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| 1 | Metabolic derivatives of alcohol and the molecular culpritsof fibro-hepatocarcinogenesis:Allies or enemies?显示文摘Chronic intake of alcohol undoubtedly overwhelms the structural and functional capacity of the liver by initiating complex pathological events characterized by steatosis,steatohepatitis,hepatic fibrosis and cirrhosis.Subsequently,these initial pathological events are sustained and ushered into a more complex and progressive liver disease,increasing the risk of fibrohepatocarcinogenesis.These coordinated pathological events mainly result from buildup of toxic metabolic derivatives of alcohol including but not limited to acetaldehyde(AA),malondialdehyde(MDA),CYP2E1-generated reactive oxygen species,alcohol-induced gut-derived lipopolysaccharide,AA/MDA protein and DNA adducts.The metabolic derivatives of alcohol together with other comorbidity factors,including hepatitis B and C viral infections,dysregulated iron metabolism,abuse of antibiotics,schistosomiasis,toxic drug metabolites,autoimmune disease and other non-specific factors,have been shown to underlie liver diseases.In view of the multiple etiology of liver diseases,attempts to delineate the mechanism by which each etiological factor causes liver disease has always proved cumbersome if not impossible.In the case of alcoholic liver disease(ALD),it is even more cumbersome and complicated as a result of the many toxic metabolic derivatives of alcohol with their varying liver-specific toxicities.In spite of all these hurdles,researchers and experts in hepatology have strived to expand knowledge and scientific discourse,particularly on ALD and its associated complications through the medium of scientific research,reviews and commentaries.Nonetheless,the molecularmechanisms underpinning ALD,particularly those underlying toxic effects of metabolic derivatives of alcohol on parenchymal and non-parenchymal hepatic cells leading to increased risk of alcohol-induced fibrohepatocarcinogenesis,are still incompletely elucidated.In this review,we examined published scientific findings on how alcohol and its metabolic derivatives mount cellular attack on each hepatic cell and the underlying molecular mechanisms leading to disruption of core hepatic homeostatic functions which probably set the stage for the initiation and progression of ALD to fibro-hepatocarcinogenesis.We also brought to sharp focus,the complex and integrative role of transforming growth factor beta/small mothers against decapentaplegic/plasminogen activator inhibitor-1 and the mitogen activated protein kinase signaling nexus as well as their cross-signaling with toll-like receptormediated gut-dependent signaling pathways implicated in ALD and fibro-hepatocarcinogenesis.Looking into the future,it is hoped that these deliberations may stimulate new research directions on this topic and shape not only therapeutic approaches but also models for studying ALD and fibro-hepatocarcinogenesis. | Alex Boye Yu-Hong Zou Yan Yang | 2016 | World Journal of Gastroenterology2016，22，1： | 4 |
| 2 | The effect of high hydrostatic pressure on strawberry flavour compounds显示文摘 | Ioannis Zabetakis Athanasios Koulentianos Estibalitz Orru?o Ian Boyes | 2000 | Food Chemistry2000，，1： | 2 |
| 3 | Towards a new tuberculosis drug: pyridomycin – nature’s isoniazid显示文摘 | Ruben C. Hartkoorn Claudia Sala Jo?o Neres Florence Pojer Sophie Magnet Raju Mukherjee Swapna Uplekar Stefanie Boy‐R?ttger Karl‐Heinz Altmann Stewart T. Cole | 2012 | EMBO Mol Med2012，，： | 2 |
