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| 1 | Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions显示文摘Objective: To evaluate the efficacy of oral indomethacin, ibuprofen, and paracetamol in oral dosage form on patent ductus arteriosus(PDA) in premature neonates with significant clinical and hemodynamic repercussions(CHRs) and to determine the effect of these respective treatments on renal function.Methods: A retrospective study of cases of PDA in premature neonates in the Neonatal Intensive Care Unit was conducted. The treatments consisted of indomethacin[0.2 mg/(kg$d), 3-day cycle], ibuprofen [10 mg/(kg$d) followed by 5 mg/(kg$d), 3-day cycle], and paracetamol(15 mg/kg every 6 h, 5-day cycle). The drugs were administered as an oral solution. The following variables were considered: gestational age,newborn weight at birth, Apgar score, diuresis, serum creatinine and urea levels, and serum electrolyte levels(sodium and potassium).Results: Treatment with indomethacin presented efficacy of 87.5% in closure of the ductus with a mean outcome period of 3.5 d. In premature neonates with CHRs and contraindications for indomethacin, the initial treatment with either ibuprofen or paracetamol failed to close the ductus. However, when this treatment was followed by indomethacin, closure occurred in 66.7% of the neonates, with an outcome period of9.66 d. The initial treatment with one cycle of ibuprofen followed by one or two cycles of paracetamol failed to close the ductus.Conclusions: Oral indomethacin was effective for closure of the PDA in premature neonates with severe CHRs. Oral paracetamol or ibuprofen for PDA closure in premature neonates with severe CHRs and contraindications for indomethacin was ineffective.However, results in clinical improvements of neonates allowed the subsequent use of indomethacin and successful closure of the ductus. A significant reduction of diuresis occurred in neonates who were treated with indomethacin, either as a first-line treatment or after the failure of ibuprofen or paracetamol. | Clarissa de Albuquerque Botura Bruno Ambrósio da Rocha Thiely Balensiefer Franciele Queiroz Ames Ciomar Aparecida Bersani-Amado Roberto Kenji Nakamura Cuman | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，11： | 4 |
| 2 | Diabetic neuropathy: An evaluation of the use of quercetin in the cecum of rats显示文摘AIM:To investigate the effect of quercetin supplementation on the myenteric neurons and glia in the cecum of diabetic rats.METHODS:Total preparations of the muscular tunic were prepared from the ceca of twenty-four rats divided into the following groups:control(C),control supplemented with quercetin(200 mg/kg quercetin body weight)(CQ),diabetic(D)and diabetic supplemented with quercetin(DQ).Immunohistochemical double staining technique was performed with HuC/D(general population)/nitric oxide synthase(nNOS),HuC-D/S-100and VIP.Density analysis of the general neuronal population HuC/D-IR,the nNOS-IR(nitrergic subpopulation)and the enteric glial cells(S-100)was performed,and the morphometry and the reduction in varicosity population(VIP-IR)in these populations were analyzed.RESULTS:Diabetes promoted a significant reduction(25%)in the neuronal density of the HuC/D-IR(general population)and the nNOS-IR(nitrergic subpopulation)compared with the C group.Diabetes also significantly increased the areas of neurons,glial cells and VIP-IR varicosities.Supplementation with quercetin in the DQ group prevented neuronal loss in the general population and increased its area(P<0.001)and the area of nitrergic subpopulation(P<0.001),when compared to C group.Quercetin induced a VIP-IR and glial cells areas(P<0.001)in DQ group when compared to C,CQ and D groups.CONCLUSION:In diabetes,quercetin exhibited a neuroprotective effect by maintaining the density of the general neuronal population but did not affect the density of the nNOS subpopulation. | Paulo Emilio Botura Ferreira Cláudia Regina Pinheiro Lopes Angela Maria Pereira Alves der Paulo Belato Alves David Robert Linden Jacqueline Nelisis Zanoni Nilza Cristina Buttow | 2013 | World Journal of Gastroenterology2013，19，38： | 2 |
| 3 | In vitro ovicidal and larvicidal activity of Agave sisalana Perr. (sisal) on gastrointestinal nematodes of goats显示文摘 | Mariana B. Botura Jener David G. dos Santos Gisele D. da Silva Hélimar G. de Lima Jo?o Victor A. de Oliveira Maria Angela O. de Almeida Maria José M. Batatinha Alexsandro Branco | 2013 | Veterinary Parasitology . 2013 (1-3)2013，，1： | 1 |
| 4 | An AI Tool for Supervising Substations显示文摘 | M S Ayala G J Botura O A Maldonado | 2001 | Potentials IEEE2001，20，5： | 1 |
| 5 | Piezoelectric transducer actuated leading edge de-icing with simultaneous shear and impulse forces显示文摘 | Venna S V Lin Y J Botura G | 2007 | Journal of Aircraft2007，44，2： | 1 |
| 6 | Determination of fungal microbiota and mycotoxins in brewers grain used in dairy cattle feeding in the State of Bahia,Brazil显示文摘 | Simas M M S Botura M B Correa B | 2007 | Food Control2007，18，5： | 1 |
| 7 | Virtual instrumentation: A practical approach to control and supervision process 显示文摘 | Lemos M A Brunini D M Botura G | 2011 | Computer Science and Network Technology (ICCSNT)2011，，： | 1 |
| 8 | Asystem for distributed sharing and reuse of design and manu-facturing knowledge in the PFMEA domain using a descrip-tion logics-based ontology显示文摘 | MIKOS W L FERREIRA J C E BOTURA P E A | 2011 | Journal of Manufacturing Sys-tems2011，30，3： | 1 |
| 9 | Piezoelectric transducer actuated leading edge de-icing with simultaneous shear and impulse forces显示文摘 | Venna S Lin Y Botura G | 2007 | Journal of Aircraft2007，44，2： | 1 |
| 10 | A system for distributed sharing and reuse of design and manufacturing knowledge in the PFMEA domain using a description logics-based ontology显示文摘 | MIKOS W L FERREIRA J C E BOTURA P E A | | 0，，03： | 1 |
| 11 | Determinationof fungal microbiota and mycotoxins in brewers grain usedin dairy cattle feeding in the State of Bahia,Brazil显示文摘 | Simas M M S Botura M B Correa B et a1 | 2007 | Food Control2007，18，5： | 1 |
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