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| 1 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 2 | GSTM3, but not IZUMO1, is a cryotolerance marker of boar sperm显示文摘Background: Cryopreservation is currently the most efficient method for long-term preservation of mammalian gametes and is extensively used in swine artificial insemination(AI) centres. However, it is well-known that cryopreservation procedures induce changes in the water phase in both intra and extracellular compartments,which alter the content and localisation of several proteins and ends up curtailing the structural integrity of functional sperm(i.e., cryoinjuries). Alterations and deficiencies of sperm-oocyte binding proteins during gamete recognition are one of the causes of reproductive failure both in vitro and in vivo. In this sense, characterisation of cryopreservation effects upon oocyte-binding proteins of sperm, such as IZUMO1 and GSTM3, is essential when assessing the impact of this technique in swine reproduction.Results: Cryopreservation was found to induce changes in the localisation of IZUMO1 and GSTM3 in boar sperm.However, the relative content of both proteins was not altered after thawing. Furthermore, whereas IZUMO1 content was found not to be related to the cryotolerance of boar sperm, GSTM3 content was observed to be higher in poor(PFE) than in good(GFE) freezability ejaculates in both pre-frozen(1.00 INT·mm^2± 0.14 INT·mm^2 vs.0.72 INT·mm^2± 0.15 INT·mm^2;P < 0.05) and post-thawed(0.96 INT·mm^2± 0.20 INT·mm^2 vs. 70 INT·mm^2± 0.19 INT·mm^2;P < 0.05) samples. Moreover, GSTM3 levels were found to be higher in those spermatozoa that exhibited low mitochondrial activity, high reactive oxygen species(ROS) production, and high membrane lipid disorder postthaw(P < 0.05).Conclusions: The difference in GSTM3 content between GFE and PFE, together with this protein having been found to be related to poor sperm quality post-thaw, suggests that it could be used as a cryotolerance marker of boar spermatozoa. Furthermore, both IZUMO1 and GSTM3 relocate during cryopreservation, which could contribute to the reduced fertilising capacity of frozen-thawed boar sperm. | Marc Llavanera Ariadna Delgado-Bermúdez Beatriz Fernandez-Fuertes Sandra Recuero Yentel Mateo Sergi Bonet Isabel Barranco Marc Yeste | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 4 |
| 3 | Anemia in patients with high-risk acute coronary syndromes admitted to Intensive Cardiac Care Units显示文摘Background Little information exists about the role of anemia in patients with acute coronary syndromes(ACS)admitted to Intensive Cardiac Care Units(ICCU).The aim of this study was to assess the prevalence of anemia and its impact on management and outcomes in this clinical setting.Methods All consecutive patients admitted to eight different ICCUs with diagnosis of non-ST segment elevation ACS(NSTEACS)were prospectively included.Anemia was defined as hemoglobin<130 g/L in men and<120 g/L in women.The association between anemia and mortality or readmission at six months was assessed by the Cox regression method.Results A total of 629 patients were included.Mean age was 66.6 years.A total of 197 patients(31.3%)had anemia.Coronary angiography was performed in most patients(96.2%).Patients with anemia were significantly older,with a higher prevalence of comorbidities,poorer left ventricle ejection fraction and higher GRACE score values.Patients with anemia underwent less often coronary angiography,but underwent more often intraaortic counterpulsation,non-invasive mechanical ventilation and renal replacement therapies.Both ICCU and hospital stay were significantly longer in patients with anemia.Both the incidence of mortality(HR=3.36,95%CI:1.43–7.85,P=0.001)and the incidence of mortality/readmission were significantly higher in patients with anemia(HR=2.80,95%CI:2.03–3.86,P=0.001).After adjusting for confounders,the association between anemia and mortality/readmission remained significant(P=0.031).Conclusions Almost one of three NSTEACS patients admitted to ICCU had anemia.Most patients underwent coronary angiography.Anemia was independently associated to poorer outcomes at 6 months. | Victoria Lorente Jaime Aboal Cosme Garcia Jordi Sans-Rosello Antonia Sambola Rut Andrea Carlos Tomas Gil Bonet David Vinas Nabil el Ouaddi Santiago Montero Javier Cantalapiedra Margarida Pujol Isabel Hernandez Maria Perez-Rodriguez Isaac Llao Jose C Sanchez-Salado Miquel Gual Albert Ariza-Sole 无 | 2020 | Journal of Geriatric Cardiology2020，17，1： | 2 |
