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| 1 | Successful aspiration and ethanol sclerosis of a large,symptomatic, simple liver cyst:Case presentation and review of the literature显示文摘简单的肝包囊与 2.5%-4.25% 的流行是先天的。成像,是否由美国, CT 或 MRI,在把简单包囊与另外的病原学区分开来是精确的,包括寄生,肿瘤,管相关,并且创伤性囊肿。征兆的简单的肝包囊是稀罕的,并且症状的真频率不被知道。征兆的简单的肝包囊主要大(>
4 厘米) ,在女人右边、更普通、更老的病人。绝大多数简单肝的包囊不要求治疗或后续,尽管大包囊(>
4 厘米) 可以开始与连续成像被跟随保证稳定性。到大简单包囊的症状的归属应该小心地被承担,在选择诊断以后被排除了。渴望可以被执行测试症状是否由于包囊;然而,包囊复发应该被期望。有 laparoscopic deroofing 和渴望的有限经验,由一个致硬化的代理人的灌输列在后面为征兆的包囊的治疗表明了有希望的结果。这里,我们与大、征兆的、简单的肝包囊描述一个病人经历了症状的完全的分辨率后面的包囊排水和白酒脱离,和我们在场文学的全面评论。 | Wojciech C Blonski Mical S Campbell Thomas Faust David C Metz | 2006 | World Journal of Gastroenterology2006，12，18： | 50 |
| 2 | Non-viral causes of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignancy and represents an international public health concern as one of the most deadly cancers worldwide.The main etiology of HCC is chronic infection with hepatitis B and hepatitis C viruses.However,there are other important factors that contribute to the international burden of HCC.Among these are obesity,diabetes,non-alcoholic steatohepatitis and dietary exposures.Emerging evidence suggests that the etiology of many cases of HCC is in fact multifactorial,encompassing infectious etiologies,comorbid conditions and environmental exposures.Clarification of relevant non-viral causes of HCC will aid in preventative efforts to curb the rising incidence of this disease. | Wojciech Blonski David S Kotlyar Kimberly A Forde | 2010 | World Journal of Gastroenterology2010，16，29： | 25 |
| 3 | Liver transplantation for metastatic neuroendocrine tumor: A case report and review of the literature显示文摘Neuroendocrine tumors are divided into gastrointestinal carcinoids and pancreatic neuroendocrine tumors. The WHO has updated the classification of these lesions and has abandoned the term 'carcinoid'. Both types of tumors are divided into functional and non-functional tumors. They are characterized by slow growth and frequent metastasis to the liver and may be limited to the liver for long periods. The therapeutic approach to hepatic metastases should consider the number and distribution of the liver metastases as well as the severity of symptoms related to hormone production and tumor bulk. Surgery is generally considered as the first line therapy. In patients with unresectable liver metastases,alternative treatments are dependent on the type and the growth rate. Initial treatments consist of long acting somatostatin analogs and/or interferon. Streptozocinbased chemotherapy is usually reserved for symptomatic patients with rapidly advancing disease, but generally the therapy is poorly tolerated and its effects are short-lived.Locoregional therapy directed such as hepatic-artery embolization and chemoembolization, radiofrequency thermal ablation and cryosurgery, is often used instead of systemic therapy, if the disease is limited to the liver.However, liver transplantation should be considered in patients with neuroendocrine metastases to the liver that are not accessible to curative or cytoreductive surgery and if medical or locoregional treatment has failed and if there are life threatening hormonal symptoms. We report a case of liver transplantation for metastatic neuroendocrine tumor of unknown primary source and provide a detailed review of the world literature on this controversial topic. | Wojciech C Blonski K Rajender Reddy Abraham Shaked Evan Siegelman David C Metz | 2005 | World Journal of Gastroenterology2005，11，48： | 5 |
