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| 1 | Endothelial adhesion of synchronized gastric tumor cells changes during cell cycle transit and correlates with the expression level of CD44 splice variants显示文摘AIM: To study adhesion capacity and CD44 expression of human gastric adenocarcinoma MKN45 cells at different stages of a first cell cycle.METHODS: MKN45 cells were synchronized by aphidicolin and assayed for adhesion to an endothelial cell (HUVEC)monolayer. Surface expression of CD44 and CD44 splice variants on MKN45 cells was evaluated by flow cytometry.Functional relevance of CD44 adhesion receptors was investigated by blocking studies using anti CD44 monoclonal antibodies or by hyaluronan digestion.RESULTS: Adhesion of MKN45 to HUVEC was increased during G2/M transit, after which adhesion returned to baseline levels with cell cycle completion. In parallel, CD44splice variants CD44v4, CD44v5, and CD44v7 were all upregulated on MKN45 during cell cycle progression with a maximum effect in G2/M. The function of CD44 surface receptors was assessed with specific receptor blocking monodonal antibodies or removal of hyaluronan by digestion with hyaluronidase. Both strategies inhibited tumor cell adhesion to HUVEC by nearly 50%, which indicates that MKN45-HUVEC-interaction is CD44 dependent.CONCLUSION: CD44 expression level is linked to the cell cycle in gastrointestinal tumor cells, which in turn leads to cell cyde dependent alterations of their adhesion behaviour to endothelium. | Anton Oertl Jens Castein Tobias Engl Wolf-Dietrich Beecken Dietger Jonas Richard Melamed Roman A. Blaheta | 2005 | World Journal of Gastroenterology2005，11，40： | 3 |
| 2 | Anti-tumor mechanisms of valproate: a novel role for an old drug显示文摘 | Blaheta R A Cinatl Jr J | 2002 | Med Res Rev2002，22，5： | 1 |
| 3 | Induction of differentiation and suppression of malignant phenotype of human neuroblastoma BE (2)-C cells by valproic acid: enhancement by combination with interferon-alpha 显示文摘 | Cinatl J Jr Kotchetkov R Blaheta R | 2002 | Int J Oncol2002，20，1： | 1 |
| 4 | Anti-tumor mechanisms of valproate: a novel role for an old drut显示文摘 | Blaheta RA | 2002 | Med Res Rev2002，22，5： | 1 |
| 5 | Evolving antican- cer drug valproic acid:insights into the mechanism and clinical studies显示文摘 | Blaheta R A Michaelis M Driever P H | 2005 | Med Rev2005，25，4： | 1 |
| 6 | Inhibition of endothelial receptor expression and of T cell ligand actLMity by mycophenolate mofetil显示文摘 | Leckel K Wittig B | 1998 | Transplant Immunol1998，6，： | 1 |
| 7 | Analysis of sp Pillar Stability Experiment: Continuous thermo-mechanical model development and calibration显示文摘The paper describes an analysis of thermo-mechanical (TM) processes appearing during the sp Pillar Stability Experiment (APSE). This analysis is based on finite elements with elasticity, plasticity and damage mechanics models of rock behaviour and some least squares calibration techniques. The main aim is to examine the capability of continuous mechanics models to predict brittle damage behaviour of granite rocks. The performed simulations use an in-house finite element software GEM and self-developed experimental continuum damage MATLAB code. The main contributions are twofold. First, it is an inverse analysis, which is used for (1) verification of an initial stress measurement by back analysis of convergence measurement during construction of the access tunnel and (2) identification of heat transfer rock mass properties by an inverse method based on the known heat