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| 1 | Reservoir-induced landslides and risk control in Three Gorges Project on Yangtze River,China显示文摘The Three Gorges region in China was basically a geohazard-prone area prior to construction of the Three Gorges Reservoir(TGR).After construction of the TGR,the water level was raised from 70 m to 175 m above sea level(ASL).and annual reservoir regulation has caused a 30-m water level difference after impoundment of the TGR since September 2008.This paper first presents the spatiotemporal distribution of landslides in six periods of 175 m ASL trial impoundments from 2008 to 2014.The results show that the number of landslides sharply decreased from 273 at the initial stage to less than ten at the second stage of impoundment.Based on this,the reservoir-induced landslides in the TGR region can be roughly classified into five failure patterns,i.e.accumulation landslide,dip-slope landslide,reversed bedding landslide,rockfall,and karst breccia landslide.The accumulation landslides and dip-slope landslides account for more than 90%.Taking the Shuping accumulation landslide(a sliding mass volume of 20.7 × 10~6 m^3) in Zigui County and the Outang dip-slope landslide(a sliding mass volume of about 90 × 10~6 m^3) in Fengjie County as two typical cases,the mechanisms of reactivation of the two landslides are analyzed.The monitoring data and factor of safety(FOS) calculation show that the accumulation landslide is dominated by water level variation in the reservoir as most part of the mass body is under 175 m ASL,and the dip-slope landslide is controlled by the coupling effect of reservoir water level variation and precipitation as an extensive recharge area of rainfall from the rear and the front mass is below 175 m ASL.The characteristics of landslide-induced impulsive wave hazards after and before reservoir impoundment are studied,and the probability of occurrence of a landslide-induced impulsive wave hazard has increased in the reservoir region.Simulation results of the Ganjingzi landslide in Wushan County indicate the strong relationship between landslide-induced surge and water variation with high potential risk to shipping and residential areas.Regarding reservoir regulation in TGR when using a single index,i.e.1-d water level variation,water resources are not well utilized,and there is also potential risk of disasters since 2008.In addition,various indices such as 1-d.5-d,and 10-d water level variations are proposed for reservoir regulation.Finally,taking reservoir-induced landslides in June2015 for example,the feasibility of the optimizing indices of water level variations is verified. | Yueping Yin Bolin Huang Wenpei Wang Yunjie Wei Xiaohan Ma Fei Ma Changjun Zhao | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，5： | 45 |
| 2 | Coesite inclusions in zircon from gneisses identified by laser Raman microspectrometer in ultra-high pressure zone of Dabie Mountains,China显示文摘The mineral inclusions in zircon from gneisses in ultra-high pressure (UHP) zone of the Dabie Mountains were identified by using a laser Raman microspectrometer. Coesite occurs as inclusions in zircons from all types of gneiss. Other important minerals, such as jadeite, omphacite, aragonite, barite, and anhydrite were also found as inclusion minerals. These discoveries indicate that ( i) gneissic country rocks had metamorphosed at the same time as the enclosed eclogites; and (ii) SO4-2 -bearing fluids were presentin the UHP metamorphic process, which is manifested by occurrence of barite and anhydrite coexisting with coesite. | LIU Jingbo YE Kai CONG Bolin Maruyama Shegnori FAN Hongrui | 2001 | Chinese Science Bulletin2001，46，22： | 22 |
