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| 1 | The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types显示文摘The Genome Sequence Archive(GSA)is a data repository for archiving raw sequence data,which provides data storage and sharing services for worldwide scientific communities.Considering explosive data growth with diverse data types,here we present the GSA family by expanding into a set of resources for raw data archive with different purposes,namely,GSA(http://gffzz77e3413bc06540eds95uucp6uxcb66wfp.ffgz.tsg.suse.edu.cn/gsa/),GSA for Human(GSA-Human,http://gffzz77e3413bc06540eds95uucp6uxcb66wfp.ffgz.tsg.suse.edu.cn/gsa-human/),and Open Archive for Miscellaneous Data(OMIX,http://gffzz77e3413bc06540eds95uucp6uxcb66wfp.ffgz.tsg.suse.edu.cn/omix/).Compared with the 2017 version,GSA has been significantly updated in data model,online functionalities,and web interfaces.GSA-Human,as a new partner of GSA,is a data repository specialized in human genetics-related data with controlled access and security.OMIX,as a critical complement to the two resources mentioned above,is an open archive for miscellaneous data.Together,all these resources form a family of resources dedicated to archiving explosive data with diverse types,accepting data submissions from all over the world,and providing free open access to all publicly available data in support of worldwide research activities. | Tingting Chen Xu Chen Sisi Zhang Junwei Zhu Bixia Tang Anke Wang Lili Dong Zhewen Zhang Caixia Yu Yanling Sun Lianjiang Chi Huanxin Chen Shuang Zhai Yubin Sun Li Lan Xin Zhang Jingfa Xiao Yiming Bao Yanqing Wang Zhang Zhang Wenming Zhao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 38 |
| 2 | GSA:Genome Sequence Archive显示文摘With the rapid development of sequencing technologies towards higher throughput and lower cost, sequence data are generated at an unprecedentedly explosive rate. To provide an efficient and easy-to-use platform for managing huge sequence data, here we present Genome Sequence Archive(GSA; http://gffzzdbc7b6aaae734bddh95uucp6uxcb66wfp.ffgz.tsg.suse.edu.cn/gsa or http://gffzz4eaf941a184140e3h95uucp6uxcb66wfp.ffgz.tsg.suse.edu.cn), a data repository for archiving raw sequence data. In compliance with data standards and structures of the International Nucleotide Sequence Database Collaboration(INSDC), GSA adopts four data objects(Bio Project, Bio Sample,Experiment, and Run) for data organization, accepts raw sequence reads produced by a variety of sequencing platforms, stores both sequence reads and metadata submitted from all over the world,and makes all these data publicly available to worldwide scientific communities. In the era of big data, GSA is not only an important complement to existing INSDC members by alleviating the increasing burdens of handling sequence data deluge, but also takes the significant responsibility for global big data archive and provides free unrestricted access to all publicly available data in support of research activities throughout the world. | Yanqing Wang Fuhai Song Junwei Zhu Sisi Zhang Yadong Yang Tingting Chen Bixia Tang Lili Dong Nan Ding Qian Zhang Zhouxian Bai Xunong Dong Huanxin Chen Mingyuan Sun Shuang Zhai Yubin Sun Lei Yu Li Lan Jingfa Xiao Xiangdong Fang Hongxing Lei Zhang Zhang Wenming Zhao | 2017 | Genomics, Proteomics & Bioinformatics2017，15，1： | 13 |
