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| 1 | Role of MGMT as biomarker in colorectal cancer显示文摘O6-methylguanine DNA methyltransferase(MGMT) gene promoter methylation plays an important role in colorectal carcinogenesis, occurring in about 30%-40% of metastatic colorectal cancer. Its prognostic role has not been defined yet, but loss of expression of MGMT, which is secondary to gene promoter methylation, results in an interesting high response to alkylating agents such as dacarbazine and temozolomide. In a phase 2 study on heavily pre-treated patients with MGMT methylated metastatic colorectal cancer, temozolomide achieved about 30% of disease control rate. Activating mutations of RAS or BRAF genes as well as mismatch repair deficiency may represent mechanisms of resistance to alkylating agents, but a dose-dense schedule of temozolomide may potentially restore sensitivity in RAS-mutant patients. Further development of temozolomide in MGMT methylated colorectal cancer includes investigation of synergic combinations with other agents such as fluoropyrimidines and research for additional biomarkers, in order to better define the role of temozolomide in the treatment of individual patients. | Alessandro Inno Giuseppe Fanetti Maria Di Bartolomeo Stefania Gori Claudia Maggi Massimo Cirillo Roberto Iacovelli Federico Nichetti Antonia Martinetti Filippo de Braud Ilaria Bossi Filippo Pietrantonio | 2014 | World Journal of Clinical Cases2014，2，12： | 10 |
| 2 | Clinical aspects and molecular basis of oxaliplatin neurotoxicity: Current management and development of preventive measures显示文摘 | Erick Gamelin Laurence Gamelin Laura Bossi Stefan Quasthoff | 2002 | Seminars in Oncology2002，，5： | 4 |
| 3 | Limit on the production of a light vector gauge boson in ? meson decays with the KLOE detector显示文摘 | D. Babusci D. Badoni I. Balwierz-Pytko G. Bencivenni C. Bini C. Bloise F. Bossi P. Branchini A. Budano L. Caldeira Balkest?hl G. Capon F. Ceradini P. Ciambrone E. Czerwiński E. Danè E. De Lucia G. De Robertis A. De Santis A. Di Domenico C. Di Donato R. Di | 2013 | Physics Letters B2013，，： | 4 |
| 4 | 程序升温汽化大体积进样气相色谱法同时测定空气中的甲醛及其他10种羰基污染物(英文)显示文摘Long-term indoor-air limit for formaldehyde stipulated by the European Commission is 1 μg/m3,while the World Health Organization has set a threshold of 100 μg/m3 that should not be exceeded for more than 30 min. To date,however,only a few analytical techniques have been developed that can be used to detect formaldehyde at these very restrictive limits. Thus,there is a need to develop for comprehensive methods for analyzing airborne formaldehyde and other carbonyl pollutants in the ambient environment. The aim of this study is to develop a highly sensitive online automated preconcentration gas chromatographic method using large-volume injection with a programmed temperature vaporization injector for the analysis of airborne formaldehyde and ten other carbonyl compounds. The influence of several parameters,such as the maximum volume injected,programmed temperature vaporization transfer time and temperature,carrier gas flow rate,and type of packing material was investigated. After optimization,highly satisfactory results in terms of the absolute and methodological detection limits were achieved,i. e. as low as the μg/m3 level for all the carbonyl pollutants studied. A commercially available sampler,originally designed for active sampling,was evaluated as a passive sampling device;this optimized technique was applied to monitor the concentrations of carbonyl pollutants in the indoor air of ten public buildings in Florence. The strength of this methodology lies both in the low detection limits reached in the simultaneous analysis of a wide group of 2,4-dinitrophenylhydrazine derivatives,and the potential adaptability of this method to other gas chromatographic applications to achieve lower sensitivity. | Stefano DUGHERI Nicola MUCCI Ilenia POMPILIO Giovanni CAPPELLI Costanza BOSSI AlessANDro BONARI Giulio ARCANGELI | 2018 | 色谱2018，36，12： | 3 |
