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| 1 | Acute pancreatitis in aging animals:Loss of pancreatitis-associated protein protection?显示文摘AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old rats.Sera and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal RNA.RESULTS:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± SE histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P < 0.05),decreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P < 0.05) and increased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P < 0.05).A decreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical staining.There were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 levels.However,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P < 0.05).CONCLUSION:In older animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course. | Sophia Fu Albert Stanek Cathy M Mueller Nefertti A Brown Chongmin Huan Martin H Bluth Michael E Zenilman | 2012 | World Journal of Gastroenterology2012，18，26： | 5 |
| 2 | Use of gene expression profiles in cells of peripheral blood to identify new molecular markers of acute pancreatitis显示文摘 | Bluth M Lin YY Zhang H | 2008 | Arch Surg2008，143，3： | 1 |
| 3 | 2012 ACCF/AHA/ ACR/SCAI/SIR/STS/SVM/SVN/SVS Key data elements and definitions for peripheral atherosclerotic vascular disease : a report of the American College of Cardiology Foundation/American Heart Association Task Force on Clinical Data Standards (Writing Committee to develop Clinical Data Standards for peripheral atherosclerotic vascular disease) 显示文摘 | Creager MA Belkin M Bluth EI | 2012 | J Am Coil Cardiol2012，59，3： | 1 |
| 4 | Delayed posterior dislocation of silicone plate-haptic lenses after neodymium:yag capsulotomy显示文摘 | Petersen AM Bluth LL Campion M | 2000 | Journal of cataract and refractive surgery2000，26，12： | 1 |
| 5 | R?ntgenographic measu- rements of expansion of crystalline masses 显示文摘 | BüSSEM W BLUTH M GROCHMANN G | 1935 | Ber Deut Keram Ges1935，16，： | 1 |
| 6 | 2012 ACCF/AHA/ACR/ SCAI/SIR/STS/SVM/SVN/SVS key data elements and definitions for peripheral atherosclerotic vascular disease: a report of the American College of Cardiology Foundation/ American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Clinical Data Standards for Peripheral Atherosclerotic Vascular Disease)显示文摘 | Creager MA Belkin M Bluth EI | 2012 | Circulation2012，125，2： | 1 |
| 7 | Successful use of recombinant activated factor Ⅶ for trauma-associated hemorrhage in a patient without preexisting coagulopathy显示文摘 | O'Neill PA Bluth M Gloster ES | 2002 | J Trauma2002，52，2： | 1 |
| 8 | Synergy between tumor necrosis factor alpha and interleukin-1 in the induction of sickness behavior in mice显示文摘 | Bluthe RM Pawlowski M Suarez S | 1994 | Psych Oneuroendocrinology1994，19，2： | 1 |
| 9 | Validation of a method based on polymerase chain reaction for the detection of genetically modified organisms in various processed foodstuffs显示文摘 | Lipp M Bluth A Eyquem F | 2001 | Eur Food Res Technol2001，212，： | 1 |
| 10 | Sulfide-sulfate chimneys on the East Pacific Rise, 11 degrees and 13 degrees N latitudes: Part I, Mineralogy and paragenesis显示文摘 | Graham U M Bluth G J and Ohmoto H | 1988 | The Canadian Mineralogist1988，26，3： | 1 |
| 11 | The va-gus nerve mediates behavioural depression,but not fever,in response to peripheral immune signals? a functional an-atomical analysis 显示文摘 | Konsman J P Luheshi G N Bluthe R M | 2000 | Eur J Neurosci2000，12，12： | 1 |
| 12 | Successful use of recombinantactivated factor W for trauma -associated hemorrhage in a patientwithout preexisting coagulopathy显示文摘 | O’Neill PA Bluth M Gloster ES | 2002 | J Trauma2002，52，2： | 1 |
| 13 | 2012 key data elements and definitions for peripheral atherosclcrotic vascular disease: a report of the American College of Cardiology Foundafion/Amedcan Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Clinical Data Standards for Peripheral Atherosclerotic Vascular Disease) 显示文摘 | Creagcr MA Belkin M Bluth EI ACCF/AHA/A | 2012 | Circulation2012，125，2： | 1 |
| 14 | Cytokine-induced sickness behavior显示文摘 | Kelley K W Bluthe R M Dantzer R | 2003 | Brain Behav Immun2003，17，1： | 1 |
| 15 | The va-gus nerve mediates behavioural depression,but not fe-ver ? in response to peripheral immune signals; a func-tional anatomical analysis显示文摘 | Konsman J P Luheshi G N Bluthe R M | 2000 | Eur J Neurosci2000，12，12： | 1 |
| 16 | Lipopolysaccharide induces sickness behavior in rats by a vagal mediated mechanism显示文摘 | Bluthe R M Walter V Parnet P | 1994 | C R Acad Sci III1994，317，： | 1 |
| 17 | Use of top -level structure in text:Key for reading comprehension of ninth-grade students显示文摘 | MEYER B J F BRANDT D M BLUTH G J | 1980 | Reading Research Quarterly1980，，16： | 1 |
| 18 | Use of gene expression profiles in cells of peripheral blood to identify new molecular markers of acute pancreatitis 显示文摘 | Bluth M Liu YY Zhang H | 2008 | Arch Surg2008，143，3： | 1 |
| 19 | Equation of State Calculations by Fast Computing Machines显示文摘 | METROPOLIS N ROSENBLUTH A W ROSEN- BLUTH M N | 1953 | Journal of Chemi- cal Physics1953，21，6： | 1 |
| 20 | Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin-1显示文摘 | Kent S Bluthe R M Dantzer R | 1992 | Proc Natl Acad Sci USA1992，89，： | 1 |
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