sources and temperature measurements. Second, three different hierarchically built models are used to estimate the pillar damage zones, i.e. elastic model with Drucker-Prager strength criterion, elasto-plastic model with the same yield limit and a combination of elasto-plasticity with continuum damage mechanics. The damage mechanics model is also used to simulate uniaxial and triaxial compressive strength tests on the spgranite. | R. Blaheta P. Byczanski M. ermák R. Hrtus R. Kohut A. Kolcun J. Malík S. Sysala | 2013 | Journal of Rock Mechanics and Geotechnical Engineering2013，5，2： | 1 |
| 8 | Interleukin-4, interleukin-10, and interleukin-1-receptor antagonist but not transforming growth factor-beta induce ramification and reduce adhesion molecule expression of rat microglial cells显示文摘 | Wirjatijasa F Dehghani F Blaheta R A | 2002 | J Neurosci Res2002，68，5： | 1 |
| 9 | Induction of differentiation and suppression of malignant phenotype of human neuroblastoma BE (2)-C cells by valproic acid: enhancement by combination with interferon显示文摘 | Cinatl Jr J Kotchetkov R Blaheta R | 2002 | Int J Oncol2002，20，3： | 1 |
| 10 | inhibition of endothelial receptor expression and of Tcell ligand activity by mycophenolate mofetlil 显示文摘 | Blaheta RA Leckel K Wittig B | 1998 | Transplant Immunol1998，6，2： | 1 |
| 11 | Induction of differentiation and suppression of malignant phenotype of human neuroblastoma BE (2)-C cells by valproic acid: enhancement by combination with interferon-alpha 显示文摘 | Cinatl J Jr Kotchetkov R Blaheta R | 2002 | Int J Oncol2002，20，1： | 1 |
| 12 | Evolving anticancer drug valproic acid:insights into the mechanism and clinical studies 显示文摘 | Blaheta RA Michaelis M Driever PH | 2005 | Med Res Rev2005，25，4： | 1 |
| 13 | Inhibition of monocyte/endothelial cell interactions and monocyte adhesion molecule expression by the immunosuppressant mycophenolate mofetil显示文摘 | Glomsda BA Blaheta RA Hailer NP | 2003 | Spinal Cord2003，41，11： | 1 |
| 14 | State of hepatocyte transplantation:A risk or a chance?显示文摘 | Leckel K Blaheta RA Markus BH | 2003 | Zentralbl Chir2003，128，： | 1 |
| 15 | In vitro analysis of verapamil - induced immunosuppression : potent inhibition of T cell motility and lymphocytic transmigration through allogeneic endothelial cells显示文摘 | Blaheta RA Hailer NP Brudc N | 2000 | Transplantation2000，69，4： | 1 |
| 16 | Mycophenolate mofetil impairs transendothelial migration of allogeneic CD4 and CD8 T- cells显示文摘 | Blaheta RA Leckel K Wittig B | 1999 | Transplant Proc1999，31，2： | 1 |
| 17 | Robotic-Assisted Laparoscopic Radical Cystectomy and Intra-Abdominal Formation of an Orthotopic Ileal Neobladder显示文摘 | W.-D. Beecken M. Wolfram T. Engl W. Bentas M. Probst R. Blaheta A. Oertl D. Jonas J. Binder | 2003 | European Urology2003，，： | 1 |
| 18 | Inhibition ofendothelial receptor expression and of T-cell ligand activityby mycophenolate mofetil显示文摘 | Blaheta RA Lechel K Wittig B | 1998 | Transpl Immunol1998，6，4： | 1 |
| 19 | Interleukin- 4,inter- leukin-lO,and interleukin- 1- receptor antagonist but not trans- forming growth factor- beta induce ramification and reduce adhesion- molecule expression of rat microglial cells 显示文摘 | Wirjatijasa F Dehghani F Blaheta R A | 2002 | J Neurosci Res2002，68，5： | 1 |
| 20 | Transitional cell carcinoma of the native urinary tract after kidney transplantation : recommenda- tions following a long-term retrospective analysis 显示文摘 | Tsaur I Karalis A Blaheta R | 2011 | Am J Med Sci2011，341，6： | 1 |
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