| 3 | The Dabie-Sulu UHP rocks belt:review and prospect显示文摘The new results in the studies of the Dabie-Sulu UHP rocks belt during the past 5 years were summarized and discussed. The discussion included the following key points: ( i ) UHP eclogite has two kinds of country rocks, with one being UHP eclogite facies rocks and the other non-UHP granitic gneiss. ( ii ) The FeTiO3 in olivine indicated exsolution at depth of 300-400 km. However, the key point is to prove the peridotite in which the FeTiO3 in olivine was found once had been subducted down that depth. (iii ) UHP hydrous phase evidenced that fluids had taken part in the UHP metamorphism, while the meter-scale inhomogeneous distribution of O-, C-isotope indicated no fluid activity in the deep subduction environment. (iv ) No agreement has been arrived on many problems related to the tectonic background of the UHP rocks, such as 'whether or not ophiolitic rocks there exist now?', 'when did UHP metamorphism proceed?', 'what is the subdution polarity?', etc. ( V ) How did the UHP rocks exhume from mantle | Bolin Cong Qingchen Wang | 1999 | Chinese Science Bulletin1999，44，12： | 21 |
| 4 | Characteristics and dynamic settings of the Central-east Asia multi-energy minerals metallogenetic domain显示文摘That more than 82 percent of proved sandstone-type uranium deposits coexist with proved oil-gas or coalfields in the world reflects the fact of coexistence and accumulation of multi-energy minerals including oil, gas, coal and uranium in the same basin. Especially, this phenomenon is most typical in the Central-east Asia energy basins. Across China, Mongolia and some central Asian countries, the giant Central-east Asia metallogenetic domain (CEAMD) stretches more than 6,000 km from Songliao Basin of China in the east to the Caspian Sea in the west. The multi-energy minerals distribution characteristics of the domain include: their spatial distribution is complicated and ordered; the ore-bearing horizon relates closely to the geographical region; the accumulation/mineralization and localization time is the same or close; the occurrence setting and accumulation/mineralization have close correlation; and they have rich provenance for all the minerals. All of these imply that they have close relations between each other under a unified geodynamic background. The exogenetic uranium mineralization process in CEAMD can be divided into five phases using time limits of 100 Ma, (50±2) Ma, 20±(2―4) Ma, 8―5 Ma. The major mineralization periods and their differences in each primary uranium-bearing basin are identical to the oil-gas accumulation and localization periods and phases in the same basin, and are also in response to regional tectonics and controlled in general by the regional geodynamic environment. For industrial application and commercial exploitation, it is suggested that an important period for coexistence, accumulation and localization of oil, gas, coal and uranium and their interaction mainly occur in the late/last and post basin evolution. Through generalized analysis and comparison of accumulation/mineralization environment of the energy basins in CEAMD, the authors propose that the relatively stable regional tectonic background and moderate (weaker) structural deformation probably are necessary for formation, coexistence and preservation of large and medium-scaled sandstone-type uranium ore deposits, oil-gas fields and coalfields, while basins in favor of coexistence and accumulation are those intracratonal, intermediary massif basins and corresponding reformed basins. | LIU ChiYang QIU XinWei WU BoLin ZHAO HongGe | 2007 | Science China Earth Sciences2007，50，z2： | 13 |
| 5 | Epigenetic mechanism of Survivin dysregulation in human cancer显示文摘Survivin(coding gene BIRC5) is a dual functional protein acting as a critical inhibitor of apoptosis(IAP) and key regulator of cell cycle progression. It is usually produced in embryonic tissues during development and undetectable in most adult tissues.Overexpression of Survivin frequently occurs in various human cancers and increased Survivin correlates with poor clinic outcome, tumor recurrence, and therapeutic resistance. Because of its selective expression in tumor, but not normal tissues,Survivin has been recognized as an attractive target for cancer treatment. Although several therapeutic approaches targeting Survivin are actively under clinical trials in human cancers, to date no Survivin-targeted therapy has been approved for cancer treatment. Numerous studies have devoted to uncovering the underlying mechanism resulting in Survivin dysregulation at multiple levels, such as transcriptional and post-transcriptional regulation. The current article provides a literature review on the transcriptional and epigenetic regulation of Survivin expression in human cancers. We focus on the impact of DNA methylation and histone modifications, including specific lysine methylation, demethylation, and acetylation on the expression of Survivin.The latest development of epigenetic approaches targeting Survivin for cancer treatment are also discussed. | Hui Lyu Jingcao Huang Zhimin He Bolin Liu | 2018 | Science China(Life Sciences)2018，61，7： | 11 |
