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| 1 | Identification of four novel DC-SIGN ligands on Mycobacterium bovis BCG显示文摘Dendritic-cell-specific intercellular adhesion molecule-3-grabbing non-integrin(DC-SIGN;CD209)has an important role in mediating adherence of Mycobacteria species,including M.tuberculosis and M.bovis BCG to human dendritic cells and macrophages,in which these bacteria can survive intracellularly.DC-SIGN is a C-type lectin,and interactions with mycobacterial cells are believed to occur via mannosylated structures on the mycobacterial surface.Recent studies suggest more varied modes of binding to multiple mycobacterial ligands.Here we identify,by affinity chromatography and mass-spectrometry,four novel ligands of M.bovis BCG that bind to DC-SIGN.The novel ligands are chaperone protein DnaK,60 kDa chaperonin-1(Cpn60.1),glyceraldehyde-3 phosphate dehydrogenase(GAPDH)and lipoprotein lprG.Other published work strongly suggests that these are on the cell surface.Of these ligands,lprG appears to bind DC-SIGN via typical proteinglycan interactions,but DnaK and Cpn60.1 binding do not show evidence of carbohydrate-dependent interactions.LprG was also identified as a ligand for DC-SIGNR(L-SIGN;CD299)and the M.tuberculosis orthologue of lprG has been found previously to interact with human toll-like receptor 2.Collectively,these findings offer new targets for combating mycobacterial adhesion and within-host survival,and reinforce the role of DCSIGN as an important host ligand in mycobacterial infection. | Maria V.Carroll Robert B.Sim Fabiana Bigi Anne Jäkel Robin Antrobus Daniel A.Mitchell | 2010 | Protein & Cell2010，1，9： | 7 |
| 2 | The effect of zoledronate-hydroxyapatite nanocomposites on osteoclasts and osteoblast-like cells in vitro显示文摘 | Elisa Boanini Paola Torricelli Massimo Gazzano Milena Fini Adriana Bigi | 2011 | Biomaterials2011，，2： | 2 |
| 3 | Thrombus aspiration before primary angioplasty improves myocardial reperfusion in acute myocardial infarction : the DEAR-MI ( Dethrombosis to Enhance Acute Reperfusion in Myocardial Infarction) study 显示文摘 | Silva-Orrego P Colombo P Bigi R | 2006 | J Am Coll Cardiol2006，48，8： | 1 |
| 4 | Characterization of P55, a multidrug efflux pump in Mycobacterium boris and Mycobacteritun tuberculosis 显示文摘 | Silva PE A Bigi F Ainsa JA | 2001 | Antimicrobial Agents and Chemotherapy2001，45，3： | 1 |
| 5 | Isola- tion and mapping of two porcine skeletal muscle myo- sin heavy chain isoforms 显示文摘 | DAVOLI R ZAMBONELLI P BIGI D | 1998 | Anita Genet1998，29，2： | 1 |
| 6 | Calcium phosphate thin films synthesized by pulsed laser deposition:Physico-chemical characterization and in vitro cell response 显示文摘 | Mihailescu I N Torricelli P Bigi A | 2005 | Applied Surface Science2005，248，34： | 1 |
| 7 | A novel synthetic route to all- ortho novolac resins 显示文摘 | G Casiraghi G Sartori F Bigi | 1981 | Makromol Chem1981，182，： | 1 |
| 8 | Thrombus aspiration before standardprimary angioplasty improves myocardial reperfusion in acute myocardialinfarction:The DEAR-MI(De thrombosis to Enhance Acute Reperfusionin Myocardial Infarction)Study显示文摘 | Orrego PS Colombo P Bigi R | 2006 | J Am Coll Cardiol2006，48，8： | 1 |
| 9 | Relationship belween triple- helix content and mechanical properties of gelatin films 显示文摘 | Bigi A Panzavoha S Rubini K | 2004 | Bioma|erials2004，25，25： | 1 |
| 10 | Chemical and structural characterization of the mineral hase from cortical and trabecular bone显示文摘 | Bigi A Cojazzi G Panzavolta S | 1997 | Inorganic Biochemistry1997，68，1： | 1 |
| 11 | Effect of ex- treme exercise on myocardial function as assessed by tissue doppler imaging显示文摘 | Aslani A Babaee Bigi MA Moaref AR | 2009 | Echocardiography2009，26，9： | 1 |
