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| 1 | Kynurenine pathway metabolism and neuroinflammatory disease显示文摘Immune-mediated activation of tryptophan(TRYP) catabolism via the kynurenine pathway(KP) is a consistent finding in all inflammatory disorders.Several studies by our group and others have examined the neurotoxic potential of neuroreactive TRYP metabolites,including quinolinic acid(QUIN) in neuroinflammatory neurological disorders,including Alzheimer's disease(AD),multiple sclerosis,amylotropic lateral sclerosis(ALS),and AIDS related dementia complex(ADC).Our current work aims to determine whether there is any benefit to the affected individuals in enhancing the catabolism of TRYP via the KP during an immune response.Under physiological conditions,QUIN is metabolized to the essential pyridine nucleotide,nicotinamide adenine dinucleotide(NAD+),which represents an important metabolic cofactor and electron transporter.NAD+ also serves as a substrate for the DNA ‘nick sensor' and putative nuclear repair enzyme,poly(ADP-ribose) polymerase(PARP).Free radical initiated DNA damage,PARP activation and NAD+ depletion may contribute to brain dysfunction and cell death in neuroinflammatory disease. | Nady Braidy Ross Grant | 2017 | Neural Regeneration Research2017，12，1： | 6 |
| 2 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 3 | Reexamining the role of recasts in native- speaker/nonnative-speaker interactions 显示文摘 | Braidi S M | 2002 | Language Learning2002，，52： | 1 |
| 4 | Age related changes inNAD+metabolism oxidative stress and Sirt1 activity in wistar rats显示文摘 | Braidy N Guillemin GJ Mansour H | 2011 | PLoS One2011，6，19： | 1 |
| 5 | Careful examination of thyroid specimen intraoperatively to reduce incidence of inadvertent parathyroidectomy during thyroid surgery显示文摘 | Abboud B Sleilaty G Braidy C | 2007 | Arch Otolaryngol Head Neck Surg2007，133，11： | 1 |
| 6 | Effect of laser intensity on yield and physical characteristics of single wall carbon nanotubes produced by the Nd:YAG laser vaporization method显示文摘 | N BRAIDY | 2002 | Carbon2002，40，： | 1 |
| 7 | Careful examination of thyroid specimen intraoperatively to reduce incidence of inadvertent parathyroidectomy during thyroid surgery 显示文摘 | Abboud B Sleilaty G Braidy C | 2007 | Arch Otolaryngol Head Neck Surg2007，133，11： | 1 |
| 8 | Reexamining the role of recasts in native-speaker/normative-speaker interactions 显示文摘 | Braidi S M | 2002 | Language Learning2002，52，1： | 1 |
| 9 | Differential ex- pression of sirtuins in the aging rat brain 显示文摘 | BRAIDY N POLJAK A GRANT R | 2015 | Front Cell Neurosci2015，9，： | 1 |
| 10 | Recent rodent mod- els for Alzheimer' s disease: clinical implications and basic research 显示文摘 | Braidy N Mufioz P Palacios A G | 2012 | J Neural Transm2012，119，2： | 1 |
| 11 | 查看详情显示文摘 | Yao Z Braidy N Botton G.A Adronov A | | 0，，51： | 1 |
| 12 | Equilibrium and stability of phase-separating Au-Pt nanoparticles显示文摘 | Braidy N Purdy G R Botton G A | | 0，，20： | 1 |
| 13 | Neuroprotective effects of chrysin: from chenfistry to medicine显示文摘 | Nabavi SF Braidy N Habtemariam S | 2015 | Neurochem Int2015，90，： | 1 |
| 14 | Neuroprotective effects of ginkgolide B against ischemic stroke:A review of current literature显示文摘 | NABAVI SM HABTEMARIAM S DAGHA M BRAIDY N LOEZO MR TUNDIS R | 2015 | Curr Top Med Chem2015，15，21： | 1 |
| 15 | Polymerization from the surface of single-walled carbon nanotubes-preparation and characterization of nanocomposites显示文摘 | Yao Z Braidy N Botton G A | 2003 | J Am Chem Soc2003，125，16： | 1 |
| 16 | Reexamining the role of recasts in native speaker /non-native speaker interactions显示文摘 | Braidi S.M | | 0，，： | 1 |
| 17 | Unenhanced MR angiography of renal arteries:51 patients显示文摘 | Braidy C Daou I Diop AD | 2012 | AJR Am J Roentgenol2012，199，5： | 1 |
| 18 | Diet rich in date palm fruits improves memory,learning and reduces beta amyloid in transgenic mouse model of Alzheimer′s disease显示文摘 | Subash S Essa MM Braidy N Awlad-Thani K Vaishnav R Al-Adawi R | 2015 | J Ayurveda Integr Med2015，6，2： | 1 |
| 19 | Reexaminingtheroleofrecastsinnative-speaker/nonnative-speakerinteractions显示文摘 | Braidi S.M | | 0，，01： | 1 |
| 20 | Extraovarian cysta- denomas : ultrasound and MR findings in 7 cases显示文摘 | Ghossain MA Braidy CG Kanso HN | 2005 | J Comput Assist Tomogr2005，29，1： | 1 |
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