| 6 | Direct transfer of A20 gene into pancreas protected mice from streptozotocin-induced diabetes显示文摘AIM: To investigate the efficiency of transfer of A20 gene into pancreas against STZ-induced diabetes. METHODS: PVP-plasmid mixture was directly transferred into the pancreatic parenchyma 2 d before STZ injection. The uptake of plasmid pcDNA3-LacZ or pcDNA3-A20 was detected by PCR and the expression of LacZ was confirmed by histological analysis with X-gal. A20 expression in the pancreas of pcDNA3-A20 transgenic mice was measured by RT-PCR and Western blots. Urine amylase, NO generation, and histological examination were examined. RESULTS: Injection of PVP-plasmid mixture directly into the pancreatic parenchyma increased urine amylase concentration 16 h after operation and reversed it to nearly normal 36 h later. On d 33 LacZ expression could be found in spleen, duodenum, and islets. The development of diabetes was prevented by direct A20 gene transferring into the pancreas and A20-mediated protection was correlated with suppression of NO production. The insulitis was ameliorated in A20-treated mice. CONCLUSION: Injection of PVP-plasmid mixture directly into the pancreatic parenchyma led to target gene expression in islets. Direct transfer of A20 gene into the pancreas protected mice from STZ-induced diabetes. | Lu-yangYU BoLIN Zhen-linZHANG Li-heGUO | 2004 | Acta Pharmacologica Sinica2004，25，6： | 9 |
| 7 | Basical characteristics of fluid geologic process of interlayer oxidation zone sandstone-typeuranium deposit显示文摘This paper reveals the physicochemical properties such as component, formulation, genesis, tem- perature, pH, Eh, salinity and pressure of all main alteration fluid of interlayer oxidation zone sand- stone-type uranium deposits after studying the geologic process and geochemistry of internal typical sandstone-type uranium deposits such as Shihongtan deposit in the Turpan-Hami basin, 512 deposit in the Yili basin, Dongsheng deposit in the Ordos basin. The composition of fluid can be divided into two parts based on the analysis of inclusion: one can be affirmed as atmospheric water with ordinary temperature epigenesist according to the character of hydrogen and oxygen isotope of inclusion, the other is natural gas containing gaseous hydrocarbon like CH4, and CO2 as well as a little H2S, CO, H2, N2 and so on, it always contains a small quantity of hydrocarbon liquid in petroliferous basins. The fluid property of oxidation alteration zone is always oxidation alkaline, and neutrality or weak acid-weak alkaline and reducibility during the metallizing process, but at secondary reduction or deoxidization zone it becomes strong reduction alkaline. Oxygenic groundwater in the fluid is the activate and mig- ratory medium of uranium element, but the gaseous hydrocarbon like CH4 as well as H2, H2S, CO from natural gas is the important sedimentary reducer of uranium mineral; the transformation of pH,Eh in fluid environment is the main reason for the formation of uranium metallization. | WU BoLin LIU ChiYang WANG JianQiang | 2007 | Science China Earth Sciences2007，50，z2： | 9 |
