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| 1 | 生物素——抗结核药物新研究方向(英文)显示文摘耐药菌的出现对全球公共卫生构成了巨大的挑战,结核分枝杆菌(TB)是结核病的病原菌,是临床上最重要的病原体之一。新抗生素的研发用以治疗耐药性结核病已成为临床及公共卫生管理亟待解决的重要问题。生物素(维生素B7)在结核杆菌的代谢途径如脂肪酸合成和三羧酸循环中发挥重要作用,通过生物素蛋白连接酶连接活性辅助因子而被激活。生物素蛋白连接酶及其相关生物合成通路是微生物合成生物素过程中必不可或缺的关键分子,因而有可能成为新的药物靶点。遗传研究表明,结核杆菌需要由菌体进行生物素的全程合成,因此,生物素合成酶在在结核杆菌代谢过程中起着至关重要的作用,引起了抗结核药物研究者的高度重视。本文论述了结核杆菌生物素合成通路,并重点分析了生物素合成过程中可能成为药物靶点的关键酶,旨在为结核病的治疗提供新思路,具有重要的临床意义。 | THOMPSON Andrew P STERNICKI Louise M WEGENER Kate L 陆伟 竺丽梅 BOOKER Grant W POLYAK Steven W 李燕 | 2016 | 江苏预防医学2016，27，3： | 4 |
| 2 | Arbuscular mycorrhizal fungi increase organic carbon decomposition under elevated CO2显示文摘 | Cheng L Booker FL Tu C Burkey KO Zhou LS Shew HD Rufty TW Hu SJ | | 0，，： | 1 |
| 3 | Comparison of 2 methods of managing gastric residual volumes from feeding tubes显示文摘 | Booker K J Niedringhaus L | 2000 | Am J Crit Care2000，9，5： | 1 |
| 4 | Classifier Systems and Genetic Algorithms显示文摘 | Booker L B Goldberg D E Holland J H | 1989 | Artificial Intelligence1989，40，： | 1 |
| 5 | The role of ozone flux and antioxidants in the suppression of ozone injury by elevated CO2 in soybean显示文摘 | Booker F L Fiscus E L | 2005 | Journal of Experimental Botany2005，56，418： | 1 |
| 6 | Ammonia Remov-al From Sewage Using Natural Australian Zeolite显示文摘 | BOOKER N A COONEY E L PRIESTLEY A J | 1996 | Water Sci-ence & Technology1996，34，9： | 1 |
| 7 | Classifier systems and genetic algorithms显示文摘 | GOLDBERG D E AND HOLLAND J F | 1989 | Elsevier Science Publishers Ltd1989，40，13： | 1 |
| 8 | Ammonia removal from sewage using natural Australian zeolite 显示文摘 | Booker N A Cooney E L Priestly A J | 1996 | Water Sci Technol1996，34，： | 1 |
| 9 | Molecular interactions of the IGF system 显示文摘 | Denley A Cosgrove L J Booker G W | 2005 | Cytokine Growth Factor Rev2005，16，： | 1 |
| 10 | Classififier Systems and Genetic Algorithms显示文摘 | Booker Goldberg L B Holland J H | 1989 | Artificial Intelligence1989，，40： | 1 |
| 11 | Classfier Systems and Genetic Algorithms 显示文摘 | Booker L B Goldberg D E Holland J H | 1989 | Artifical Intelligence1989，40，1： | 1 |
| 12 | Altered functional properties of tritordeum by transformation with glutenin subunit genes 显示文摘 | Booker L Barro F Tatham A S | 1999 | Thero Appl Genet1999，99，： | 1 |
| 13 | Ammonia removal from sewage using natural Australian zeolite显示文摘 | Booker N A Cooney E L Priestley A J | | 0，，09： | 1 |
| 14 | A seientometric analysis of knowledge management and intellectual capital academic literature (1994-2008)显示文摘 | Serenko A Bontis N Booker L | 2010 | Journal of knowledge management2010，14，1： | 1 |
| 15 | Electrically Conductive Crust in Southern Tibet from INDEPTH Magnetotelluric Surveying显示文摘 | Chen L Booker J R Jones A G | 1996 | Science1996，274，： | 1 |
| 16 | Structure-activity relationships of phosphoinositide 3-kinase(PI3K)/mammalian target of rapamycin(m TOR)dual inhibitors:investigations of various 6,5-heterocycles to improve metabolic stability显示文摘 | STEC M M ANDREWS K L BOOKER S K | 2011 | J Med Chem2011，54，14： | 1 |
| 17 | Comparative responses of container versus ground-grown soybean to elevated carbon dioxide and ozone显示文摘 | Booker F L Miller J E Fiscus E L | 2005 | Crop Science2005，45，3： | 1 |
| 18 | Atmospheric carbon dioxide, irrigation, and fertilization effects on phenolic and nitrogen concentrations in loblolly pine (Pinus taeda) needles显示文摘 | BOOKER F L MAIER C A | 2001 | Tree Physiology2001，21，： | 1 |
| 19 | Classifier systems and genetic algorithms显示文摘 | BOOKER L B GOLDBERG D E HOLLAND J H | 1989 | Artif Intell1989，40，： | 1 |
| 20 | Investigation on the Response of Segmented Concrete Targets to Projectile Impacts 显示文摘 | Booker P M Cargile J D Kistler B L | 2009 | International Journal of Impact Engineering2009，，36： | 1 |
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