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| 1 | 我国面临快速增长的终末期肾病治疗负担显示文摘目的报告2008年我国终末期肾脏病维持性透析患病率和发病率,并估计未来维持性透析的趋势。方法中国医院协会血液净化中心管理分会制定调查表,以透析登记软件及纸质版形式下发至各省、自治区和直辖市的血液净化中心管理分会/血液净化质量控制中心,收集各透析室的数据,包括2007年底和2008年底患者数量,以及2008年新进入透析的患者数量;患者的性别和年龄构成;导致终末期肾脏病(ESRD)的原因以及所有死亡患者的原因。分析2007和2008年底ESRD的点患病率、2008年ESRD发病率、ESRD病因以及死亡原因构成。结果全国31个省、自治区和直辖市中,27个应答。2007年底,共报告65074例ESRD患者,点患病率为每百万人口51.7;2008年底患者数增至102863例,点患病率为每百万人口79.1,患病率增长52.9%。2008年ESRD新患者数为45423例,发病率每百万人口36.1。ESRD的病因依次为肾小球肾炎(45%)、糖尿病(19%)、高血压(13%)、多囊肾病(2%)和其他或未知(20%)。ESRD主要死亡原因是心血管疾病(31%)、中风(20.3%)、感染(19.9%)和其他(28.8%)。结论虽然我国ESRD的患病率显著低于其他亚洲国家和地区,但发病率极高,未来几年患病率也将快速增加,从而增加我国ESRD的治疗负担。 | Li Zuo M.D.1 and Mei Wang M.D.2 for Chinese Society of Blood Purification Institute of Nephrology,Peking University First 1 Hospital Institute of Nephrology,Peking University People’s Hospital 2 | 2010 | 中国血液净化2010，，1： | 145 |
| 2 | Full-thickness tissue engineered skin constructed with autogenic bone marrow mesenchymal stem cells显示文摘To explore the feasibility of repairing clinical cutaneous deficiency, autogenic bone marrow mesen-chymal stem cells (BMSCs) were isolated and differentiated into epidermal cells and fibroblasts in vitro supplemented with different inducing factors and biomaterials to construct functional tissue- engineered skin. The results showed that after 72 h induction, BMSCs displayed morphologic changes such as typical epidermal cell arrangement, from spindle shape to round or oval; tonofibrils, melano-somes and keratohyaline granules were observed under a transmission electronic microscope. The differentiated cells expressed epidermal stem cell surface marker CK19 (59.66% ± 4.2%) and epidermal cells differentiation marker CK10. In addition, the induced epidermal cells acquired the anti-radiation capacity featured by lowered apoptosis following exposure to UVB. On the other hand, the collagen microfibrils deposition was noticed under a transmission electronic microscope after differentiating into dermis fibroblasts; RT-PCR identified collagen type I mRNA expression in differentiated cells; radioimmunoassay detected the secretion of interleukin-6 (IL-6) and interleukin-8 (IL-8) (up to 115.06 pg/mL and 0.84 ng/mL, respectively). Further in vivo implanting BMSCs with scaffold material short-ened skin wound repair significantly. In one word, autogenic BMSCs have the potential to differentiate into epidermal cells and fibroblasts in vitro, and show clinical feasibility acting as epidermis-like and dermis-like seed cells in skin engineering. | HE LiJuan, NAN Xue, WANG YunFang, GUAN LiDong, BAI CiXian, SHI ShuangShuang, YUAN HongFeng, CHEN Lin, LIU DaQing & PEI XueTao Laboratory of Stem Cells and Regenerative Medicine, Institute of Blood Transfusion, Academy of Military Medical Sciences, Beijing 100850, China | 2007 | Science China(Life Sciences)2007，50，4： | 16 |
| 3 | A prospective randomized antiplatelet trial of cilostazol versus clopidogrel in patients with bare metal stent显示文摘Background Cilostazol is a newly developed antiplatelet drug that has been widely applied for clinical use. Its antiplatelet action appears to be mainly related to inhibition of intracellular phosphodiesterase activity. Recently, cilostazol has been used for antiplatelet therapy after coronary bare metal stent implantation for thrombosis and restenosis prevention. This prospective randomized and double blind trial was designed to investigate the safety and efficacy of cilostazol for the prevention of late restenosis and acute or subacute stent thrombosis. Methods One hundred and twenty patients who underwent elective stent were randomly assigned to treatment group with cilostazol 200 mg/d (n = 60), clopidogrel 75 mg/d and aspirin 100 mg/d or to control group with clopidogrel treatment 75 mg/d (n = 60) and aspirin 100 mg/d. Follow-up coronary angiography was performed 6-9 months later. Results Nine months major adverse cardio-cerebral event (MACCE) were lower in treatment groups (P<0.05). The quantitative coronary angiography (QCA) at 6 months follow-up showed that minimum lumen diameter (MLD) was higher in treatment group than that of control group [(2.14±0.52)mm vs (1.82±0.36)mm, P<0.05]. Late lumen loss (LL) [(0.82±0.42)mm vs (1.31±0.58)mm; P<0.01], restenosis rate (RR) (14% vs 32%; P<0.05) and target lesion revascularizaion (TLR) rate (5% vs 17%; P<0.05) were lower in treatment group than in control group. Conclusion Cilostazol therapy is an effective regimen for prevention not only stent thrombosis but also RR and TLR through reducing MLD without the risk of increasing bleeding. | CHEN Yun-dai, LU Yan-ling, JIN Ze-ning, YUAN Fei and Lü Shu-zhengDepartment of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences Beijing Institute of Heart, Lung and Blood Vessel, Beijing 100029, China | 2006 | Chinese Medical Journal2006，，5： | 15 |
