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| 1 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 2 | Superparamagnetic clustering of data显示文摘 | BLATT M WISEMAN S DOMANY E | 1996 | Phys Rev Lett1996，76，： | 1 |
| 3 | Data Clustering Using a Model Granular Magnet显示文摘 | BLATT M WISEMAN S DOMANY E | 1997 | Neural Computation1997，9，： | 1 |
| 4 | Basal core promoter T1762/ A1764 and precore A 1896 gene mutations in hepatitis B surface antigen - positive hepatocellular carcinoma: a comparison with chronic carriers 显示文摘 | Tong M J Blatt L M Kao J H | 2007 | Liver Int2007，27，10： | 1 |
| 5 | Modulation of K+ channels in Vicia stomatal guard cells by peptide homologs to the auxing-binding protein C terminus显示文摘 | Blatt Mr Fricker M D | 1993 | Proc Natl Acad Sci USA1993，90，11： | 1 |
| 6 | Role of prothrombin complex concentrates in re- versing warfarin anticoagulation: a review of the lit- erature显示文摘 | LEISSINGER C A BLATT P M HOOTS W K | 2008 | Am J Hematol2008，83，： | 1 |
| 7 | Functional conservation between yeast and plant endosomal Na+/H+ antiporter显示文摘 | Quintero F J Blatt M R Pardo J M | 2000 | FEBS Lett2000，47，1： | 1 |
| 8 | Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidativestress显示文摘 | Chandrasekharan B Anitha M Blatt R | 2011 | Neurogastroenterol Motil2011，23，13： | 1 |
| 9 | Microbial growth inhibition by alternating electric fields显示文摘 | GILADI M PORAT Y BLATT A | 2008 | Antimicrob Agents Chemotherapy2008，52，10： | 1 |
| 10 | Global water resources: vulnerability from climate change and population growth显示文摘 | Turton A R Mood ley S Gold blatt M | 2002 | Science2002，289，： | 1 |
| 11 | Nuclease resistant synthetic ribozymes:developing a new class of therapeutics显示文摘 | Usman N Blatt L M | 2000 | J Clin Invest2000，106，10： | 1 |
| 12 | Prediction of response during interferon alfa 2b therapy in chronic hepatitis C patients using viral and biochemical characteristics:a comparison显示文摘 | Tong M J Blatt LM McHutchison JG Co RL Courad A | | Hepatology0，，： | 1 |
| 13 | Robotic partial nephreetomy for complex renal tumors: surgical technique显示文摘 | Rogers C G Singh A Blatt A M Linehan W M Pinto P A | 2008 | Eur Urol2008，53，： | 1 |
| 14 | Evaluating the reliability of automated collision notification systems显示文摘 | Mohan R Akella Chaewon Bang Rob Beutner Eric M Delmelle Rajan Batta Alan Blatt Peter A Rogerson Glenn Wilson | 2002 | Accident Analysis and Prevention2002，，3： | 1 |
| 15 | The biologic activity and molecular characterization of a novel synthetic interferon-alpha species, consensus interferon显示文摘 | Blatt L M Davis J M Klein S B | 1996 | Journal of International Cytometry Research1996，16，： | 1 |
| 16 | Microbial growth inhibition by alternating electric fields in mice with Pseudomonas aeruginosa lung infection显示文摘 | GILADI M PORAT Y BLATT A | 2010 | Antimicrobial Agents and Chemotherapy2010，54，8： | 1 |
| 17 | Ca2+ signaling and control of guard-cell volume in stomatal movements 显示文摘 | Blatt M R | 2000 | Current Opinion in Plant Biology2000，3，3： | 1 |
| 18 | A potassium-proton symport in Neurospora crassa显示文摘 | Rodriguez-Navarro A Blatt M R Slayman C L | 1986 | The Journal of General Physiology1986，87，： | 1 |
| 19 | Robotic partial nephree- tomy for renal hilar tumors:a multi-institutional analy- sis显示文摘 | Rogers C G Metwalli A Blatt A M Bratslavsky G Menon M Linehan W M | 2008 | J Urol2008，180，： | 1 |
| 20 | Functional conservation between Yeast and plant endosomal Na^+/H^+ antiporters显示文摘 | Quintero F J Blatt M R Pardo J M | 2000 | FEBS Lett2000，471，： | 1 |
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