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| 1 | Colon cancer and the epidermal growth factor receptor:Current treatment paradigms,the importance of diet,and the role of chemoprevention显示文摘Colorectal cancer represents the third most common and the second deadliest type of cancer for both men and women in the United States claiming over 50000 lives in 2014. The 5-year survival rate for patients diagnosed with metastatic colon and rectal cancer is < 15%. Early detection and more effective treatments are urgently needed to reduce morbidity and mortality of patients afflicted with this disease. Here we will review the risk factors and current treatment paradigms for colorectal cancer, with an emphasis on the role of chemoprevention as they relate to epidermal growth factor receptor(EGFR) blockade. We will discuss how various EGFR ligands are upregulated in the presence of Western diets high in saturated and N-6 polyunsaturated fats. We will also outline the various mechanisms of EGFR inhibition that are induced by naturally occurring chemopreventative agents such as ginseng, green tea, and curcumin. Finally, we will discuss the current role of targeted chemotherapy in colon cancer and outline the limitations of our current treatment options, describing mechanisms of resistance and escape. | Baldeep Pabla Marc Bissonnette Vani J Konda | 2015 | World Journal of Clinical Oncology2015，6，5： | 7 |
| 2 | Usefulness of endoscopic ultrasonography in hepatology显示文摘 | Bissonnette J Paquin S Sahai A | | 0，，11： | 1 |
| 3 | Capnometry and the paediatric laryngeal mask airway 显示文摘 | Spahr-Schopfer I A Bissonnette B Hartley E J | 1993 | Can J Anesth1993，40，5： | 1 |
| 4 | Quality assurance for image-guided radiation therapy utilizing CT-based technologies:A report of the AAPM TG-179显示文摘 | Bissonnette J P Baiter P A Dong L | 2012 | Med Phys2012，39，4： | 1 |
| 5 | Modified natural-cycle in vitro fertilization should be considered as the first approach in young poor responders 显示文摘 | Kadoch I J Phillips S J Bissonnette F | 2011 | Fertil Steri12011，96，5： | 1 |
| 6 | The long-term outcome of microvaseular decompression for lrigeminal neuralgia 显示文摘 | Barker FG Janetta P J Bissonnette D J | 1996 | New England Journal of Med cine1996，334，4： | 1 |
| 7 | Duchenne muscular dystrophy: An old anesthesia problem revisited显示文摘 | Hayes J Veyckemans F Bissonnette B | 2008 | Paediatr Anaesth2008，18，2： | 1 |
| 8 | Acute intermittent hypoxia-induced expression brain-derived neurotrophic factor is disrupted the brainstem of methyl-CpG-binding protein 2 null mice显示文摘 | Vermehren-Schmaedick A Jenkins V K Knopp S J Balkowiec A Bissonnette J M | | 0，，： | 1 |
| 9 | Improved modeling of atom-molecule potential-energy surfaces: Illustrative application to He-CO 显示文摘 | LeRoy R J Bissonnette Wu C T | 1994 | Faraday Discuss1994，97，： | 1 |
| 10 | Fibro- blast growth factor-2 is a sputum remodeling hiomarker of severe asthma 显示文摘 | BISSONNETTE I: MADORE A M CHAKIR J | 2014 | Journal of Asthma2014，51，2： | 1 |
| 11 | Respiration correlated cone-beam computed tomography and 4DCT for evaluating target motion in stereotactic lung radiation therapy 显示文摘 | Purdie TG Moseley D J Bissonnette JP | 2006 | Acta Oncol2006，45，7： | 1 |
| 12 | Fate of physical,chemical and microbial contaminants in domestic wastewater following treatment by small constructed wetlands显示文摘 | Keith R Hench Gary K Bissonnette Alan J Sexstone | 2003 | Wat Res2003，，37： | 1 |
| 13 | Fate of physical, chemical, and microbial contaminants in do- mestic waste water following treatment by small construc- ted wetlands 显示文摘 | Hencha K R Bissonnette G K Sexstone A J | 2003 | Water Research2003，37，： | 1 |
| 14 | Sper-matozoal transcriptome profiling for bull sperm motility : a poten-tial tool to evaluate semen quality显示文摘 | Bissonnette N Levesque-Sergerie J P Thibault C | 2009 | Reproduction2009，138，： | 1 |
| 15 | Usefulness of endoscopic ultrasonography in hepatology显示文摘 | Bissonnette J Paquin S Sahai A | 2011 | Can J Gastroenterol2011，25，11： | 1 |
| 16 | Capnometry and the paediatrie laryngeal mask airway 显示文摘 | SPAHR-SCHOPFER I A BISSONNETTE B HARTLEY E J | 1993 | CanJ Anaesth1993，40，11： | 1 |
| 17 | Thermal regulation and mild intraoperative hypothermia显示文摘 | Davis A J Bissonnette B | 1999 | Current Opinion in Anaesthesiology1999，12，3： | 1 |
| 18 | Topical photodynamic therapy with 5-aminolaevulinic acid does not induce hair regrowth in patients with extensive alopecia areata显示文摘 | Bissonnette R Shapiro J Zeng H | 2000 | Br J Dermatol2000，143，5： | 1 |
| 19 | Intrinsic, extrinsic, andmotivationalstylesaspredi cators of behavior:A prospective study显示文摘 | Vallerand R J Bissonnett R | 1992 | Journal of Personality and Social Psychology1992，60，： | 1 |
| 20 | Fate of physical, chem- ical, and microbial contaminants in domestic wastewater following treatment by small constructed wetlands显示文摘 | Hench K R Bissonnette G K Sexstone A J | 2003 | Water Res2003，37，： | 1 |
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