| 4 | Vein transplantation using human umbilical cord blood stem cells in the treatment of stroke sequela显示文摘BACKGROUND: Transplanted mononuclear cell(MNC)of umbilical blood can survive in central nervous system (CNS)of host through blood brain barrier,differentiate into nerver cells,migrate to damaged site and integrate morphological strucgh and function with nerve cells of host so as to improve deficiencies of sensatory function,motor function and cognitive function and influence on stroke sequela.OBJECTIVE: To observe the vein transplantation of human umbilical cord blood stem cells(HUCBSC) for improving neurological function,limb funtion and activity of daily living of patients with stroke and evaluate the reliability.DESIGN: Self-controlled study.SETTING: Department of Neurosurgery,the Second People's Hospital of Zhengzhou City;Red-crossed Blood Center of Henan Province;Department of Neurosurgery,the Fist Affiliated Hospital of Zhenzhou University.PARTICIPANTS:A total of 10 patients with stoke sequela were selected from Department of Cerebral Surgery,the Second People's Hospital of Zhengzhou City from April to December 2005.There were 9males and 1 female aged from 35to 75years with the mean age of 56 years.All of them were diagnosed with CT and MRI examination and coincidence with diagnostic criteria of stroke established by the Fourth National Academic Meeting for Cerebrovascular Disease.All patients provided informed consent. METHODS:80-140 mL umbilical blood of term birth of newborn was selected hermetically and maintained in sterile plastic bag.And then,the blood was centrifugated at the speed of 1500 r/min for 30 minutes at 22℃ in order to separate MNC,i.e.,HUCBSC.In addition,after final diagnosis during hospitalization,stroke patients were perfused with HUCBSC through superficial vein of back of the hand.Each patient was averagely penfused with 6 portions of HUCBSC(cellular numbers≥1×108/portion)and the interval between each portion was 1-7 days with the mean interval of 4 days.MAIN OUTCOME MEASURES: ①Neurological function of stroke patients was evaluated with neurological function deficiency(NFD)before treatment and at 3 months after treatment.The scale includes consciousness,level fix function.facial paralysis,language,muscle force of upper limbs,muscle force of lower limb and step function.The total scores ranged from 0 to 45; meanwhile,the lower the scores were,the better the neurological function of limbs was. ②Motor function of injured limbs was evaluated with Fugl-Meyer Assessment (FMA),including motor function of upper limbs.motor function of lower limbs,balance ability,sensory function and motion of joint.The total scores ranged from 0 to 226;meanwhile,the higher the scores were,the better the motor function of limbs was.③Activities of daily living(ADL)was evaluated with Barthel Index(BI),including having meals,taking a bath,dressing oneself,putting on clothes,walking in balance and stair activity.The total scores ranged from 0 to 100;meanwhile,the higher the scores were,the stronger the ADL was.RESULTS:A total of 10 patients were involved in the final analysis.After treatment,NFD of stroke patients was (10.9±5.09)points,which was lower than that before treatment[(25.4±6.09)points,t=8.213,P<0.01].In addition,after treatment,FMA and BI of stroke patients were(80.9±25.00)points and(81.1±15.93)points,re spectively,which were higher than those before treatment[(31.9+21.85)points,(36.2+19.41)points,t=13.024,13.670,P<0.01]. Immuno-suppressive drugs were not used during the whole therapeutic procedure;moreover,immunological rejection and allergic reaction were not observed during the same period.CONCLUSION:Transplanting HUCBSC through superficial vein of back of the hand is regarded as a simple and safe method for the treatment of stroke sequela. | Yong Man1, Jianbin Li2, Bo Yang3, Ji Ma1 1Department of Cerebral Surgery, the Second People’s Hospital of Zhengzhou, Zhengzhou 450000, Henan Province, China 2Red Cross Blood Center of Henan Province, Zhengzhou 450000, Henan Province, China 3Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China | 2006 | Neural Regeneration Research2006，1，7： | 7 |