| 12 | Clean synthesis in water part 2:Uncatalysed condensation reaction of Meldrum's acid and aldehydes 显示文摘 | Carloni S Ferrari L | 2001 | Tetrahedron Lett2001，42，31： | 1 |
| 13 | 药物负荷超声心动图在已知或疑似冠状动脉疾病的糖尿病及非糖尿病患者中的预后价值显示文摘OBJECTIVES: We sought to compare the prognostic value of pharmacological stress echocardiography(SE) in diabetic and nondiabetic patients with known or suspected coronary artery disease. BACKGROUND: Although SE is a useful tool for risk stratification of patients with diabetes, it has not been established whether it retains the same prognostic information in diabetic patients compared with nondiabetic patients. METHODS: A total of 5,456 patients(749 diabetics) undergoing dipyridamole(n=3,306) or dobutamine(n=2,150) SE were prospectively followed up for the occurrence of hard events(death and/or nonfatal myocardial infarction). RESULTS: During a median time of 31 months, 411 deaths and 236 infarctions occurred. There were 132 events in diabetic patients and 515 in nondiabetic patients(18% vs. 11% , respectively; p< 0.0001). Moreover, 1,607(29% ) patients underwent coronary revascularization and were censored. Ischemia at SE, resting wall motion score index, and age were independent predictors of death and hard events in both diabetic and nondiabetic patients. Compared with a normal test, ischemia and scar test patterns were associated to significantly lower age- corrected five- year hard event- free survival in diabetic as well as nondiabetic patients. However, a normal test was associated with a greater than two- fold annual event rate in diabetic patients as compared with nondiabetics who were either younger(2.6% vs. 1.0% ) or older(5.5% vs. 2.2% ) than 65 years of age. CONCLUSIONS: Stress echocardiographyis equally effective in risk stratifying diabetic and nondiabetic patients independently of age. However, the normal test result predicts a less favorable outcome in diabetic than in nondiabetic patients. | Cortigiani L. Bigi R. Sicari R. 张宪伟 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，6： | 1 |
| 14 | Twisted plywood pattern of collagen fibrils in teleost scales: an x-ray diffraction investigation 显示文摘 | BIGI A BURGHAMMER M FALCONI R | 2001 | Journal of Structural Biology2001，136，2： | 1 |
| 15 | Emergency laparoscopic splenectomy for haemoperitoneum because of ruptured primary splenic pregnancy: a case report and review of literature 显示文摘 | Biolchini F Giunta A Bigi L Bertellini C | 2010 | ANZJSurg2010，80，12： | 1 |
| 16 | Thrombus aspiration before primary angioplasty improves myocardial reperfusion in acute myocardial infarction:the DEAR-MI (Dethrombosis to Enhance Acute Reperfusion in Myocardial Infarc- tion) study显示文摘 | Silva-Orrego P Colombo P Bigi R | 2006 | J Am Coil Cardiol2006，48，8： | 1 |
| 17 | aVR sign as a risk factor for life-threatening arrhythmic events in patients with Brugada syndrome显示文摘 | Mohamad Ali Babai Bigi Amir Aslani Shahab Shahrzad | 2007 | Heart Rhythm2007，，8： | 1 |
| 18 | Stabilization of gelatin films by Crosslinking with genipin 显示文摘 | Bigi A Cojazzi G Panzavolta S | 2002 | Biomaterials2002，23，24： | 1 |
| 19 | Heterogeneous enantioselective epoxidation of olefins catalysed by unsymmetrical(salen)Mn(Ⅲ) complexes supported on amorphous or MCM-41 silica through a new triazine-based linker显示文摘 | Bigi F Franca B Moroni L | 2002 | J Chem Soc Chem Commun2002，，7： | 1 |
| 20 | Mechanical and thermal properties of gelatin films at different degrees of glutaraldehyde crosslinking显示文摘 | Bigi A Cojazzi G Panzavolta S | 2001 | Biomaterials2001，22，8： | 1 |
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