| 4 | Pulmonary alveolar microlithiasis: an interesting case report with systematic review of Indian literature显示文摘肺的牙槽的 microlithiasis 是 microliths 的 intra 牙槽的存在描绘的稀罕疾病。这研究报导肺的牙槽的 microlithiasis 的一个有趣的案例并且提供从印度报导的案例的系统的评论。与咳嗽,喘息,胸疼痛,和阵发性的喘息的历史介绍五个月的 23 岁的女性。肺的功能测试表明了一个妨碍的模式,并且胸 X 射线显示出主要包含两个肺的中间、更低的地区的好 micronodular 暗。Transbronchial 肺活体检视揭示了诊断。她对吸入的类固醇治疗作出回应很好。文学的系统的评论被执行并且鉴别肺的牙槽的 microlithiasis 的 73 个案例从印度报导了。病人的平均数(SD ) 年龄是 28.8 (14.9 ) 年,与几乎相等的 male:female 比率。许多病人在表示是无征状的。呼吸急促和咳嗽是最普通的症状,并且疾病进行了进与英国管 pulmonale 联系的呼吸失败。大约三分之一个个案例开始被误诊并且对待同样肺的肺结核。额外肺的表明和 comorbidities 在我们的系列也是明显的。这系统的评论帮助决定肺的牙槽的 microlithiasis 的流行病学、临床的特征。进一步的研究被需要阐明 etiopathogenesis,诊断,和治疗学的选择,它在为肺的牙槽的 microlithiasis 开发并且识别 costeffective 治疗是有益的。 | Nidhya Ganesan Marie Moses Ambroise Anita Ramdas King Herald Kisku Kulwant Singh Renu G' Boy Varghese | 2015 | Frontiers of Medicine2015，9，2： | 2 |
| 5 | Magnetoresistance and Hall Effect Measurements of Ni to 6 GPa显示文摘 | Boye S A Lazor P Ahuja R | 2005 | J Magne Magnetic Mater2005，294，3： | 1 |
| 6 | Remo,Jal of vegetal tannins from wastewater by electroprecipitation combined with electrogenerated Fenton oxidation 显示文摘 | Boye B Farnia G Sandona G | 2005 | J Appl Electrochem2005，35，： | 1 |
| 7 | Resolution corrected modulation:the practical realisation of ideal PWM waveforms显示文摘 | HANDLEY P G BOYS J T | 1992 | IEEE Proceedings-B1992，139，4： | 1 |
| 8 | Protein-polyphenol interactions in fruit juices显示文摘 | Boye J I | 1999 | Recent Res Devel Agricultural& Food Chem1999，，3： | 1 |
| 9 | A series-tuned inductive-power-transfer pickup with a controllable AC- voltage output显示文摘 | WU H H COVIC G A BOYS J T | 2011 | IEEE Transactions on Power Electronics2011，260，： | 1 |
| 10 | High levels of microRNA - 21 in the stroma of colorectal cancers predict short disease- free survival in stage II colon cancer patients显示文摘 | Boye Schnack Nielsen Stine J? rgensen Jacob Ulrik Fog | 2011 | Springer2011，28，： | 1 |
| 11 | Current-forced Single-phase Re- versible Rectifier显示文摘 | J T Boys A W Green | 1989 | IEEE Proceeding1989，136，5： | 1 |
| 12 | Comparison of the functional properties of pea,chickpea and lentil protein concentrates processed using ultrafiltration and isoelectric precipitation techniques显示文摘 | Boye J I Aksay S Roufik S | 2010 | Food Research International2010，43，2： | 1 |
| 13 | Changes in soymilk quality as a function of composition and storage显示文摘 | ACHOURI A BOYE J I ZAMANI Y | 2007 | Journal of Food Quality2007，30，5： | 1 |
| 14 | Microsatellite analysis reveals genetically distinct populations of red pine ( Pinus resinosa, Pina- ceae) 显示文摘 | Boys J Cherry M Dayanandan S | 2005 | American Journal of Botany2005，92，5： | 1 |
| 15 | Recent progress in studies of infantile hemangioma显示文摘 | Jinnin M Ishihara T Boye E | 2010 | J Dermaml2010，37，4： | 1 |
| 16 | A three- phase inductive power transfer system for roadway powered vehieles显示文摘 | COVIC G A BOYS J T KISSIN M L | 2007 | IEEE Transactions on Industrial Electronics2007，54，6： | 1 |
| 17 | Root morphology and nitrogen uptake of Maze simultaneously Supplied with Ammonium and Nitrate in a Split-root System显示文摘 | MARCUS SCHORTEMEYER BOY FEIL PETER STAMP | 1993 | Aannals of Botany1993，72，： | 1 |
| 18 | Adaptive functioning,behavior problems and school performance of Guatemalan children with deficient, marginal and normal plasma vitamin B12 显示文摘 | Penland J Allen LH Boy E | 2000 | FASEB J2000，14，3： | 1 |
| 19 | Protein-polyphenol interaction in fruit juices显示文摘 | BOYE J L | 1999 | Agricultural And Food Chem1999，，3： | 1 |
| 20 | Flow cytometric evaluation of postmortem pulp DNA degradation显示文摘 | Boy SC Bernitz H Van Heerden WF | 2003 | Am J Forensic Med Pathol2003，24，2： | 1 |
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