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| 1 | Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated. | Andreas Weber Sonja Landrock Jochen Schneider Manfred Stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz | 2007 | World Journal of Gastroenterology2007，13，9： | 23 |
| 2 | Sieving characteristics of cytokine-and peroxide-induced epithelial barrier leak:Inhibition by berberine显示文摘AIM:To study whether the inflammatory bowel disease(IBD)colon which exhibits varying severity and cytokine levels across its mucosa create varying types of transepithelial leak.METHODS:We examined the effects of tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-1-β(IL1β)and hydrogen peroxide(H_2O_2)-singly and in combinations-on barrier function of CACO-2 cell layers.Our focus was on the type(not simply the magnitude)of transepithelial leak generated by these agents as measured by transepithelial electrical resistance(TER)and transepithelial flux of ^(14)C-D-mannitol,3H-Lactulose and ^(14)C-Polyethylene glycol as radiolabeled probe molecules.The isoquinoline alkaloid,berberine,was then examined for its ability to reduce specific types of transepithelial leak.RESULTS:Exposure to TNF-α alone(200 ng/mL;48 h)induced a 50% decrease in TER,i.e.,increased leak of Na^+ and Cl--with only a marginal but statistically significant increase in transepithelial leak of ^(14)C-mannitol(Jm).Exposure to TNF-α + IFN-γ(200 ng/mL;48 h)+ IL1β(50 ng/mL;48 h)did not increase the TER change(from TNF-α alone),but there was now a 100% increase in J_m.There however was no increase in transepithelial leak of two larger probe molecules,~3H-lactulose and ^(14)C-polyethylene glycol(PEG).However,exposure to TNF-α + IFN-γ + IL1β followed by a 5 h exposure to2 mmol/L H_2O_2 resulted in a 500% increase in ^(14)C-PEG leak as well as leak to the luminal mitogen,epidermal growth factor.CONCLUSION:This model of graded transepithelial leak is useful in evaluating therapeutic agents reducing IBD morbidity by reducing barrier leak to various luminal substances. | Katherine M DiGuilio Christina M Mercogliano Jillian Born Brendan Ferraro Julie To Brittany Mixson Allison Smith Mary Carmen Valenzano James M Mullin | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 6 |
| 3 | Diversity of yO T-cell antigens显示文摘 | Willi K Born M Kemal Aydintug Rebecca L O'Brien | 2013 | Cellular & Molecular Immunology2013，10，1： | 2 |
| 4 | Control of Fusarium wilt of radish by combining Pseudomonas putida strains that have different disease-suppressive mechanisms显示文摘 | de Boer M Born P Kindt F | 2003 | Phytopathology2003，93，5： | 1 |
| 5 | The parallel genetic algorithm as function optimizer 显示文摘 | Schomish M Born J | 1991 | Parallel Computing1991，17，： | 1 |
| 6 | Cigarette smoking increases sympathetic outflow in humans 显示文摘 | Narkiewiez K Borne PJHvd Hausberg M | 1998 | Circulation1998，98，6： | 1 |
| 7 | A construct-driven investigation of gender differences in a leadership-role assessment center显示文摘 | Anderson N Lievens F van Dam K Born M | | 0，，： | 1 |
| 8 | The parallel genetic al-gorithm as function optimizer显示文摘 | MHLENBEIN H SCHOMISCH M BORN J | 1991 | Parallel Computing1991，17，67： | 1 |
| 9 | Intentional response distortion on personality tests: using eye-tracking tounderstand response processes when faking显示文摘 | Van Hooft E A Born M P | 2012 | Journal of Applied Psychology2012，97，2： | 1 |
| 10 | Functional magnetic resonance imaging of the normal and abnormal visual system in early life显示文摘 | BORN A P MIRANDA M J ROSTRUP E | 2000 | Neuropediatrics2000，31，： | 1 |
| 11 | The parallel genetic algorithm as function optimizer显示文摘 | Muhlenbein H Schomisch M Born J | 1991 | Parallel Computing1991，17，： | 1 |
| 12 | Psychosocial adaptation to stoma surgery:a review显示文摘 | Bekkers M Van Knippenberg F C E Van Den Borne H W | 1995 | Journal of Behavioral Medicine1995，18，1： | 1 |
| 13 | Hemiconvulsion-hemiplegia-epi- lepsy syndrome as a presenting feature of L-2-hydroxyglutaric acidur- ia显示文摘 | Lee C Born M Salomons GS | 2006 | J Child Neurol2006，21，6： | 1 |
| 14 | Reduced hippocampal glutamate in Alzheimer disease显示文摘 | Rupsingh R Borne M Smith M | 2009 | Neurobiol Aging2009，32，： | 1 |
| 15 | Zur Quantentheorie der Mole- keln显示文摘 | BORN M OPPENHEIMER R | 1927 | Annalen Der Physik1927，，20： | 1 |
| 16 | On the stability of crystal lattices 显示文摘 | Born M | 1940 | Proc Cambridge PhilosSoc1940，36，： | 1 |
| 17 | Psychosocial adaptation to stoma surgery: a review显示文摘 | BEKKERS M J VAN KNIPPENBERG F C VAN DEN BORNE H W | 1995 | J Behav Med1995，18，1： | 1 |
| 18 | Irritability:the forgotten dimension of female-specific mood disorders显示文摘 | Born L Steiner M | 1999 | Arch Women Ment Health1999，2，4： | 1 |
| 19 | Multivariate deformation-based analysis of brain atrophy to predict Alzheimer's disease in mild cognitive impairment显示文摘 | Teipel SJ Born C Ewers M | 2007 | Neuroimage2007，38，1： | 1 |
| 20 | Concentric and eccentric assessment of flexor-extensor torque ratios at the hip, knee, and ankle in a sample population of healthy subjects显示文摘 | Calmes PM Nellen M van der Borne | 1997 | Arch Phys Med Rehabil1997，78，： | 1 |
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