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| 1 | Altered trends in carbon uptake in China’s terrestrial ecosystems under the enhanced summer monsoon and warming hiatus显示文摘The carbon budgets in terrestrial ecosystems in China are strongly coupled with climate changes.Over the past decade,China has experienced dramatic climate changes characterized by enhanced summer monsoon and decelerated warming.However,the changes in the trends of terrestrial net ecosystem production(NEP)in China under climate changes are not well documented.Here,we used three ecosystem models to simulate the spatiotemporal variations in China's NEP during 1982–2010 and quantify the contribution of the strengthened summer monsoon and warming hiatus to the NEP variations in four distinct climatic regions of the country.Our results revealed a decadal-scale shift in NEP from a downtrend of–5.95 Tg C/yr^2(reduced sink)during 1982–2000 to an uptrend of 14.22 Tg C/yr^2(enhanced sink)during 2000–10.This shift was essentially induced by the strengthened summer monsoon,which stimulated carbon uptake,and the warming hiatus,which lessened the decrease in the NEP trend.Compared to the contribution of 56.3%by the climate effect,atmospheric CO2 concentration and nitrogen deposition had relatively small contributions(8.6 and 11.3%,respectively)to the shift.In conclusion,within the context of the global-warming hiatus,the strengthening of the summer monsoon is a critical climate factor that enhances carbon uptake in China due to the asymmetric response of photosynthesis and respiration.Our study not only revealed the shift in ecosystem carbon sequestration in China in recent decades,but also provides some insight for understanding ecosystem carbon dynamics in other monsoonal areas. | Honglin He Shaoqiang Wang Li Zhang Junbang Wang Xiaoli Ren Lei Zhou Shilong Piao Hao Yan Weimin Ju Fengxue Gu Shiyong Yu Yuanhe Yang Miaomiao Wang Zhongen Niu Rcmg Ge Huimin Yan Mei Huang Guoyi Zhou Yongfei Bai Zongqiang Xie Zhiyao Tang Bingfang Wu Leiming Zhang Nianpeng He Qiufeng Wang Guirui Yu | 2019 | National Science Review2019，6，3： | 24 |
| 2 | Progress in transdermal drug delivery systems for cancer therapy显示文摘Transdermal drug delivery is an appealing option except for oral and hypodermic administration.With the advancement of skin penetration strategies,various anticancer therapeutics ranging from liphilic small-molecule drugs to hydrophilic biomacromolecules,can be administered transdermally,offering an optional regimen to treat skin cancers.In addition,the activation of the skin immune systems can also assist the treatment of distal sites.Current approaches on enhancing the transdermal delivery efficacy of anticancer drugs are summarized in this review.We also survey recent advances in micro-and nanotechnology-based transdermal formulations for cancer treatment,such as chemotherapy,gene therapy,immunotherapy,phototherapy and combination therapy.New penetration enhancers,materials,formulations and their hypothesized mechanisms for transdermal delivery are highlighted.Advantages and limitations regarding the state-of-the-art transdermal delivery technologies,as well as future perspective are also discussed. | Tianyue Jiang Guo Xu Guojun Chen Yu Zheng Bingfang He Zhen Gu | 2020 | Nano Research2020，13，7： | 5 |
| 3 | Plating osteosynthesis of mid-distal humeral shaft fractures: minimally invasive versus conventional open reduction technique显示文摘 | Zhiquan An Bingfang Zeng Xiaojian He Qi Chen Shundong Hu | 2010 | International Orthopaedics2010，，1： | 1 |
| 4 | Direct stamping multifunctional tactile sensor for pressure and temperature sensing显示文摘Flexible and wearable sensors have broad application prospects in health monitoring and artificial intelligence.Many different single-functional sensing devices have been developed in recent years,such as pressure sensors and temperature sensors.However,it is still a great challenge to design and fabricate tactile sensors with multiple sensing functions.Herein,we propose a simple direct stamping method for the fabrication of multifunctional tactile sensors.It can detect pressure and temperature stimuli signals simultaneously.This pressure/temperature sensor possesses high sensitivity(0.67 kPa^(-1)),large linear range(0.75-5 kPa),and fast response speed(15.6 ms)in pressure sensing.It also has a high temperature sensitivity(1.41%/℃)and great linearity(0.99)for temperature sensing in the range of-30 to 30℃.All these excellent performances indicate that this pressure/temperature sensor has great potential in applications for artificial intelligence and health monitoring. | Binghao Liang Bingfang Huang Junkai He Rongliang Yang Chengchun Zhao Bo-Ru Yang Anyuan Cao Zikang Tang Xuchun Gui | 2022 | Nano Research2022，15，4： | 1 |