| 3 | Prevalence and treatment of hypertension in China: impacts of 2017 American College of Cardiology/American Heart Association High Blood Pressure Guideline显示文摘The definition, recommended treatment thresholds and targets of hypertension have been updated in the recent 2017 American College of Cardiology/American Heart Association(ACC/AHA) Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults. However,the impacts of this guideline on Chinese population are currently unknown. In this study, we aim to provide updated data in China using criteria from the updated guideline. A multistage, stratified sampling method was used to obtain a representative sample of 50,171 adults aged 18 years and above.Hypertension was defined as an average systolic blood pressure !130 mm Hg, or an average diastolic blood pressure !80 mm Hg, or self-reported use of antihypertensive medications in past 2 weeks. The weighted prevalence of hypertension was 60.1%(95% confidence interval [CI] 59.3%–61.0%). The treatment rate and recommended treatment rate were 16.8%(95% CI 16.1%–17.6%) and 53.7%(95% CI52.6%–54.9%), respectively; the gap was more prominent among men and participants from rural areas.Hence, the adoption of the 2017 ACC/AHA guideline will lead to a substantial increase in both prevalence and number of patients needing treatment in China. The applicability of this guideline should be carefully evaluated based on evidence from Chinese population. | Chao Yang Jinwei Wang Bixia Gao Yan Zhang Fang Wang Luxia Zhang Minghui Zhao Yong Huo | 2018 | Science Bulletin2018，63，8： | 7 |
| 4 | Tourist preferences for agricultural landscapes:a case study of terraced paddy fields in Noto Peninsula,Japan显示文摘Many agricultural landscapes have been formed through the interaction and co-evolution of nature and people, and represent the living landscapes shaped over time through intensive and continuous human cultivation. Terraced paddy fields are being re-evaluated to take into account the multiple functions they fill beyond only rice cultivation, particularly their contribution to the national biodiversity strategy of Japan. Since the 1990 s, terraced paddy fields have been considered a representative cultural landscape of Japan and, at the same time, multi-stakeholder conservation activities have been conducted throughout Japan to reverse the increasing abandonment of terraces. Shiroyone Senmaida is an outstanding cultural landscape and a major tourist attraction in Noto Peninsula, Ishikawa Prefecture, which was designated through an initiative by the Food and Agriculture Organization(FAO) as a Globally Important Agricultural Heritage Systems(GIAHS) pilot site in 2011. It is important to clarify tourist preference for terraced paddy field landscapes to contribute to future policy making toward improved agricultural landscape conservation. A key finding of this study is that tourists visiting toenjoy the agricultural landscape are also concerned on the sustainability of the farming methods and preferred to maintain the naturalness of the landscape. Respondents with higher educational levels and greater concern for the biological and traditional farming knowledge aspects of the rice terraces were also more inclined to favor sustainable farming practices. Tourists preferred to maintain the naturalness and rurality of the agricultural landscape, and indicated that construction of excessive tourist facilities would cause the landscape to deteriorate. It was suggested that the local community and surroundings, including rural settlements, hills, and forests, should also be conserved together with the scenic terrace. | CHEN Bixia QIU Zhenmian NAKAMURA Koji | 2016 | Journal of Mountain Science2016，13，10： | 4 |
