|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CXCL12-CXCR4在人类恶性肿瘤中的生物学功能显示文摘转移和细胞浸润是实体癌和淋巴癌治疗的难点,也是疾病复发和死亡的主要原因。癌细胞的迁移是肿瘤转移和侵袭的前提。CXCL12-CXCR4通路在实体瘤和白血病的发病中发挥重要作用。CXCL12与其受体CXCR4之间的相互作用可以激活多种信号通路,调节不同的生理和病理生理过程。因此,阻断CXCL12-CXCR4的结合和/或下游通路在治疗各种疾病和癌症方面具有临床益处。目前,已发现一些CXCL12和CXCR4拮抗剂,并通过研究证实其在抗肿瘤活性方面取得了令人鼓舞的结果;但这些药物由于其严重的毒副作用未能大规模应用于临床患者。迫切需要研发新型CXCL12-CXCR4轴拮抗剂以治疗肿瘤。本文综述了CXCR4通路在实体肿瘤和白血病中的最新研究进展,并讨论了CXCR4通路在实体肿瘤和白血病中的治疗价值和未来的研究方向。 | 王森 落继先 Istvan Boldogh | 2022 | 中国生物化学与分子生物学报2022，38，5： | 2 |
| 2 | The COVID-19 pandemic and physical activity显示文摘The SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health,economy,and lifestyle.Although the virus usually first invades and infects the lung and respiratory track tissue,in extreme cases,almost all major organs in the body are now known to be negatively impacted often leading to severe systemic failure in some people.Unfortunately,there is currently no effective treatment for this disease.Pre-existing pathological conditions or comorbidities such as age are a major reason for premature death and increased morbidity and mortality.The immobilization due to hospitalization and bed rest and the physical inactivity due to sustained quarantine and social distancing can downregulate the ability of organs systems to resist to viral infection and increase the risk of damage to the immune,respiratory,cardiovascular,musculoskeletal systems and the brain.The cellular mechanisms and danger of this“second wave”effect of COVID-19 to the human body,along with the effects of aging,proper nutrition,and regular physical activity,are reviewed in this article. | Jeffrey A.Woods Noah T.Hutchinson Scott K.Powers William O.Roberts Mari Carmen Gomez-Cabrera Zsolt Radak Istvan Berkes Anita Boros Istvan Boldogh Christiaan Leeuwenburgh Helio Jose Coelho-Júnior Emanuele Marzetti Ying Cheng Jiankang Liu J.Larry Durstine Junzhi Sun Li Li Ji | 2020 | Sports Medicine and Health Science2020，2，2： | 2 |
| 3 | Tumor necrosis factor-alpha-inducible 1 kappa B alpha proteolysis mediated by cytosolie m-calpain-A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappa B activation显示文摘 | Han YQ Weinman S Boldogh I | 1999 | J Biol Chem1999，274，2： | 1 |
| 4 | Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress 显示文摘 | Boldogh I Roy G Lee MS | 2003 | Toxicology2003，193，13： | 1 |
| 5 | Apoptosis induced bypersistent single-strand breaks in mitochondrial genome: criticalrole of EXOG (5'-EXO/endonuclease) in their repair 显示文摘 | Tann AW Boldogh I Meiss G | 2011 | J BiolChem2011，286，31： | 1 |
| 6 | Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress显示文摘 | Boldogh I Roy G Lee MS | 2003 | Toxicology2003，193，12： | 1 |
| 7 | Tumor necrosis factor-alpha-inducible IKappaBalpha proteo-Lysis mediated by cytosolic m-calpain显示文摘 | Han Y Weinman S Boldogh I | 1999 | J Biol Chem1999，274，2： | 1 |
| 8 | Redox-regulating sirtuins in aging, caloric restriction, and exercise显示文摘 | Zsolt Radak Erika Koltai Albert W. Taylor Mitsuru Higuchi Shuzo Kumagai Hideki Ohno Sataro Goto Istvan Boldogh | 2013 | Free Radical Biology and Medicine2013，，： | 1 |
| 9 | Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals显示文摘 | RAMANA C V BOLDOGH I IZUMI T | 2005 | Proc Natl Acad Sci USA2005，95，9： | 1 |
| 10 | CyclinE/Cdk2 activity is con - trolled by different mechanisms in the GO and G1 phases of the cell cycle 显示文摘 | Bresnahan WA Boldogh I Ma T | 1996 | Cell Growth and Differentiation1996，7，： | 1 |
| 11 | Human eytomegalovirus inhibits cellular DNA synthesis and arrests productively infected cells in late G1 显示文摘 | Bresnahan WA Boldogh I Thompson EA | 1996 | Virology1996，224，： | 1 |
| 12 | The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1 显示文摘 | Das A Boldogh I Lee JW | 2007 | J Biol Chem2007，282，26： | 1 |
| 13 | Latent infection of mouse cells with human cytomegalovirus显示文摘 | Boldogh I Gonczol E Gartner L | | 0，，03： | 1 |
| 14 | Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage显示文摘 | Mitra S Boldogh I Izumi T | 2008 | Environ Mol Mutagen2008，38，23： | 1 |
| 15 | Hydrolysis of inositol lipids:an early signal of human cytomegalovirus infection显示文摘 | Valyi-Nagy T Bandi Z Boldogh I | 1988 | Arch Virol1988，101，34： | 1 |
| 16 | 8-Oxo-7, 8-dihydroguanine: links to gene expression, aging, and defense against oxidative stress 显示文摘 | Radak Z Boldogh I | 2010 | Free Radic Biol Med2010，49，4： | 1 |
| 17 | Lactoferrin in health and disease显示文摘 | Kruzel ML Aetor JK Boldogh I | 2007 | Postepy Hig Med Dosw2007，61，： | 1 |
| 18 | hMYH cell cycle-dependent expression,subcellular localization and association with replication foci:evidence suggesting replicationcoupled repair of adenine:8-oxoguanine mispairs显示文摘 | BOLDOGH I MILLIGAN D LEE M S | 2001 | Nucleic Acids Res2001，29，13： | 1 |
| 19 | Human cytomegalovirus inhibits cellular DNA synthesis and arrests productively infected cells in late G1 显示文摘 | Bresnahan WA Boldogh I Thompson EA | 2007 | Virology2007，224，1： | 1 |
| 20 | Humancytomegalovirus inhibits cellular DNA synthesis and arrests productively infected cells in late G1显示文摘 | Bresnahan WA Boldogh I Thompson EA | 1996 | Virology1996，224，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员