| 5 | Plating osteosynthesis of mid-distal humeral shaft fractures: minimally invasive versus conventional open reduction technique显示文摘 | Zhiquan An Bingfang Zeng Xiaojian He Qi Chen Shundong Hu | 2010 | International Orthopaedics2010，，1： | 1 |
| 6 | Emerging prospects of protein/peptide-based nanoassemblies for drug delivery and vaccine development显示文摘Proteins have been widely used in the biomedical field because of their well-defined architecture,accurate molecular weight,excellent biocompatibility and biodegradability,and easy-to-functionalization.Inspired by the wisdom of nature,increasing proteins/peptides that possess self-assembling capabilities have been explored and designed to generate nanoassemblies with unique structure and function,including spatially organized conformation,passive and active targeting,stimuli-responsiveness,and high stability.These characteristics make protein/peptide-based nanoassembly an ideal platform for drug delivery and vaccine development.In this review,we focus on recent advances in subsistent protein/peptide-based nanoassemblies,including protein nanocages,virus-like particles,self-assemblable natural proteins,and self-assemblable artificial peptides.The origin and characteristics of various protein/peptide-based assemblies and their applications in drug delivery and vaccine development are summarized.In the end,the prospects and challenges are discussed for the further development of protein/peptide-based nanoassemblies. | Taiyu Liu Lu Li Cheng Cheng Bingfang He Tianyue Jiang | 2022 | Nano Research2022，15，8： | 0 |
| 7 | Meta photonic crystal paper devices显示文摘With its unique properties of thin,porous,flexible and affordable,paper has been widely used as a multifunctional material in daily life since its invention[1].Commonly,paper is the most popular carrier for information transmission such as writing and printing.However,since the applications of paper has been broadened continuously,it has also shown great prospect in the field of biochemical ana・lysis.Paper-based analytical devices are easy to use,low cost,portable and disposable,thus playing an important role in the field of rapid detection[2]. | GUO MaoZe WANG YuQiu HE BingFang GAO BingBing | 2020 | Science China(Technological Sciences)2020，63，11： | 0 |
| 8 | Emerging electrochemical sensors for life healthcare显示文摘As electrochemical sensors possess unique potential properties that are strongly related to their high sensitiv-ity,selectivity and cycling stability,making it extensively used in versatile fields of biosensing,electrochemical analysis and drug delivery.Notably,recent evidence demonstrates that electrochemical technology provides a promising platform for life healthcare by biocompatibility of mimicking human tissue to report electrical signals,potentially enabling timely disorder prediction through non-invasive real time and simultaneous health monitoring.This review focuses on the comprehensive set of advances in the field of electrochemical devices for life healthcare,including fabrication,analytical performance,and their multiple applications in clinical settings are deliberated. | Huihui Lu Bingfang He Bingbing Gao | 2021 | Engineered Regeneration2021，2，1： | 0 |
| 9 | The lasso structure,biosynthesis,bioactivities and potential applications of Microcin J25:A novel antibacterial agent with unique mechanisms显示文摘The overuse and misuse of traditional antimicrobial drugs have led to their weakened effectiveness and the emergence of pathogenic bacterial resistance.Consequently,there has been growing interest in alternative op-tions such as antimicrobial peptides(AMPs)in the pharmaceutical industry.Microcin J25(MccJ25)has gained significant attention for its potent inhibitory effect on a diverse range of pathogens.Its unique rotaxane structure provides exceptional stability against extreme thermal,pH,and protease degradation,including chymotrypsin,trypsin,and pepsin.Given its remarkable stability and diverse bioactivity,we aim to provide an overview of the physicochemical properties,the mechanism underlying its antimicrobial activity,and the critical functional residues of MccJ25.Additionally,we have summarized the latest strategies for the heterologous expression of MccJ25,and its potential medical use and other applications. | Qingchun Ji Bixia Zhou Tong Shen Tianyue Jiang Cheng Cheng Bingfang He | 2023 | Engineering Microbiology2023，3，3： | 0 |
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