| 8 | Driving-Cycle-Aware Energy Management of Hybrid Electric Vehicles Using a Three-Dimensional Markov Chain Model显示文摘This study developed a new online driving cycle prediction method for hybrid electric vehicles based on a three-dimensional stochastic Markov chain model and applied the method to a driving-cycle-aware energy management strategy.The impacts of different prediction time lengths on driving cycle generation were explored.The results indicate that the original driving cycle is compressed by 50%,which significantly reduces the computational burden while having only a slight effect on the prediction performance.The developed driving cycle prediction method was implemented in a real-time energy management algorithm with a hybrid electric vehicle powertrain model,and the model was verified by simulation using two different testing scenarios.The testing results demonstrate that the developed driving cycle prediction method is able to efficiently predict future driving tasks,and it can be successfully used for the energy management of hybrid electric vehicles. | Bolin Zhao Chen Lv Theo Hofman | 2019 | Automotive Innovation2019，2，2： | 7 |
| 9 | Seismic tomography showing subduction and slab breakoff of the Yangtze block beneath the Dabie-Sulu orogenic belt显示文摘Seismic tomography reveals that a subducted ancient block has been preserved beneath the Moho of the Dabie-Sulu orogenic belt. Taking into account of geological and geochronological data, we inferred from the tomographic images that the Yangtze block was subducted northward beneath the Sino-Korean block and broken off at the depth <200 km during 200-190 Ma. The slab breakoff of the Yangtze block is the most important dynamic mechanism to control the exhumation of UHP rocks. | Peifen Xu Ruomei Sun Futian Liu Qingchen Wang Bolin Cong | 2000 | Chinese Science Bulletin2000，45，1： | 7 |
| 10 | System Stability and Instability: A Extended Discussion on Significance and Function of Stirring Energy Conservation Law显示文摘A discussion on significance and function of stirring energy conservation is made further. It is considered that the stirring energy conservation law is an important principle and method for analyses of stability and evolution of systems. It can be applied as both explanations of system stability and method of evolutionary analyses of a system. At the same time, some fundamental problems in the Newtonian system are pointed out. | Chen Gangyi OuYang Bolin Peng Taoyong | 2005 | 工程科学(英文版)2005，3，3： | 7 |
| 11 | Understanding the biology of HER3 receptor as a therapeutic target in human cancer显示文摘HER3 belongs to the human epidermal growth factor receptor(HER) family which also includes HER1/EGFR/erb B1,HER2/erb B2,and HER4/erb B4. As a unique member of the HER family,HER3 lacks or has little intrinsic tyrosine kinase activity. It frequently co-expresses and forms heterodimers with other receptor tyrosine kinases(RTKs) in cancer cells to activate oncogenic signaling,especially the PI-3 K/Akt pathway and Src kinase. Elevated expression of HER3 has been observed in a wide variety of human cancers and associates with a worse survival in cancer patients with solid tumors.Studies on the underlying mechanism implicate HER3 expression as a major cause of treatment failure in cancer therapy. Activation of HER3 signaling has also been shown to promote cancer metastasis. These data strongly support the notion that therapeutic inactivation of HER3 and/or its downstream signaling is required to overcome treatment resistance and improve the outcomes of cancer patients. | Hui Lyu Amy Han Erik Polsdofer Shuang Liu Bolin Liu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 6 |
| 12 | Impact of chronic disease self-management programs on type 2 diabetes management in primary care显示文摘AIM: To assess the effectiveness of the Chronic Disease Self-Management Program(CDSMP) on glycated hemoglobin A1c(HbA1c) and selected self-reported measures.METHODS: We compared patients who received a diabetes self-care behavioral intervention, the CDSMP developed at the Stanford University, with controls whoreceived usual care on their HbA1c and selected self-reported measures, including diabetes self-care activities, health-related quality of life(HRQOL), pain and fatigue. The subjects were a subset of participants enrolled in a randomized controlled trial that took place at seven regional clinics of a university-affiliated integrated healthcare system of a multi-specialty group practice between January 2009 and June 2011. The primary outcome was change in HbA1c from randomization to 12 mo. Data were analyzed using multilevel statistical models and linear mixed models to provide unbiased estimates of intervention effects.RESULTS: Demographic and baseline