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| 1 | Over expression of resistin in adipose tissue of the obese induces insulin resistance显示文摘AIM: To compare resistin mRNA expression in subcutaneous adipose tissue (SAT) and its correlation with insulin resistance (IR) in postmenopausal obese women. METHODS: A total of 68 postmenopausal women (non obese = 34 and obese = 34) were enrolled for the study. The women of the two groups were age matched (49-70 years). Fasting blood samples were collected at admission and abdominal SAT was obtained during surgery for gall bladder stones or hysterectomy. Physical parameters [age, height, weight, body mass index (BMI)] were measured. Biochemical (plasma insulin and plasma glucose) parameters were estimated by enzymatic methods. RNA was isolated by the Trizol method.SAT resistin mRNA expression was done by real time- reverse transcription polymerase chain reaction (RT-PCR) by using Quanti Tect SYBR Green RT-PCR master mix. Data was analyzed using independent Student's t test, correlation and simple linear regression analysis. RESULTS: The mean weight (52.81 ± 8.04 kg vs 79.56 ± 9.91 kg; P < 0.001), BMI (20.23 ± 3.05 kg/m 2 vs 32.19 ± 4.86 kg/m 2 ; P < 0.001), insulin (8.47 ± 3.24 U/mL vs 14.67 ± 2.18 U/mL; P < 0.001), glucose (97.44 ± 11.31 mg/dL vs 109.67 ± 8.02 mg/dL; P < 0.001) and homeostasis model assessment index (2.01 ± 0.73 vs 3.96 ± 0.61; P < 0.001) were significantly higher in postmenopausal obese women compared to postmenopausal non obese women. The mean serum resistin level was also significantly higher in postmeno-pausal obese women compared to postmenopausal non obese women (9.05 ± 5.15 vs 13.92 ± 6.32, P < 0.001). Furthermore, the mean SAT resistin mRNA expression was also significantly (0.023 ± 0.008 vs 0.036 ± 0.009; P < 0.001) higher and over expressed 1.62 fold (upregulated) in postmenopausal obese women compared to postmenopausal non obese women. In postmeno-pausal obese women, the relative SAT resistin mRNA expression showed positive (direct) and significant correlation with BMI (r = 0.78, P < 0.001) and serum resistin (r = 0.76, P < 0.001). Furthermore, the SAT resistin mRNA expression in postmenopausal obese women also showed significant and direct association (r = 0.45, P < 0.01) with IR, while in postmenopausal non obese women it did not show any association (r = -0.04, P > 0.05). CONCLUSION: Increased SAT resistin mRNA expres-sion probably leads to inducing insulin resistance and thus may be associated with obesity-related disorders in postmenopausal obese women. | Sadashiv Sunita Tiwari S Dhananjai Bhola N Paul Sandeep Kumar Abhijit Chandra Mahendra PS Negi | 2012 | World Journal of Diabetes2012，3，7： | 10 |
| 2 | Three global conditions for biodiversity conservation and sustainable use: an implementation framework显示文摘‘Nature and its vital contributions to people,which together embody biodiversity and ecosystem functions and services,are deteriorating worldwide’[1].The United Nations Convention on Biological Diversity(CBD)is intended to ensure conservation of biodiversity,its wise use,and sharing of benefits from use of genetic resources.Through it,the Strategic Plan(SP)for Biodiversity 2011-2020 was created to make progress toward a vision of humanity‘Living in Harmony with N ature’by 2050[2].W hen that vision is realized,biodiversity will be valued,conserved,restored,and wisely used,so it can maintain ecosystem services and sustain a healthy planet. | Harvey Locke Erie C.Ellis Oscar Venter Richard Schuster Keping Ma Xiaoli Shen Stephen Woodley Naomi Kingston Nina Bhola Bernardo B.N.Strassburg Axel Paulsch Brooke Williams James E.M.Watson | 2019 | National Science Review2019，6，6： | 6 |