| 5 | Expert consensus on the establishment and maintenance of native arteriovenous fistula显示文摘Vascular access is the lifeline of hemodialysis patients.There are great differences in the establishment and use of vascular access in different countries and regions around the world.We believe that on the basis of good evaluation and planning,it is recommended that hemodialysis patients choose native arteriovenous fistula first.In view of the new progress of vascular access views domestic and international at home and abroad in recent years,we organized experts to recommend the establishment and maintenance of arteriovenous fistula(AVF)for the Chinese population,including preoperative evaluation and planning of the establishment of AVF,AVF surgery,perioperative drug intervention measures and postoperative maintenance,and put forward suggestions for future research directions.The recommendations in this consensus are general and clinicians need to make treatment decisions based on the actual situation. | Hongtao Zhang Haitao Lu Wenge Li Gengru Jiang Hongbin Zou Expert Group of Nephrology Branch of China Academy of Chronic Disease Urology Nephrology and Blood Purification Commission of China Medical Education Association | 2021 | Chronic Diseases and Translational Medicine2021，7，4： | 3 |
| 6 | InGa As/Ga As量子点类脊型激光器的激射特性显示文摘用MOCVD方法生长制备了多层InGaAs/GaAs量子点结构 ,并研制出量子点激光器。研究了多层量子点激光器阈值激射特性与量子点有源区结构之间的关系 ,结果表明激光器的阈值电流密度依赖于量子点的结构。通过采用多层量子点、对量子点层间进行耦合以及采用宽禁带AlGaAs作为量子点层势垒可以有效地降低激光器的阈值电流密度。获得了最低为 2 0A/cm2 的平均阈值电流密度。量子点激光器的激射波长也与有源区结构有关 ,随着量子点层数增加 ,激射峰向长波方向移动。 | 宁永强 高欣 王立军 Peter Smowton Peter Blood | 2002 | 中国激光2002，29，4： | 3 |
| 7 | Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy显示文摘 | National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy | 2000 | American Journal of Obstetrics and Gynecology2000，，1： | 2 |
| 8 | 宣教循证视频辅助决策对患者选择脊柱手术的影响显示文摘面对多个临床治疗方案,病人常常难以选择。决策辅助可增强患者对于疾病的认识,对减少决策冲突,提高患者在决策中的积极性有重要意义。 | Lurie JD Spratt KF Blood EA 陈旭琼 尹庆水 | 2011 | 中国骨科临床与基础研究杂志2011，3，3： | 2 |
| 9 | Tumor interactions with the vascular:angiogenesis and tumor metastasis显示文摘 | BLOOD C H ZELTER B R | 1990 | Biochem Biophys Acta1990，1032，1： | 2 |
| 10 | Executive summary of the third report of the National Cholesterol Education Program(NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III ) 显示文摘 | Expert Panel on Detection Evaluation and Treatment of High Blood Cholesterol in Adults | 2001 | JAMA2001，285，19： | 1 |
| 11 | Executive summary of the third report of the national cholesterol education program expert panel on detection,evaluation,and treatment of high blood cholesterol in adults (adult treatment panelⅢ)显示文摘 | Evaluation and treatment of high blood cholesterol in adults | 2001 | JAMA2001，285，： | 1 |
| 12 | Update on the 1987 task force report on high blood pressure in children and adolescents:A working group report from the national high blood pressure education program 显示文摘 | National heart lung and blood institute | 1996 | Pediatrics1996，98，4： | 1 |
| 13 | Tumor interactions vasculature: angiogenesis and tumor metastasis显示文摘 | Blood CH Getter BR | 1990 | Biochlm Biophys Acta1990，1032，7： | 1 |
| 14 | Report on hypertension in diabetes显示文摘 | National High Blood Pressure Education Program Working Group | 1994 | Hypertension1994，23，2： | 1 |
| 15 | with ischemic heart disease显示文摘 | Pascei V etAssociatio of virrlent helicobacter pylori strains with is cthelin and calcitonin gene-related peptide in patients with essential hypertension of different blood pressure grades and their changes after felodipine treatment | 1998 | Circulation1998，97，： | 1 |
| 16 | The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents 显示文摘 | National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents | 2004 | Pediatrics2004，114，2： | 1 |
| 17 | Myeloma and the t( 11; 14) (q13;q32); evidence for a biologically defined unique subset ofpatients显示文摘 | Fonseca R Blood EA Oken MM | 2002 | Blood2002，99，10： | 1 |
| 18 | Phase Ⅲ study of PSC833 (valspodar) in combination with vincdstine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (ElA95): a trial of the Eastern Cooperative Ontology Group显示文摘 | FRIEDEBERG WR RUE M Blood EA | 2006 | Cancer2006，106，4： | 1 |
| 19 | The fourth report on the diagnosis, evaluation and treatment of high blood pressure in children and adolescents显示文摘 | Nalional high blood pressure education program working group on high blood pressure in children and adolescents | 2004 | Pediatrics2004，114，24： | 1 |
| 20 | Implications on post - transfusion immunomodulation and transfusionassociated GVHD显示文摘 | Mincheff M : Changes in donor leukocytes during blood storage | 1998 | Vox Sang1998，74，2： | 1 |
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