clinical characteristics were generally comparable between the two groups. The average baseline HbA1c values in the CDSMP and control groups were 9.4% and 9.2%, respectively. Significant reductions in HbA1c were seen at 12 mo for the two groups, with adjusted changes around 0.6%(P < 0.0001), but the reductions did not differ significantly between the two groups(P = 0.885). Few significant differences were observed in participants' diabetes self-care activities. No significant differences were observed in the participants' HRQOL, pain, or fatigue measures.CONCLUSION: The CDSMP intervention may not lower HbA1c any better than good routine care in an integrated healthcare system. More research is needed to understand the benefits of self-management programs in primary care in different settings and populations. | Samuel N Forjuoh Marcia G Ory Luohua Jiang Ann M Vuong Jane N Bolin | 2014 | World Journal of Diabetes2014，5，3： | 6 |
| 13 | Controlled preparation of P-doped g-C3N4 nanosheets for efficient photocatalytic hydrogen production显示文摘Hydrogen production by photolysis of water by sunlight is an environmentally-friendly preparation technology for renewable energy.Graphitic carbon nitride(g-C3N4),despite with obvious catalytic effect,is still unsatisfactory for hydrogen production.In this work,phosphorus element is incorporated to tune g-C3N4's property through calcinating the mixture of g-C3N4 and Na H2PO2,sacrificial agent and co-catalyst also been supplied to help efficient photocatalytic hydrogen production.Phosphorus(P)doped g-C3N4 samples(PCN-S)were prepared,and their catalytic properties were studied.X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),scanning electron microscopy(SEM)and ultraviolet diffuse reflection(UV-DRS)were used to study their structures and morphologies.The results show that the reaction rate of PCN-S is 318μmol·h^-1·g^-1,which is 2.98 times as high as pure carbon nitride nanosheets(CN)can do.Our study paves a new avenue,which is simple,environment-friendly and sustainable,to synthesize highly efficient P doping g-C3N4 nanosheets for solar energy conversion. | Qiachun Lin Zesheng Li Tingjian Lin Bolin Li Xichun Liao Huiqing Yu Changlin Yu | 2020 | Chinese Journal of Chemical Engineering2020，28，10： | 6 |
| 14 | Predictive cruise control for heavy trucks based on slope information under cloud control system显示文摘With the advantage of fast calculation and map resources on cloud control system(CCS), cloud-based predictive cruise control(CPCC) for heavy trucks has great potential to improve energy efficiency, which is significant to achieve the goal of national carbon neutrality. However, most investigations focus on the on-board predictive cruise control(PCC) system,lack of research on CPCC architecture under CCS. Besides, the current PCC algorithms have the problems of a single control target and high computational complexity, which hinders the improvement of the control effect. In this paper, a layered architecture based on CCS is proposed to effectively address the realtime computing of CPCC system and the deployment of its algorithm on vehicle-cloud. In addition, based on the dynamic programming principle and the proposed road point segmentation method(RPSM), a PCC algorithm is designed to optimize the speed and gear of heavy trucks with slope information. Simulation results show that the CPCC system can adaptively control vehicle driving through the slope prediction, with fuel-saving rate of 6.17% in comparison with the constant cruise control. Also,compared with other similar algorithms, the PCC algorithm can make the engine operate more in the efficient zone by cooperatively optimizing the gear and speed. Moreover, the RPSM algorithm can reconfigure the road in advance, with a 91% roadpoint reduction rate, significantly reducing algorithm complexity.Therefore, this study has essential research significance for the economic driving of heavy trucks and the promotion of the CPCC system. | LI Shuyan WAN Keke GAO Bolin LI Rui WANG Yue LI Keqiang | 2022 | Journal of Systems Engineering and Electronics2022，33，4： | 5 |
