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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Real-life chromoendoscopy for dysplasia surveillance in ulcerative colitis显示文摘AIM To evaluate the use of chromoendoscopy for surveillance of ulcerative colitis in a real-life community hospital setting.METHODS Patients with extensive ulcerative colitis, having disease duration of more than 8 years and who presented between the years of 1999 to 2013, were offered enrolment in this single cohort prospective study. All participants underwent standard bowel preparation with sodium phosphate and chromoendoscopy. Two expert endoscopists, novice to chromoendoscopy, evaluated each segment of the colon with standarddefinition colonoscopes after spray application of 0.4% indigo carmine. All observed lesions were recorded and evaluated before being removed and/or biopsied. In addition, nontargeted biopsies were taken from each segment of the colon. The dysplasia detection rate and dysplasia detection yield were ascertained. RESULTS A total of 21 neoplastic lesions(2 carcinomas, 4 of high-grade dysplasia and 15 of low-grade dysplasia) and 27 nondysplastic lesions were detected in 16 of the total 67 patients(70% male; median disease duration: 17 years; median age at diagnosis: 25 years; 92% aminosalicylate-treated). The dysplasia detection rate was 10.5%(7/67 patients). The dysplasia detection yield was 20.8%(10/48) for targeted biopsies and 3.5%(11/318) for nontargeted biopsies. The sensitivity and specificity for the macroscopic evaluation of neoplasia using chromoendoscopy were 48% [95% confidence interval(CI): 26%-70%] and 96%(95%CI: 93%-98%), respectively. The positive predictive and negative predictive values were 42%(95%CI: 27%-59%) and 97%(95%CI: 95%-98%), respectively. A total of 19/21 dysplastic lesions were detected in mucosa with histologic inflammation.CONCLUSION Chromoendoscopy seems to be of value for dysplasia surveillance of ulcerative colitis in a community hospital setting. The yield of non-targeted biopsies is negligible. | Pasquale Klepp Anita Tollisen Arne Roseth Milada Cvancarova Smastuen Solveig N Andersen Morten Vatn Bjorn A Moum Stephan Brackmann | 2018 | World Journal of Gastroenterology2018，24，35： | 3 |
| 3 | Ripening and senescence of papaya with 1 methylcyclopropene 显示文摘 | Jacomino A P Kluge R A Brackmann A | 2002 | Scientia Agricola2002，59，2： | 1 |
| 4 | Reconstruction of the andiogram using brain stem responses and high - pass noise masking显示文摘 | Don M Eggermont JJ Brackmann DE | 1979 | Ann Otol Rhinol Laryngol Suppl1979，57，： | 1 |
| 5 | Parvovirus B19 DNA contamination in coagulation factor Ⅷ products 显示文摘 | Eis-Hubinger AM Sasowski U Brackmann HH | 1999 | Thromb Haemost1999，81，3： | 1 |
| 6 | Brainstem potentials evoked by electrical stimulation of the cochlear in human subjects 显示文摘 | Starr A Brackmann DE | 1979 | Ann Otol Rhinol Laryngoh1979，88，： | 1 |
| 7 | Facial never grading system 显示文摘 | House JW Brackmann DE | 1985 | Otolaryngol Head Neck Surg1985，93，2： | 1 |
| 8 | Facial never grading systems显示文摘 | House JW Brackmann DE | 1983 | Laryngoscope1983，93，： | 1 |
| 9 | Reclassification of aggressive adenomatous mastoid neoplasms as endolymphatic sac tumors显示文摘 | Li J C Brackmann D E Lo W W | 1993 | Laryngoscope1993，103，12： | 1 |
| 10 | Reclassification of aggres sive adenomatous mastoid neoplasms as endolymphatic sac tumors显示文摘 | Li JC Brackmann DE Lo WW | 1993 | Laryngoscope1993，103，12： | 1 |
| 11 | Facial nerve grading system 显示文摘 | HOUSE J BRACKMANN D | 1985 | Otolaryngol Head Neck Surg1985，，14： | 1 |
| 12 | Report of 190 consecutive case of large acoustic tumors (vestibular schwannoma) removed via the translabyrinthine approach 显示文摘 | Lanman TH Brackmann DE Hitselberger WE | 1999 | J Neurosurg1999，90，4： | 1 |
| 13 | Facial nerve grading system显示文摘 | House JW Brackmann DE | 1985 | Otolaryngol Head Neck Surg1985，93，： | 1 |
| 14 | Microvascular decom- pression of the vestibulocochlear nerve for disabling positional vertigo: the House Ear Clinic experience显示文摘 | Brackmann DE Kesser BW Day JD | 2001 | Otol Neurotol2001，22，6： | 1 |
| 15 | Immune tolerance for the treatment of factor V~ inhibitors-twenty years' 'bonn protocol' 显示文摘 | BRACKMANN H H OLDENBURG J SCHWAAB R | 1996 | Vox Sang1996，70，1： | 1 |
| 16 | Facial nerve grading system显示文摘 | House JW Brackmann DE | 1985 | Otolaryngol Head Neck Surg1985，93，2： | 1 |
| 17 | Immune tolerance induction: a role for recombinant activated factor Ⅶ (rFⅦa)显示文摘 | Brackmann HH Effenberger W Hess L | 1998 | Em J Haemotol1998，61，63： | 1 |
| 18 | Conservative facial nerve management in jugular foramen schwannomas显示文摘 | Cokkeser Y Brackmann DE Fayad JN | 2000 | Am J Otol2000，21，2： | 1 |
| 19 | A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma显示文摘 | Caceres A I Brackmann M Ella M D | 2009 | Proc Natl Acad Sci U S A2009，106，22： | 1 |
| 20 | Pressure neuropathy of the facial nerve:a case report with light and electron microscopic findings显示文摘 | Ylikoski J Brackmann DE Savolainen S | | 0，，： | 1 |
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