 显示文摘 | Brignolas F Lacroix B Lieutier F | 1995 | Plant Physiol1995，109，3： | 1 |
| 10 | Treatment of ulcerative colitis with high-dose 5-aminosalicyclic acid enemas显示文摘 | Campieri M Lanfranchi GA Bazzocchi G Brignola C Sarti F Franzin G Battocchia A Labo G Dal MontePR | 1981 | Lancet1981，45，8： | 1 |
| 11 | Effect of an enteric- coated fish-oil preparation on relapses in Crohn's disease显示文摘 | Belluzzi A Brignola C Campieri M | 1996 | N Engl J Med1996，334，24： | 1 |
| 12 | Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease显示文摘 | Belluzzi A Brignola C Campieri M | 1996 | N Engl J Med1996，334，： | 1 |
| 13 | Effect of an enteric-coated fish-oil preparation on relapses in crohn's disease显示文摘 | Belluzzi A Brignola C 'Campieri M | 1996 | N Engl J Med1996，334，24： | 1 |
| 14 | Polyunsaturated fatty acids and inflammatory bowel disease显示文摘 | Belluzzi A Boschi S Brignola C | 2000 | Am J Clin Nutr2000，71，1： | 1 |
| 15 | Mucosal concentrations of interleukin-1β, interleukin-6, interleukin-8, and tumor necrosis factor-α in pelvic ileal pouches显示文摘 | Dr. P. Gionchetti MD M. Campieri MD A. Belluzzi MD E. Bertinelli MD M. Ferretti MD C. Brignola MD G. Poggioli MD M. Miglioli MD L. Barbara MD | 1994 | Digestive Diseases and Sciences1994，，7： | 1 |
| 16 | Impact of drought and productivity and water use efficiency in 29 genotypes of Populus deltoids x Populus nigra 显示文摘 | MONCLUS R DREYER E VILLAR M DELMOTI?E F M DE- LAY D PETIT J M BARBAROUX C THIEC D L B-RECHET C BRIGNOLAS F | 2005 | New Phytologist2005，169，： | 1 |
| 17 | Placebo-controlled trial of oral 5-ASA in relapse prevention of Crohn's disease显示文摘 | Brignola C Lannone P Pasquali S | 1992 | Dig Dis Sci1992，37，1： | 1 |
| 18 | Polyunsaturated fatty acids and inflammatory bowel disease显示文摘 | Belluzzi A Boschi S Brignola C | 2000 | Am J Clin Nutr2000，71，1： | 1 |
| 19 | Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease显示文摘 | Belluzzi A Brignola C Campieri M | | 0，，24： | 1 |
| 20 | Scavenger effect of sulfasalazine, 5-aminosalicylic acid and olsalazine on superoxide radical generation显示文摘 | Gionchetti P Guarnieri C Campieri M Belluzzi A Brignola C Oannone P | 1991 | Dig Dis Sci1991，36，： | 1 |
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