| 15 | Role of erbB3 receptors in cancer therapeutic resistance显示文摘ErbB3 受体是 erbB 受体酷氨酸 kinases (RTK ) 的独特成员,它经常是在人的癌症的异常地表示的 and/oractivated。不同于在家庭的另外的成员, erbB3 缺乏或损害了 kinase 活动。到 transducecell 发信号, erbB3 不得不与另外的 RTK 交往并且是由它的交互搭挡的 phosphorylated,那些, erbB2is 最重要的。 ErbB3 经常在癌症房间与另外的 RTK 被共同表示激活 oncogenic 发信号,例如 phosphoinositide-3-kinase/protein kinase B ( Akt )小径, 激活mitogen 的蛋白质 kinase kinase ( MEK ) /mitogen-activatedprotein kinase ( MAPK )小径, Janus kinase ( Jak ) /signal 变换器和抄写( Stat )的使活跃之物小径,等等 andthereby 支持 tumorigenesis 。众多的研究证明了 erbB3 发信号的激活玩许多肿瘤的前进打的重要 rolein,例如 erbB2-overexpressing 乳癌,阉割抵抗的 prostatecancer,铂倔强 / 抵抗的卵巢的癌症,表皮的生长因素受体 TKI 抵抗的 non-small-cell 肺癌症,和其它。关于内在的机制的基本研究含有是的 erbB3 的功能治疗 failurein 癌症的一个主要原因治疗。因此, erbB3 的伴随物抑制被认为被要求克服抵抗并且 effectivelytreat 人癌症。这评论在我们到癌症治疗的在 developmentof 抵抗的开始 erbB3 的发信号的理解集中于最近的进展。 | Youngseok Lee JianMa Hui Lyu Jingcao Huang Aeree Kim Bolin Liu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，3： | 5 |
| 16 | Disease gene identification by using graph kernels and Markov random fields显示文摘Genes associated with similar diseases are often functionally related.This principle is largely supported by many biological data sources,such as disease phenotype similarities,protein complexes,protein-protein interactions,pathways and gene expression profiles.Integrating multiple types of biological data is an effective method to identify disease genes for many genetic diseases.To capture the gene-disease associations based on biological networks,a kernel-based Markov random field(MRF)method is proposed by combining graph kernels and the MRF method.In the proposed method,three kinds of kernels are employed to describe the overall relationships of vertices in five biological networks,respectively,and a novel weighted MRF method is developed to integrate those data.In addition,an improved Gibbs sampling procedure and a novel parameter estimation method are proposed to generate predictions from the kernel-based MRF method.Numerical experiments are carried out by integrating known gene-disease associations,protein complexes,protein-protein interactions,pathways and gene expression profiles.The proposed kernel-based MRF method is evaluated by the leave-one-out cross validation paradigm,achieving an AUC score of 0.771 when integrating all those biological data in our experiments,which indicates that our proposed method is very promising compared with many existing methods. | CHEN BoLin LI Min WANG JianXin WU FangXiang | 2014 | Science China(Life Sciences)2014，57，11： | 5 |
| 17 | Biogenic carbonate formation and sedimentation in the Xisha Islands: evidences from living Halimeda显示文摘A recent island survey reveals that the Xuande Atoll and the Yongle Atoll in the Xisha Islands can be classified into one of two systems: the depleted atoll system and growth atoll system; the survey also indicates that the decreased area of several shoals is an unbearable burden for the Xisha Islands, of which the largest island area is 2.13 km2 and the minimum elevation is 1.4 m. According to a survey on the ecological characteristics of Halimeda in the Laolongtou breaker zone of Shidao Island in the Xisha Islands, the green and white living Halimeda are collected,the isotopic ages of 14 C contained in the Halimeda are shown to be 27 years and 55 years, respectively, and carbonate mainly occurs in five types, i.e., luster, segment, sand, sand grain, and marl in the formation. The Halimeda segments mainly provide the carbonate sediments of long-term biogenic deposits in the reef environment and the annual productivity per area is 60–100 g/m2; the characteristics of the microstructure of the Halimeda are analyzed, the aragonite raphide carbonate is deposited and enriched in the cortexes, medullas and cysts, and the Halimeda generally contain major elements such as C, O, Ca, Cl, Mg, K, Na, S and Al, and are rich in trace elements such as tellurium(Te), rhodium(Rh) and strontium. It is believed that the Halimeda grow slowly,including the biotic community of reef corals in the reef areas, thus they possess an environmental remediation capacity, but it takes much time to remedy the environment, and it is necessary to make the law to protect the diversity and vulnerability of the Xisha marine ecology, the ecology of the reef