| 5 | CRISPR-Cas9-based genome-wide screening identified novel targets for treating sorafenib-resistant hepatocellular carcinoma:a cross-talk between FGF21 and the NRF2 pathway显示文摘The treatment of hepatocellular carcinoma(HCC)has been dominated by multikinase inhibitors for more than a decade.However,drug resistance can severely restrict the efficacy of these drugs.Using CRISPR/CAS9 genome library screening,we evaluated Kelch-like ECH-associated protein 1(KEAP1)as a key regulator of sorafenib’s susceptibility in HCC.We also investigated whether KEAP1’s knockdown can stabilize nuclear factor(erythroid-derived 2)-like 2(NRF2)protein levels that led to sorafenib’s resistance,including an NRF2 inhibitor that can synergize with sorafenib to abolish HCC’s growth in vitro and in vivo.Furthermore,we clarified that fibroblast growth factor 21(FGF21)is an important downstream regulator of NRF2 in HCC.Intriguingly,we observed that FGF21 bound to NRF2 through the C-terminus of FGF21,thereby stabilizing NRF2 by reducing its ubiquitination and generating a positive feedback loop in sorafenib-resistant HCC.These findings,therefore,propose that targeting FGF21 is a promising strategy to combat HCC sorafenib’s resistance. | Jiang Chen Shi Jiang Huijiang Shao Bixia Li Tong Ji Daniel Staiculescu Jiayan He Jie Zhao Liuxin Cai Xiao Liang Junjie Xu Xiujun Cai | 2022 | Science China(Life Sciences)2022，65，10： | 4 |
| 6 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 7 | Heteroepitaxial Growth and Characterization of 3C-SiC Films on Si Substrates Using LPVCVD显示文摘3C-SiC films have been deposited on Si (111) substrates by the Iow-pressure vertical chemical vapor deposition (LPVCVD) with gas mixtures of SiH4, C3H8 and Ha. The growth mechanism of SiC films can be obtained through the observations using field emission scanning electron microscope (FESEM). It is found that the growth process varies from surface control to diffusion control when the deposition temperature increases from 1270 to 1350℃. The X-ray diffraction (XRD) patterns show that the SiC films have good crystallinity and strong preferred orientation.The results of the high resolution transmission electron microscopy (HRTEM) image and the transmission electron diffraction (TED) pattern indicate a peculiar superlattice structure of the film. The values of the binding energy in the high resolution X-ray photoelectron spectra (XPS) further confirm the formation of SiC. | Haiwu ZHENG Junjie ZHU Zhuxi FU Bixia LIN Xiaoguang LI | 2005 | Journal of Materials Science & Technology2005，21，4： | 4 |
| 8 | Chinese cohort study of chronic kidney disease: design and methods显示文摘 | Gao Bixia Zhang Luxia Wang Haiyan Zhao Minghui On behalf of the Chinese Cohort Study of Chronic KidneyDisease (C-STRIDE) | 2014 | Chinese Medical Journal2014，，11： | 4 |
| 9 | 贵州特大古银杏的分布与生长特性--贵州古银杏种质资源考察Ⅺ显示文摘在充分调查的基础上,发现当代银杏中存在一类性征特殊的特大古银杏类群。首先是形态、大小及树龄差别极大,其生长生物学特性和生长节律非常特殊,表现出类似地质年代古银杏的古老原始形态、结构和功能。着重研究该特大古银杏的性质、数量、分布特征及'多代同株'生长现象。首次指出'多代同株'个体为银杏地质年代早期普遍存在着的个体,现代的'多代同株'者为地质时期古银杏的一种'返祖现象'和'返祖个体';首次发现'联合基茎'周期性大爆发'类形成层根颈克隆乔木生长圈'生长现象,并且为'多代同株'者的生长动力学基础。查明'黔中山原'以安顺、长顺、贵阳、龙里、贵定、福泉、麻江一线为贵州野银杏的原始栖息地。并以特大古银杏的分布现状为依据,发现野银杏的古地理学分布与现代分布完全重叠一致,再次证明贵州银杏族群的野生性质。 | 向准 罗倩 涂成龙 向应海 Bixia Xiang | 2012 | 林业科技开发2012，26，3： | 3 |
| 10 | Enantioseparation of amino acid derivatives on an immobilized network polymer derived from L-tartaric acid显示文摘 | WENG Wen WANG Qinghua YAO Bixia | 2004 | J Chromatogr: A2004，1042，： | 1 |
| 11 | Market differential evaluation of strategic alliances in the pharmaceutical bioteeh industry显示文摘 | Xu Bixia | 2006 | Journal of High Technology Management Research2006，，17： | 1 |
| 12 | Chinese tomato yelIow Ieaf curl virus— a new species of geminivirus显示文摘 | Yule Liu Jianhe Cai Dongling Li Bixia Qin Bo Tian | 1998 | Science in China Series C: Life Sciences1998，，4： | 1 |
| 13 | Chinese and Western medicine treatment of 57 cases of dysfunctional uterine bleeding in adolescence显示文摘 | ho Yi Meng Petrel Wang Bixia | 2011 | Guide of China Medicine2011，，20： | 1 |
| 14 | Effects of baicalcin on rat myocardial ischemia and neonatal cardiomyocyte injury 显示文摘 | Peng Jun Xu Wenjie He Bixia | 2011 | Chin J Natural Med2011，9，2： | 1 |