| 4 | Non-pulmonary allergic diseases and inflammatory bowel disease: A qualitative review显示文摘While the etiological underpinnings of inflammatory bowel disease(IBD) are highly complex, it has been not-ed that both clinical and pathophysiological similarities exist between IBD and both asthma and non-pulmonary allergic phenomena. In this review, several key points on common biomarkers, pathophysiology, clinical manifesta-tions and nutritional and probiotic interventions for both IBD and non-pulmonary allergic diseases are discussed.Histamine and mast cell activity show common behav-iors in both IBD and in certain allergic disorders. IgE also represents a key immunoglobulin involved in both IBD and in certain allergic pathologies, though these links require further study. Probiotics remain a critically important intervention for both IBD subtypes as well as multiple allergic phenomena. Linked clinical phenomena, especially sinonasal disease and IBD, are discussed. In addition, nutritional interventions remain an underuti-lized and promising therapy for modification of both al-lergic disorders and IBD. Recommending new mothers breastfeed their infants, and increasing the duration of breastfeeding may also help prevent both IBD and al-lergic diseases, but requires more investigation. While much remains to be discovered, it is clear that non-pulmonary allergic phenomena are connected to IBD in a myriad number of ways and that the discovery of com-mon immunological pathways may usher in an era of vastly improved treatments for patients. | David S Kotlyar Mili Shum Jennifer Hsieh Wojciech Blonski David A Greenwald | 2014 | World Journal of Gastroenterology2014，20，32： | 5 |
| 5 | A Systematic Review of Factors That Contribute to Hepatosplenic T-Cell Lymphoma in Patients With Inflammatory Bowel Disease显示文摘 | David S. Kotlyar Mark T. Osterman Robert H. Diamond David Porter Wojciech C. Blonski Mariusz Wasik Sami Sampat Manuel Mendizabal Ming V. Lin Gary R. Lichtenstein | 2011 | Clinical Gastroenterology and Hepatology2011，，1： | 3 |
| 6 | Papillary thyroid cancer and inflammatory bowel disease:Is there a relationship?显示文摘AIM:To formally study age of diagnosis of papillary thyroid cancer(PTC) in inflammatory bowel disease(IBD) patients and evaluate the prevalence of PTC in IBD patients compared to a control population.pothesis that patients with IBD are more likely to be diagnosed with PTC than a control population.A retrospective cohort analysis was performed using the University of Pennsylvania Health System's electronic database.Outpatients from 1998-2009 were included in the search,and patients in the cohort were selected based on ICD-9 codes.Inclusion criteria included the diagnosis of Crohn's disease(CD) or ulcerative colitis(UC) and the concurrent diagnosis of thyroid cancer in comparison to a control population.Using these methods 912 patients with CD and 1774 with UC were compared to 1638 diverticulitis and 19 447 asthma controls.Statistics were performed using corrected chisquare analysis.The primary outcome for this study was the diagnosis of PTC.Approval to conduct this study was obtained by the Institutional Review Board at the University of Pennsylvania.RESULTS:The mean age was 47.5 years(range:18-102 years) and 66% patients were female.An analysis of variance model was used to compare the age of PTC diagnosis between the CD,UC,asthma and diverticulitis groups,and a statistically significant difference in age at PTC diagnosis was noted across all groups(F = 6.35,df = 3,P = 0.0006).The age of PTC diagnosis in CD patients was statistically significantly lower than UC,asthma,and diverticulitis patients(average PTC diagnosis age for CD 25,UC 49,asthma 45,diverticulitis 63).After covarying for sex and age in 2009,the difference in age at PTC diagnosis remained statistically significant(F = 4.13,df = 3,P = 0.0089).A total of 86 patients were diagnosed