| 3 | Cut-off of body mass index and waist circumference to predict hypertension in Indian adults显示文摘AIM: To determine the cut-off values of body mass index(BMI) and waist circumference to predict hypertension in adults in north India.METHODS: A community based cross-sectional study was conducted in 801 subjects in Kanpur, aged 20 years and above, using multistage stratified random sampling technique. A pre-tested structured question-naire was used to elicit the required information from the study participants and the diagnostic criteria for hypertension were taken according to the Seventh Joint National Committee Report on Hypertension(JNC-7). Receiver operating characteristic(ROC) analysis was used to estimate the cut-off values of BMI and waist circumference to predict hypertension.RESULTS: The ROC analysis revealed that BMI is a good predictor of hypertension for both men(area under the ROC curve 0.714) and women(area under the ROC curve 0.821). The cut-off values of BMI for predicting hypertension were identified as ≥ 24.5 kg/m2 in men and ≥ 24.9 kg/m2 in women. Similarly, the ROC analysis for waist circumference showed that it is a good predictor of hypertension both for men(area under the ROC curve 0.784) and women(area under the ROC curve 0.815). The cut-offs for waist circumference for predicting hypertension were estimated as ≥ 83 cm for men and ≥ 78 cm for women. Adults with high BMI or high waist circumference had a higher prevalence of hypertension, respectively.CONCLUSION: Simple anthropometric measurements such as BMI and waist circumference can be used for screening people at increased risk of hypertension in order to refer them for more careful and early diagnostic evaluation. Policies and programs are required for primary and secondary prevention of hypertension. | Tanu Midha Vinay Krishna Bhola Nath Ranjeeta Kumari Yashwant Kumar Rao Umeshwar Pandey Samarjeet Kaur | 2014 | World Journal of Clinical Cases2014，2，7： | 2 |
| 4 | A novel optical microring resonatoraccelerometer显示文摘 | Bipin Bhola William H Steier | 2007 | IEEE Sensors Journal2007，12，7： | 1 |
| 5 | Influence of sulfate reducing bacterial biofilm on corrosion behavior of low-alloy, high-strength steel (API-5L X80)显示文摘 | Faisal M. AlAbbas Charles Williamson Shaily M. Bhola John R. Spear David L. Olson Brajendra Mishra Anthony E. Kakpovbia | 2012 | International Biodeterioration & Biodegradation2012，，： | 1 |
| 6 | Logistics chain modeling 显示文摘 | Slants P A Bhola B Evers J J M | 1995 | European journal of operational research1995，87，： | 1 |
| 7 | Penetration of projectiles in composite laminates显示文摘 | Patel B P Bhola S K Ganapathi M | 2004 | Defence Sci J2004，54，2： | 1 |
| 8 | Deposition of till droplets on a steel plate: simula- tions and experiments显示文摘 | PASANDIDEH-FARD M BHOLA R CHANDRA S | 1998 | International Journal of Heat and Mass Transfer1998，41，19： | 1 |
| 9 | Logistic chain modeling 显示文摘 | Slats P A Bhola B Evers J J M | 1995 | European Journal of Operational Research1995，87，： | 1 |
| 10 | Self-Assembling Peptide as a Potential Carrier for Hydrophobic Anticancer Drug Ellip- ticine : Complexation, Release and In Vitro Delivery 显示文摘 | Fung SY Yang H Bhola PT | 2009 | Adv Funct Mater2009，19，1： | 1 |
| 11 | Deposi- tion of tin droplets on a steel plate: Simulation and ex- periments 显示文摘 | Pasandideh-Fard M Bhola R Chandra S | 1998 | International Journal of Heat and Mass Transfer1998，41，： | 1 |
| 12 | Immediate implant placement: clinical decisions,advantages,and disadvantages显示文摘 | Bhola M Neely AL Kolhatkar S | 2008 | J Prosthodont2008，17，7： | 1 |
| 13 | Computer modeling study of the mechanism of optic nerve injury in blunt trauma显示文摘 | Cirovic S Bhola RM Hose DR | 2006 | Br J Oph- thalmol2006，90，6： | 1 |
| 14 | Immediate implant placement:clinical decisions,advantages and disadvantages显示文摘 | Bhola M Neely AL Kolhalkar S | | 0，，07： | 1 |
| 15 | TGF-13 inhibition enhances chemotherapy action against triple-negative breast cancer 显示文摘 | Bhola NE Balko JM Dugger TC | 2013 | J Clin Invest2013，123，3： | 1 |
| 16 | A Novel Optical Microring Resonator Accelerometer 显示文摘 | Bipin Bhola William H Steier | 2007 | IEEE Sensors Journal2007，12，7： | 1 |
| 17 | Deposition of tin droplets on a steel plate: simulations and experiments 显示文摘 | PASANDIDEH-FARD M BHOLA R CHANDRA S | 1998 | International Journal of Heat and Mass Transfer1998，41，19： | 1 |
| 18 | Pilot study of the influence of eyeliner cosmetics on the molecular structure of human meibum 显示文摘 | Hunter M Bhola R Yappert MC | 2015 | Ophthalmic Res2015，53，3： | 1 |
| 19 | Hemodialysis catheter care:current recommendations for nursing practice in North America显示文摘 | Dinwiddie LC Bhola C | 2010 | Nephrology Nursing Journal(Journal of The American Nephrology Nurses''Association)2010，37，52： | 1 |
| 20 | Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer显示文摘 | Zhang Q Bhola N Lui V | 2007 | Mol Cancer Ther2007，6，： | 1 |
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