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| 1 | TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization显示文摘皮肤的神经原的发炎(CNI ) 是被导致的发炎(或提高) 在由从感觉神经末端的 neuropeptides 的版本的皮肤。临床的表明主要是象瘙痒和红斑那样的感觉、脉管的混乱。短暂受体潜力 vanilloid 1 并且 ankyrin 1 (TRPV1 和 TRPA1,分别地) 是知道明确地参予疼痛和 CNI 的非选择的阳离子隧道。TRPV1 和 TRPA1 在感觉神经的一个大子集被共同表示,在他们集成众多的有害刺激的地方。两条隧道的表示也在皮肤在感觉神经以外远延长,现在是清楚的,在 keratinocytes,桅杆房间,树枝状的房间,和 endothelial 房间也发生。在这些 non-neuronal 房间, TRPV1 和 TRPA1 也充当 nociceptive 传感器并且加强煽动性的过程。这评论在在感觉神经原和 non-neuronal 皮肤房间导致或维持 CNI 的煽动性的基因的调整讨论 TRPV1 和 TRPA1 的角色。另外,这评论由支持 CNI 的自我维护的另外的内长的煽动性的调停人提供关于两条 TRP 隧道的细胞内部的促进感受性小径的当前的研究的一篇摘要。 | Olivier Gouin Killian L'Herondelle Nicolas Lebonvallet Christelle Le Gall-lanotto Mehdi Sakka Virginie Buhe Emmanuelle PIee-Gautier Jean-Luc Carre Luc Lefeuvre Laurent Misery~,Raphaele Le Garrec | 2017 | Protein & Cell2017，8，9： | 45 |
| 2 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 3 | Neuropathic pruri-rus显示文摘 | Misery L Brenaut E Le Garrec R | 2014 | Nat Rev Neurol2014，10，7： | 1 |
| 4 | Neuropathic pruritus 显示文摘 | Misery L Brenaut E Le Garrec R | 2014 | Nat Rev Neurol2014，10，7： | 1 |
| 5 | Irradiation uniformity of directly driven inertial confinement fusion targets in the context of the shock-ignition scheme显示文摘 | M Temporal R Ramis B Canaud V Brandon S Laffite B J Le Garrec | 2011 | Plasma Physics and Controlled Fusion2011，，12： | 1 |
| 6 | N-Isopropylacrylamide copolymers for the preparation of pH-sensitive liposomes and polymeric micelles 显示文摘 | Leroux JC Roux E Le Garrec D | 2001 | J Controlled Release2001，72，13： | 1 |
| 7 | Multi kJ level Laser Concepts for HiPER Facility显示文摘 | J-C Chanteloup D Albach A Lucianetti K Ertel S Banerjee P D Mason C Hernandez-Gomez J L Collier J Hein M Wolf J K?rner B J Le Garrec | 2010 | Journal of Physics: Conference Series2010，，1： | 1 |
| 8 | Fusegates increase storage capacity at four dams in Gujarat显示文摘 | GARREC P | 1998 | Hydropower and Dams1998，，5： | 1 |
| 9 | New dry friction model with load and velocity-dependence and dynamic identification of multi-DOF robots显示文摘 | Hamon P Gautier M Garrec P | 2011 | International Conference on Robotics and Automation2011，9，13： | 1 |
| 10 | Enumeration of Bacteroides species in human faeces by fluorescent in situ hybridization combined with flow cytometry using 16S rRNA probes显示文摘 | Rigottier-Gois L Rochet V Garrec N | | 0，，1： | 1 |
| 11 | Chemicals on the leaf surface, information about the plant available to insects显示文摘 | S. Derridj B. R. Wu L. Stammitti J. P. Garrec A. Derrien | 1996 | Entomologia Experimentalis et Applicata1996，，1： | 1 |
| 12 | Neuropathic pruritus 显示文摘 | Laurent Misery Emilie-renaut Raphage Le Garrec | 2014 | Nature Review Neurology2014，10，： | 1 |
| 13 | Poly(N-vinylpyrrolidone)block-poly(d,l-lactide)as a new polymeric solubilizer for hydrophobic anticancer drugs:in vitro and in vivo evaluation显示文摘 | Garrec DL Gori S Luo L | 2004 | Joumal of Controlled Release2004，99，： | 1 |
| 14 | Fluoride Absorption by the Root and Foliar Tissues of the Horse-bean ( Calciole ) and Lupin ( Calcifuge ) : Preliminary Studies 显示文摘 | Garrec J P Letourneur L | 1981 | Fluoride1981，14，1： | 1 |
| 15 | Poly (N-vinylpyrrolidone)-block-poly (D, L-lactide) as a new polymeric solubilizer for hydrophobic anticancer drugs: in vitro and in vivo evaluation 显示文摘 | Le Garrec D Gori S Luo L | 2004 | Journal of Controlled Release2004，99，1： | 1 |
| 16 | Unexpected frequency of Upshaw-Sehulman syndrome in pregnancy-onset thrombotic thrombocytopenic pur- pura显示文摘 | MOATTIi-COHEN M GARREC C WOLF M | 2012 | Blood2012，119，： | 1 |
| 17 | Can tumor necrosis factor inhibitors induce sclero-uveitis? 显示文摘 | Le Garrec J Marcelli C Mouriaux F | 2009 | J Fr Ophtal- mol2009，32，7： | 1 |
| 18 | Optimizing pH-responsive polymeric micelles for drug delivery in a cancer photodynamic therapy model 显示文摘 | Le Garrec D Taillefer J Van Lier JE | 2002 | JDrug Target2002，10，5： | 1 |
| 19 | Unexpected frequency of Upshaw-Schulman syndrome in pregnancy-onset thrombotic thrombocytopenic pur pura 显示文摘 | Moatti-Cohen M Garrec C Wolf M | 2012 | Blood2012，119，24： | 1 |
| 20 | A thermo-sensitive chitosan-based hydrogel for the local delivery of paclitaxel显示文摘 | Ruel-Garie'py Shive M Bichara A Berrada M Garrec DL Chenite A | 2004 | Eur J Pharm Biopharm2004，57，： | 1 |
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