with PTC.Nine patients(0.5%) with UC were diagnosed with PTC.Patients with UC were not shown to be more likely to develop PTC [odds ratio(OR):1.544,95%CI 0.767-3.108] compared to asthma controls.Four patients(0.4%) with CD were diagnosed with PTC.Patients with CD were not shown to be more likely to develop PTC(OR:1.334,95%CI 0.485-3.672) compared to a control population with asthma.Nine patients(0.5%) with a history of diverticulitis were diagnosed with PTC.Patients with diverticulitis were not shown to be more likely to develop PTC(OR:1.673,95%CI 0.831-3.368) compared to asthma controls.Patients with CD or UC were not less likely to develop PTC compared to those with diverticulitis(CD OR:0.80,95%CI 0.25-2.60;UC OR:0.92,95%CI 0.37-2.33).None of the patients used immunosuppressant medications prior to the diagnosis of PTC(azathioprine,6-mercaptopurine,and methotrexate).CONCLUSION:There is a significant difference in age of diagnosis of PTC in patients with CD compared to patients with UC and the control populations studied. | Irene S Sonu Wojciech Blonski Ming Valerie Lin James Lewis Faten Aberra Gary R Lichtenstein | 2013 | World Journal of Gastroenterology2013，19，7： | 2 |
| 7 | Complex for- mation and ion ieeonductivity of polyphosphazene solid elee- trolytes显示文摘 | Blonsky P M Shriver D F Austin P E | 1986 | Solid State Ionies1986，18，： | 1 |
| 8 | The subcellular localization of cyclin dependent kinase 2 determines the fate of mesangial cells: role in apoptosis and proliferation 显示文摘 | HIROMURA K PIPPIN J W BLONSKI M J | 2002 | Oncogene2002，21，11： | 1 |
| 9 | 显示文摘 | Robak T Blonski JZ Kasznicki M | 2000 | Blood2000，96，： | 1 |
| 10 | Polymeric electro lytes显示文摘 | Blonsky P M Clancy S Hardy L C | 1987 | Chemtechnolygy1987，12，： | 1 |
| 11 | Mechanical stress reduces podocyte proliferation in vitro 显示文摘 | Petermann AT Hiromura K Blonski M | 2002 | Kidney Int2002，61，1： | 1 |
| 12 | Polyphosp hazene solid electrolytes显示文摘 | Blonsky P M Shriver D F Austin P E | 1984 | J Am Chem Soc1984，1，06： | 1 |
| 13 | Cladribine combined with cyclophosphamide and mitoxantrone is an active salvage therapy in advanced non-Hodgkin’s lymphoma显示文摘 | Tadeusz Robak Ewa Lech-Maranda Agnieszka Janus Jerzy Blonski Agnieszka Wierzbowska Joanna Gora-Tybor | 2007 | Leukemia & Lymphoma2007，，6： | 1 |
| 14 | Cladribine alone and in combination with cyclophos-phamide or cyclophosphamide plus mitoxantrone in the treatment of progressive chronic lymphocytic leukemia: report of prospective, multi-center, randomized trial of the Polish Adult Leukemia Group (PALG CLL2)显示文摘 | Robak T Blonski JZ Gora-Tybor J | 2006 | Blood2006，108，： | 1 |
| 15 | Combination of neoa- djuvant chemotherapy followed by surgical resection as a new strategy for WHO grade H gliomas:a study of cognitive status and quality of life显示文摘 | Blonski M Taillandier L Herbet G | 2012 | J Neurooncol2012，106，： | 1 |
| 16 | Polyphosphazene solid electrolyte显示文摘 | P M Blonsky D F Shriver P Austin | 1984 | J Am Chem Soc1984，106，： | 1 |
| 17 | Podocytes that detach in experimental membranous nephropathy are viable显示文摘 | Petermann AT Krofft R Blonski M | 2003 | Kidney Int2003，64，4： | 1 |
| 18 | Podocytes that detach in experimental membranous nephropathy are viable显示文摘 | Petermann AT Krofft R Blonski M | 2003 | Kidney Int2003，64，4： | 1 |
| 19 | The expressoion of products of oncogene c-erbB2 and EGFR and proliferating antigens Ki67 and PCNA in primary invasive ductal cancer of female breast显示文摘 | Jeziorski A Blonski J Z Niewiadomska H | 2000 | J Exp Clin Cancer Res2000，19，1： | 1 |
| 20 | Supportive care in neu- rooncology显示文摘 | Taillandier L Blonski M Darlix A | 2011 | Rev Neurol (Paris)2011，167，10： | 1 |
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