| 15 | Planted Forest and Diverse Cultures in Ecological Village Planning: A Case Study in Tarama Island, Okinawa Prefecture, Japan显示文摘 | Bixia C Yuei N Takakazu U | 2013 | Small-scale Forestry2013，，： | 1 |
| 16 | Green Luminescent Center in Undoped Zinc Oxide Films Deposited on Silicon Substrates显示文摘 | Lin Bixia Fu Zhuxi Jia Yunbo | 2001 | Appl Phys Lett2001，79，： | 1 |
| 17 | Diagnosis of ABCB11 gene mutations in children with intrahepatic cholestasisusing high resolution melting analysis and direct sequencing显示文摘 | Guorui Hu Ping He Zhifeng Liu Qian Chen Bixia Zheng Qihua Zhang | 2014 | Molecular Medicine Reports2014，，3： | 1 |
| 18 | Exp2 polymorphisms associated with variation for fiber quality properties in cotton(Gossypium spp.)显示文摘Plant expansins are a group of extracellular proteins thought to affect the quality of cotton fibers. Previous expression profile analysis revealed that six Expansin A genes are present in cotton, of which two(GhExp1 and GhExp2) produce transcripts that are specific to the developing cotton fiber. To identify the phenotypic function of Exp2, and to determine whether nucleotide variation among alleles of Exp2 affects fiber quality, candidate gene association mapping was conducted. Gene-specific primers were designed to amplify the Exp2 gene. By amplicon sequencing, the nucleotide diversity of Exp2 was investigated across92 accessions(including 7 Gossypium arboreum, 74 Gossypium hirsutum, and 11 Gossypium barbadense accessions) with different fiber qualities. Twenty-six SNPs and seven InDels including 14 from the coding region of Exp2 were detected, forming twelve distinct haplotypes in the cotton collection. Among the 14 SNPs in the coding region, five were missense mutations and nine were synonymous nucleotide changes. The average SNP/InDel per nucleotide ratio was 2.61%(one SNP per 39 bp), with 1.81 and 3.87% occurring in coding and non-coding regions, respectively. Nucleotide and haplotype diversity across the entire Exp2 region was 0.00603(π) and 0.844, respectively, and diversity in non-coding regions was higher than that in coding regions. For linkage disequilibrium(LD), the mean r2 value for all polymorphism loci pairs was 0.48, and LD did not decay over 748 bp. Based on132 simple sequence repeat(SSR) loci evenly covering 26 chromosomes, the population structure was estimated, and the accessions were divided into seven groups that agreed well with their genomic origin and evolutionary history. A general linear model was used to calculate the Exp2-wide diversity–trait associations of 5 fiber quality traits, considering population structure(Q). Four SNPs in Exp2 were associated with at least one of the fiber quality traits, but not with fiber elongation. The highest positive effect on UHML and STR was observed for haplotype Hap_6 of Exp2. There was a significant association of Exp2 with fiber quality traits. There were many haplotypes in the Exp2 region, of which the most favorable was Hap_6. The association between nucleotide diversity and these fiber traitssheds light on the gene's potential contribution to the improvement of fiber quality, and should be useful to facilitate MAS programs in cotton. | Daohua He Zhongping Lei Hongyi Xing Baoshan Tang Junxing Zhao Bixia Lu | 2014 | The Crop Journal2014，2，5： | 1 |
| 19 | Photoluminescence and structure of ZnO films deposited on Si substrates by MOCVD显示文摘 | Fu Zhuxi Lin Bixia Zu Jie | 2002 | Thin Solid Films2002，402，12： | 1 |
| 20 | Chinese tomato yelIow Ieaf curl virus— a new species of geminivirus显示文摘 | Yule Liu Jianhe Cai Dongling Li Bixia Qin Bo Tian | 1998 | Science in China Series C: Life Sciences1998，，4： | 1 |
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