|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antidepressant-Like Effects of Hesperidin in Animal Model of Post-Traumatic Stress Disorder显示文摘Objective:Post-traumatic stress disorder(PTSD)is a psychiatric disorder characterized by depression and anxiety,that arises due to an imbalance of neurotransmitters in response to excessive stress.Hesperidin(HSD)is a naturally occurring flavonoid shown to exert a variety of biological activities,including antioxidant,anti-inflammatory,and neuroprotective effects.Methods:This study was used the open field test(OFT)and forced swimming test(FST)to examine the effects of HSD on the depression-like response of rats after exposure to a single prolonged stress(SPS)leading to the dysregulation of the serotonergic activation system.Male rats were given HSD(20,50,and 100 mg/kg,intraperitoneal injection,n=6–7 per group)once daily for 14 days after exposure to SPS.The influence of administration of HSD on SPS-induced behavioral responses and concentrations of serotonin(5-HT),5-hydroxyindoleacetic acid(5-HIAA),and monoamine oxidase-A(MAO-A)in the rat brain were also investigated using enzyme-linked immunoassays(ELISAs).Results:Daily HSD administration significantly improved depression-like behaviors in the FST(P<0.05),increased the number of lines crossed in the central zone of the OFT(P<0.01),and reduced freezing behavior both in contextual and cued fear conditioning.HSD treatment also attenuated the reduction in SPS-induced 5-HT concentrations in the hippocampus and amygdala.This increase in 5-HT concentrations during HSD treatment was partially attributed to a decrease in the 5-HIAA/5-HT ratio in the hippocampus of rats with PTSD.Furthermore,HSD treatment inhibited activity of MAO-A and decreases of tryptophan hydroxylase-1 expression in the hippocampus.Conclusion:HSD was shown to exert antidepressant effects in rats exposed to SPS,suggesting that this natural flavonoid may be an effective medicine for PTSD. | Bombi Lee Gwang Muk Choi Bongjun Sur | 2021 | Chinese Journal of Integrative Medicine2021，27，1： | 4 |
| 2 | How low does ethical leadership flow? Test of a trickle-down model显示文摘 | David M. Mayer Maribeth Kuenzi Rebecca Greenbaum Mary Bardes Rommel (Bombie) Salvador | 2008 | Organizational Behavior and Human Decision Processes2008，，1： | 2 |
| 3 | Pathology of bone marrow transplantation显示文摘 | Bombi JA Palou J Bruguera M | 1992 | Semin Diagn Pathol1992，9，3： | 1 |
| 4 | Myoepithelial tumors of salivary glands:a clincopathologic,immunohistochemical,ultrastructural,and flow-cytometric study显示文摘 | Alos L Cardesa A Bombi JA | 1996 | Semin Pathol1996，13，： | 1 |
| 5 | Myoepithelial carcinoma arising in a benign myoepithelioma : immunohistochemical, uhrastructural, andflow-cytometrical study 显示文摘 | Bombi JA Alos L Rey MJ | 1996 | Uhrastruct Pathol1996，20，2： | 1 |
| 6 | Ultrastructurai and molecular heterogeneity in non-small cell lung carcinomas:study of 110 cases and review of the literature显示文摘 | BOMBI J A MARTINEZ A RAMIREZ J | 2002 | Ultrastruct Pathol2002，26，： | 1 |
| 7 | Gastric mucosal vascular ectasias causing bleeding in cirrhosis: a distinct entity associated with hypergastrenemia and low serum levels of pepsinogen显示文摘 | Quintero E Pique J M Bombi J A | 1987 | Gastroenterology1987，83，7： | 1 |
| 8 | Gastric mucosal vascular ectasias causingbleeding in cirrhosis:a distinct entity associated with hypergastrenemia and low serumlevels of pepsinogen 1显示文摘 | Quintero E Pique JM Bombi JA | 1987 | Gastroenterology1987，83，7： | 1 |
| 9 | Adsorbate-induced surface stress and self-assembly of (2 × 1) O on Cu(110) measured with an STM显示文摘 | Bombis Ch Moiseeva M Ibach H | 2005 | Phys Rev B2005，72，24： | 1 |
| 10 | Myoepithelial tumors of salivary glands:a clinicopathologic,immunohistochemical,ultrastructural and flow-cytometric study显示文摘 | Alos L Cardesa A Bombi J A | 1996 | Semin Diagn Pathol1996，13，2： | 1 |
| 11 | Myoepithelial tumors of salivary glands : a clinicopathologic, immunohistochemical, uhrastructural and flow-cytometric study 显示文摘 | Alos L Cardesa A Bombi JA | 1996 | Semin Diagn Pathol1996，13，2： | 1 |
| 12 | Myoep ithelial tumors of salivary glands:a clincopathologic,immunohistochemical,ultrastructural,and flow-cytometric study显示文摘 | ALOS L CARDESA A BOMBI J A | 1996 | Semin Pathol1996，13，： | 1 |
| 13 | Aluminium toxicity and metal speciation:established data and open questions显示文摘 | Corain B Bombi GG Tapparo A Perazzolo M Zatta P | 1996 | Coord Chem Rev1996，149，2： | 1 |
| 14 | Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear显示文摘 | Mijung Yeom Sung-Hun Kim Bombi Lee Jeong-Jun Han Guk Hoon Chung Hee-Don Choi Hyejung Lee Dae-Hyun Hahm | 2012 | Journal of Dermatological Science2012，，2： | 1 |
| 15 | Myoeplthelial tumors of salivary glands: a clinicopathologic, ultrastructural and flow-cytometric study显示文摘 | Alos L Cardesa A Bombi JA | 1996 | Serum Diagn Pathol1996，13，2： | 1 |
| 16 | Nuclease-resistant sin- gle-stranded DNA controls for nucleic acid amplification assays 显示文摘 | Gotsch A Schubert A Bombis A | 2007 | J Clin Microbiol2007，45，8： | 1 |
| 17 | Inhibitory Effects of Coptidis rhizoma and Berberine on Cocaine-induced Sensitization显示文摘 | Bombi Lee Chae Ha Yang Dae-Hyun Hahm | 2007 | eCAM2007，1093，： | 1 |
| 18 | Neuro-protective effect of palmul-chongmyeong-tang on ische-mia-induced learning and memory deficits in the rat显示文摘 | YOUNG-JU Y BOMBI L DAE-HYUN H | 2007 | Biol Pharm Bull2007，30，2： | 1 |
| 19 | Developmental trajectories of physical aggression:pre-diction of overt and covert antisocial behaviors from self-and mothers’reports显示文摘 | Di Giunta L Pastorlli C Eisenberg N Gerbino M Castellani V Bombi A S | 2010 | Eur Child Adolesc Psychiatry2010，19，： | 1 |
| 20 | Experimental aluminum pathology in rabbits: Effects of hydrophilic and lipophilic compounds 显示文摘 | BOMBI GG CORAIN B FAVARATO M | 1990 | Environ Health Perspect1990，89，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员