| 5 | Search for light vector boson production in e + e ? → μ + μ ? γ interactions with the KLOE experiment显示文摘 | D. Babusci I. Balwierz-Pytko G. Bencivenni C. Bloise F. Bossi P. Branchini A. Budano L. Caldeira Balkest?hl F. Ceradini P. Ciambrone F. Curciarello E. Czerwiński E. Danè V. De Leo E. De Lucia G. De Robertis A. De Santis P. De Simone A. Di Cicco A. Di Dome | 2014 | Physics Letters B2014，，： | 3 |
| 6 | Levels and trends of poly-and perfluoroalkyl substances in the Arctic environment-An update显示文摘Poly-and perfluoroalkyl substances(PFASs)are important environmental contaminants globally and in the early 2000s they were shown to be ubiquitous contaminants in Arctic wildlife.Previous reviews by Butt et al.and Letcher et al.have covered studies on levels and trends of PFASs in the Arctic that were available to 2009.The purpose of this review is to focus on more recent work,generally published between 2009 and 2018,with emphasis on PFASs of emerging concern such as perfluoroalkyl carboxylates(PFCAs)and short-chain perfluoroalkyl sulfonates(PFSAs)and their precursors.Atmospheric measurements over the period 2006e2014 have shown that fluorotelomer alcohols(FTOHs)as well as perfluorobutanoic acid(PFBA)and perfluoroctanoic acid(PFOA)are the most prominent PFASs in the arctic atmosphere,all with increasing concentrations at Alert although PFOA concentrations declined at the Zeppelin Station(Svalbard).Results from ice cores show generally increasing deposition of PFCAs on the Devon Ice cap in the Canadian arctic while declining fluxes were found in a glacier on Svalbard.An extensive dataset exists for long-term trends of long-chain PFCAs that have been reported in Arctic biota with some datasets including archived samples from the 1970s and 1980s.Trends in PFCAs over time vary among the same species across the North American Arctic,East and West Greenland,and Svalbard.Most long term time series show a decline from higher concentrations in the early 2000s.However there have been recent(post 2010)increasing trends of PFCAs in ringed seals in the Canadian Arctic,East Greenland polar bears and in arctic foxes in Svalbard.Annual biological sampling is helping to determine these relatively short term changes.Rising levels of some PFCAs have been explained by continued emissions of long-chain PFCAs and/or their precursors and inflows to the Arctic Ocean,especially from the North Atlantic.While the effectiveness of biological sampling for temporal trends in long-chain PFCAs and PFSAs has been demonstrated,this does not apply to the C4eC8ePFCAs,perfluorobutane sulfonamide(FBSA),or perfluorobutane sulfonate(PFBS)which are generally present at low concentrations in biota.In addition to air sampling,sampling abiotic media such as glacial cores,and annual sampling of lake waters and seawater would appear to be the best approaches for investigating trends in the less bioaccumulative PFASs. | Derek Muir Rossana Bossi Pernilla Carlsson Marlene Evans Amila De Silva Crispin Halsall Cassandra Rauert Dorte Herzke Hayley Hung Robert Letcher Frank Riget Anna Roos | 2019 | Emerging Contaminants2019，5，1： | 3 |
