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| 1 | Clinical epidemiology and disease burden of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is defined as the presence of hepatic fat accumulation after the exclusion of other causes of hepatic steatosis, including other causes of liver disease, excessive alcohol consumption, and other conditions that may lead to hepatic steatosis. NAFLD encompasses a broad clinical spectrum ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis(NASH), advanced fibrosis, cirrhosis, and finally hepatocellular carcinoma(HCC). NAFLD is the most common liver disease in the world and NASH may soon become the most common indication for liver transplantation. Ongoing persistence of obesity with increasing rate of diabetes will increase the prevalence of NAFLD, and as this population ages, many will develop cirrhosis and end-stage liver disease. There has been a general increase in the prevalence of NAFLD, with Asia leading the rise, yet the United States is following closely behind with a rising prevalence from 15% in 2005 to 25% within 5 years. NAFLD is commonly associated with metabolic comorbidities, including obesity, type Ⅱ diabetes, dyslipidemia, and metabolic syndrome. Our understanding of the pathophysiology of NAFLD is constantly evolving. Based on NAFLD subtypes, it has the potential to progress into advanced fibrosis, end-stage liver disease and HCC. The increasing prevalence of NAFLD with advanced fibrosis, is concerning because patients appear toexperience higher liver-related and non-liver-related mortality than the general population. The increased morbidity and mortality, healthcare costs and declining health related quality of life associated with NAFLD makes it a formidable disease, and one that requires more in-depth analysis. | Brandon J Perumpail Muhammad Ali Khan Eric R Yoo George Cholankeril Donghee Kim Aijaz Ahmed | 2017 | World Journal of Gastroenterology2017，23，47： | 70 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | Recent advances in the diagnostic evaluation of pancreatic cystic lesions显示文摘Pancreatic cystic lesions(PCLs)are becoming more prevalent due to more frequent abdominal imaging and the increasing age of the general population.It has become crucial to identify these PCLs and subsequently risk stratify them to guide management.Given the high morbidity associated with pancreatic surgery,only those PCLs at high risk for malignancy should undergo such treatment.However,current diagnostic testing is suboptimal at accurately diagnosing and risk stratifying PCLs.Therefore,research has focused on developing new techniques for differentiating mucinous from non-mucinous PCLs and identifying high risk lesions for malignancy.Cross sectional imaging radiomics can potentially improve the predictive accuracy of primary risk stratification of PCLs at the time of detection to guide invasive testing.While cyst fluid glucose has reemerged as a potential biomarker,cyst fluid molecular markers have improved accuracy for identifying specific types of PCLs.Endoscopic ultrasound guided approaches such as confocal laser endomicroscopy and through the needle microforceps biopsy have shown a good correlation with histopathological findings and are evolving techniques for identifying and risk stratifying PCLs.While most of these recent diagnostics are only practiced at selective tertiary care centers,they hold a promise that management of PCLs will only get better in the future. | Devarshi R Ardeshna Troy Cao Brandon Rodgers Chidiebere Onongaya Dan Jones Wei Chen Eugene J Koay Somashekar G Krishna | 2022 | World Journal of Gastroenterology2022，28，6： | 3 |
| 4 | A neural networks of carrot tip classification显示文摘 | Brandon J R Howarth M S Searcy S W | 1990 | Trans of the ASAE1990，，： | 1 |
| 5 | Validation of a sensitive LC-MS/MS method for the determination of zidovudine and lamivudine in human plasma显示文摘 | JOSEPH E R BRANDON K LANE R B | 2012 | Biomed Chromatogr2012，26，1： | 1 |
| 6 | Osmium recycling in subduction zones显示文摘 | Creaser R A Shirey S B | 1996 | Science1996，272，： | 1 |
| 7 | Properties of bulk polycrystalline CVD diamond显示文摘 | Sussmann R S Brandon J R Scarsbrook G A | 1994 | Diamond and Related Materials1994，，3： | 1 |
| 8 | 186Os-187Os systematics of Gorgona Island komatiites:implications for early growth of the inner core显示文摘 | Walker R J Puchtel I S | 2003 | Earth and Planetary Science Letters2003，206，34： | 1 |
| 9 | Systemic Par-4 inhibits non-autochthonous tumor growth 显示文摘 | Zhao Y Burikhanov R Brandon J | 2011 | Cancer Biol Ther2011，12，2： | 1 |
| 10 | Modelling of cells,stacks and systems based around metal-supported planar IT-SOFC cells with CGO electrolytes operating at 500 ~ 600 ℃显示文摘 | LEAH R T BRANDON N P AGUIAR P | 2005 | Power Sources2005，145，2： | 1 |
| 11 | Mierostructure,compos-ition and property relationship of plasma-sprayed thermal barrier coatings 显示文摘 | Taylor R Brandon J R | 1992 | Surface and Coatings Technology1992，50，： | 1 |
| 12 | A novel approach to process modeling for instrument surveillance and calibration verification 显示文摘 | BRANDON R WESLEY H ROBERT E U | 2003 | Nuclear Technology2003，，2： | 1 |
| 13 | Subpopulation of lymphocytes in the mammary gland of sheep显示文摘 | Lee C S Meeusen E Brandon M R | 1989 | Immunology1989，66，： | 1 |
| 14 | Maternal and fetal repre- sentations, dimensions of personality, and prenatal attachment in women hospitalized with high-risk pregnancy显示文摘 | Brandon AR Pitts S Robinson R | 2007 | J Am Psyehoanal Assoc2007，55，1： | 1 |
| 15 | Micro structure, composition and relationships of plasmasprayed thermal barrier coatings 显示文摘 | TAYLOR R BRANDON R MORRELL P | 1992 | Surface and Costings Technology1992，50，： | 1 |
| 16 | Osmium recycling in subduction zones显示文摘 | BRANDON A D CREASER R A SHIREY S B | 1996 | Science1996，272，： | 1 |
| 17 | Estimation of tip shape for carrot classification by machine vision显示文摘 | Howarth M S Brandon J R Searcy S W | 1992 | Journal of Agricultural Engineering Research1992，53，： | 1 |
| 18 | Irradiation uniformity of directly driven inertial confinement fusion targets in the context of the shock-ignition scheme显示文摘 | M Temporal R Ramis B Canaud V Brandon S Laffite B J Le Garrec | 2011 | Plasma Physics and Controlled Fusion2011，，12： | 1 |
| 19 | Modeling of ceils, stacks and systems based around metal-supported planar IT-SOFC cells with CGO electrolytes operating at 500-600显示文摘 | Leah R T Brandon N P Aguiar P | 2005 | Journal of Power Sources2005，145，2： | 1 |
| 20 | Development of Tolerance to the Dietary Plant Secondary Metabolite 1, 8-Cin- cole by the Brushtail Possum ( Trichosurus vulpecula) 显示文摘 | MCLEAN S BRANDON S BOYLE R R | 2008 | Journal of Chemical Ecology2008，34，5： | 1 |
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