| 4 | An alternating digital tree (ADT) algorithm for 3D geometric searching and inter-section problems显示文摘 | Bonet J Peraire J | 1991 | International Journal for Numerical Methods in Engineering1991，31，1： | 1 |
| 5 | An alternating digital tree (ADT) algorithm for 3D geometric searching and intersection problems显示文摘 | BONET J | 1991 | International Journal for Numerical Methods in Engineering1991，31，： | 1 |
| 6 | Secondary succession of semi-arid mediterranean old-fields in south eastern spain:insights for conservation and restoration of degraded lands显示文摘 | BONET A | 2004 | Journal of Arid Environments2004，56，2： | 1 |
| 7 | The endothelia cell protein C receptor:Its role in thrombosis显示文摘 | Navarro S Bonet E Estelles A | 2011 | Thromb Res2011，128，5： | 1 |
| 8 | Food safety and functional foods in the European Union:Obesity as a paradigmatic example for novel food development显示文摘 | PALOU A PICO C BONET M L | 2004 | Nutrition Reviews2004，62，7： | 1 |
| 9 | High pressure die casting simulation using a lagrangian particle method显示文摘 | Kulasegaram S Bonet J Lewis J | 2003 | Communication in Numerical Methods in Engineering2003，19，9： | 1 |
| 10 | Mesh adaptive computation of upper and lower bounds in limit analysis显示文摘 | CIRIA H PERAIRE J BONET J | 2008 | ternational Journal for Numerical Methods in Engineering2008，75，8： | 1 |
| 11 | Correction and stabilization of smooth particle hydrodynamics methods with applications in metal forming simulations显示文摘 | BONET J KULASEGARAM S | 2000 | International Journal of Numerical Methods in Engineering2000，47，： | 1 |
| 12 | Discontinuous Galerkin solution of the Navier-Stokes equations on de- formable domains显示文摘 | PERSSON P O BONET J PERAIRE J | 2009 | Computer Methods in Applied Me- chanics and Engineering2009，198，17： | 1 |
| 13 | FT-IR investigation on char formation during the early stages of coal pyrolysis显示文摘 | IBARRA J V MILINER R BONET A J | 1994 | Fuel1994，73，6： | 1 |
| 14 | Effect of microbial transglutaminase on the rbeological and thermal properties of insect damaged wheat flour 显示文摘 | Caballero P A Bonet A Rosell C M Gomez M | 2005 | Journal of Cereal Science2005，42，1： | 1 |
| 15 | Upper and lower bounds in limit analysis: Adaptive meshing strategies and discontinuous loading显示文摘 | MUNOZ J J BONET J HUERTA A | 2009 | International Journal for Numerical Methods in Engineering2009，77，4： | 1 |
| 16 | FIR investigation on char formation during the early stages of coal pyrolysis 显示文摘 | Ibarra J V Moliner R Bonet A | 1994 | Fuel1994，73，6： | 1 |
| 17 | Lead electrowinning in a fluoborate medium. Use of hydrogen diffusion anodes显示文摘 | E Expósito J González-Garc??a P Bonete V Montiel A Aldaz | 2000 | Journal of Power Sources2000，，1： | 1 |
| 18 | An alternating digital tree (ADT) algorithm for 3D geometric searching and intersection problems显示文摘 | Bonet J Peraire J | 1991 | International Journal for Numerical Methods in Engineering1991，31，1： | 1 |
| 19 | Characterization of the behavior of flavour microcapsules in cotton fabrics 显示文摘 | MONLLOR P BONET M A CASES F | 2007 | European Polymer Journal2007，43，6： | 1 |
| 20 | Effects of 30-yearold Aleppo pine plantations on runoff,soil erosion,and plant diversity in a semi-arid landscape in south eastern Spain 显示文摘 | Chirino E Bonet A Bellot J Sa′nchez JR | 2006 | Catena2006，65，： | 1 |
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