community and the island environment in a scientific way. As indicated in the survey, under the background of global warming and sea-level rise, the discovery of large amounts of Halimeda in the Laolongtou sea area is significant for the natural increase of the depleted atoll system of the Xuande Atoll, while the Halimeda segments represent the primary form of the fossil Halimeda, of which the species can be identified and preserved in great numbers under geological conditions. The Miocene was discovered in large amounts in the Xichen-1 well, therefore the study on the characteristics and mechanism of Halimeda carbonate sediments plays a pivotal role in the formation and construction of organic reefs in the South China Sea as well as oil and gas exploration. | XU Hong ZHAO Xinwei EBERLI G.P. LIU Xinyu ZHU Yurui CAI Ying LUO Wei YAN Guijing ZHANG Bolin WEI Kai SHI Jian | 2015 | Acta Oceanologica Sinica2015，34，4： | 4 |
| 18 | ZERO TRANSMISSION AND ITS APPLICATION IN HIGH SPEED CNC MACHINE TOOLS显示文摘In order to realize high speed machining,the special requirements for the transmission and sturctrue of CNC machine tool have to be satisfied.A high speed spindle unit driven by a built-in motor is developed.An oil-water heat exchange system is used for cooling the spindle motor.The spindle is supported by Si4N3 ceramic ball angular contact bearings. An oil-air lubricator is used to lubricate and cool the spindle bearings.Some special structures are taken for balancing the spindle. | Zhang Bolin, Ma Ping, Xiao Shuhong ,Li Yiping, Xiao Zhanglin (Department of Mechanical and Electronical Engineering,Guangdong University of Technology) | 2000 | Chinese Journal of Mechanical Engineering2000，13，3： | 4 |
| 19 | circPTPN4 regulates myogenesis via the miR-499-3p/NAMPT axis显示文摘Background:Circular RNAs(circ RNAs)are a novel class of endogenous nc RNA,which widely exist in the transcriptomes of different species and tissues.Recent studies indicate important roles for circ RNAs in the regulation of gene expression by acting as competing endogenous RNAs(ce RNAs).However,the specific role of circ RNAs in myogenesis is still poorly understood.In this study,we attempted to systematically identify the circ RNAs involved in myogenesis and analyze the biological functions of circ RNAs in chicken skeletal muscle development.Results:In total,532 circ RNAs were identified as being differentially expressed between pectoralis major(PEM)and soleus(SOL)in 7-week-old Xinghua chicken.Among them,a novel circ RNA(novel_circ_002621),generated by PTPN4 gene,was named circ PTPN4 and identified.circ PTPN4 is highly expressed in skeletal muscle,and its expression level is upregulated during myoblast differentiation.circ PTPN4 facilitates the proliferation and differentiation of myoblast.Moreover,circ PTPN4 suppresses mitochondria biogenesis and activates fast-twitch muscle phenotype.Mechanistically,circ PTPN4 can function as a ce RNA to regulate NAMPT expression by sponging mi R-499-3p,thus participating in AMPK signaling.Conclusions:circ PTPN4 functions as a ce RNA to regulate NAMPT expression by sponging mi R-499-3p,thus promoting the proliferation and differentiation of myoblast,as well as activating fast-twitch muscle phenotype. | Bolin Cai Manting Ma Zhen Zhou Shaofen Kong Jing Zhang Xiquan Zhang Qinghua Nie | 2022 | Journal of Animal Science and Biotechnology2022，13，3： | 4 |
| 20 | Nanosecond photoelectric effects in all-oxide p-n junction of La_(0.9)Sr_(0.1)MnO_(3)/SrNb_(0.01)Ti_(0.99)O_(3)显示文摘Nanosecond (ns) photoelectric effects have been observed in all-oxide p-n junctions of La0.9Sr0.1MnO3/SrNb0.01Ti0.99O3 for the first time. The rise time was about 23 ns and the full width at half maximum was about 125 ns for the open-circuit photovoltaic pulse when the La0.9Sr0.1MnO3 thin film in the p-n junction was irradiated by a laser of ~20 ns pulse duration and 308 nm wavelength. The photovoltaic sensitivity was 80 mV/mJ for a 308 nm laser pulse. | HUANG Yanhong L(U) Huibin HE Meng ZHAO Kun CHEN Zhenghao CHENG Bolin ZHOU Yueliang JIN Kuijuan DAI Shouyu YANG Guozhen | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，3： | 4 |
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