| 7 | Liver fibrosis and tissue architectural change measurement using fractal-rectified metrics and Hurst's exponent显示文摘瞄准:提供在最新形成的骨胶原的颠倒上监视新抗病毒的药的效果的精确其他的韵律的工具。方法:与纤维变性或肝硬化的不同等级与长期的 C 病毒性肝炎从 209 个病人拿的数字化的组织学的活体检视节,基于用分数维的原则修正的国际系统米借助于一个新、快速的、用户友好的、充分电脑辅助的方法被测量。结果:下列被描述:几何周界,区域和纤维变性的起皱的海角;Knodell, Sheuer, Ishak 和 METAVIR 的核对与修正分数维图形的公制的大小得分;在与骨胶原小岛的大小的关系的纤维变性的物理作文的意思;intra 活体检视和这些参数的内部活体检视的样品可变性;显示小径的活体检视节的“阶段”向它的最大的已知的价值由纤维变性形成盖住;量的肝织物有林中小丘代表的建筑上的变化。结论:我们的模型提供纤维变性的几何性质和肝织物的量的建筑上的变化的第一韵律的评估。整个肝的组织学的节的代表性的海角也根据与林中小丘系数获得的结果被讨论。 | Nicola Dioguardi Fabio Grizzi Barbara Franceschini Paola Bossi Carlo Russo | 2006 | World Journal of Gastroenterology2006，12，14： | 2 |
| 8 | An uncommon cause of corrosive esophageal injury显示文摘We present an unusual case of corrosive esophageal injury following liquid glue ingestion. The endoscopic f indings were tissue sloughing and blackened appearance of the esophagogastric junction,due to caustic esophageal injuries following ingestion of glue containing toluene. | Fabio Pace Salvatore Greco Stefano Pallotta Daniela Bossi Emilio Trabucchi Gabrielle Bianchi Porro | 2008 | World Journal of Gastroenterology2008，14，4： | 2 |
| 9 | Non-synaptic mechanisms underlie the after-effects of cathodal transcutaneous direct current stimulation of the human brain显示文摘 | Ardolino G Bossi B Barbieri S | 2005 | J Physiol2005，568，2： | 1 |
| 10 | Mitochondrial cytochrome release in apoptosis occurs upstream of DEVD -specfic caspase activation and independently of mitochondrial transmembrane depolarization 显示文摘 | Bossy Wetzel E Neweoeyer DD Green DR | 1998 | EMBO J1998，17，： | 1 |
| 11 | Clinical aspects and molecular basis of oxaliplatin neurotoxicity: current management and development of preventive measures 显示文摘 | GAMELIN E GAMELIN L BOSSI L | 2002 | Semin Oncol2002，29，515： | 1 |
| 12 | Severe pelvic injuries: indications and techniques of skeletal fixation 显示文摘 | Garbuglia A Bossi E Ronzani C | 1998 | Chit Ital1998，50，6： | 1 |
| 13 | Fusion of conven- tional ultrasound imaging and acousto-optic sensing by use of a standard pulsed-ultrasound scanner 显示文摘 | BOSSY E SUI L MURRAY T W | 2005 | Opt Lett2005，30，7： | 1 |
| 14 | Novel Munc13-4mutations in children and young adult patients withhaemophagocytic lymphohistiocytosis显示文摘 | Santoro A Cannella S Bossi G | 2006 | J Med Genet2006，43，12： | 1 |
| 15 | Serum matrix met- alloproteinase - 9: tissue inhibitor of metalloproteinase - I ratio correlates with steroid responsiveness in moderate to severe asthma显示文摘 | BOSSI M CHAKIR J ROUABHIA M | 1999 | Am J Respir Crit Care Med1999，159，2： | 1 |
| 16 | Cloning of an avian adeno-assoeoated virus (AAAV) and generation of recombinant AAAV particles 显示文摘 | Bossis I Chiorini J A | 2003 | J Virol2003，77，12： | 1 |
| 17 | Paliperidone extendedrelease tablet s in schizophrenia patients previously treated with risperidone 显示文摘 | CANUSO C M YOUSSEF E A BOSSIE C A | 2008 | Int Clin Psychopharmacol2008，23，4： | 1 |
| 18 | Interleukin-18, from nan- roinflammafion to Alzheimer's disease显示文摘 | Bossi P Ciaramella A Salani F | 2010 | Curt Pharm Des2010，16，38： | 1 |
| 19 | Two-dimensional electrophoresis of proteins discriminates aphid clones of Sitobion avenae differing in BYDV-PAV transmission显示文摘 | Papura D Jacquot E Dedryver C A Luche S Riault G Bossis M Rabilloud T | | 0，，： | 1 |
| 20 | Novel Munc 13-4 mutations in children and young adult patients with haemophagocytic lym- phohistiocytosis 显示文摘 | Santoro A Cannella S Bossi G | 2006 | J Med Genet2006，43，12： | 1 |
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