|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Whole-genome,transcriptome,and methylome analyses provide insights into the evolution of platycoside biosynthesis in Platycodon grandiflorus,a medicinal plant显示文摘Triterpenoid saponins(TSs)are common plant defense phytochemicals with potential pharmaceutical properties.Platycodon grandiflorus(Campanulaceae)has been traditionally used to treat bronchitis and asthma in East Asia.The oleanane-type TSs,platycosides,are a major component of the P.grandiflorus root extract.Recent studies show that platycosides exhibit anti-inflammatory,antiobesity,anticancer,antiviral,and antiallergy properties.However,the evolutionary history of platycoside biosynthesis genes remains unknown.In this study,we sequenced the genome of P.grandiflorus and investigated the genes involved in platycoside biosynthesis.The draft genome of P.grandiflorus is 680.1 Mb long and contains 40,017 protein-coding genes.Genomic analysis revealed that the CYP716 family genes play a major role in platycoside oxidation.The CYP716 gene family of P.grandiflorus was much larger than that of other Asterid species.Orthologous gene annotation also revealed the expansion ofβ-amyrin synthases(bASs)in P.grandiflorus,which was confirmed by tissue-specific gene expression.In these expanded gene families,we identified key genes showing preferential expression in roots and association with platycoside biosynthesis.In addition,wholegenome bisulfite sequencing showed that CYP716 and bAS genes are hypomethylated in P.grandiflorus,suggesting that epigenetic modification of these two gene families affects platycoside biosynthesis.Thus whole-genome,transcriptome,and methylome data of P.grandiflorus provide novel insights into the regulation of platycoside biosynthesis by CYP716 and bAS gene families. | Jungeun Kim Sang-Ho Kang Sin-Gi Park Tae-Jin Yang Yi Lee Ok Tae Kim Oksung Chung Jungho Lee Jae-Pil Choi Soo-Jin Kwon Keunpyo Lee Byoung-Ohg Ahn Dong Jin Lee Seung-il Yoo In-Gang Shin Yurry Um Dae Young Lee Geum-Soog Kim Chang Pyo Hong Jong Bhak Chang-Kug Kim | 2020 | Horticulture Research2020，7，1： | 2 |
| 2 | Gene expression pattern in transmitochondrial cytoplasmic hybrid cells harboring type 2 diabetes-associated mitochondrial DNA haplogroups 显示文摘 | Hwang S Kwak SH Bhak J | 2011 | PLoS One2011，6，22： | 1 |
| 3 | Parameter selection of pocket extraction algorithm using interaction interface显示文摘Pockets in proteins have been known to be very important for the life process. There have been several studies in the past to automatically extract the pockets from the structure information of known proteins. However, it is difficult to find a study comparing the precision of the extracted pockets from known pockets on the protein. In this paper, we propose an algorithm for extracting pockets from structure data of proteins and analyze the quality of the algorithm by comparing the extracted pockets with some known pockets. These results in this paper can be used to set the parameter values of the pocket extraction algorithm for getting better results. | KIM Chong-Min WON Chung-In RYU Joonghyun CHO Cheol-Hyung BHAK Jonghwa KIM Deok-Soo | 2006 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2006，7，9： | 1 |
| 4 | Different activation treatments for successful development of bovine oocytes following intaracytoplasmic sperm injection显示文摘 | Ock SA Bhak JS Balasubrarnanian S | 2003 | Zygote2003，11，： | 1 |
| 5 | Developmental rate and ploidy of embryos produced by nuclear transfer with different activation treatments in cattle显示文摘 | Bhak JS Lee SL Ock SA Mohana Kumar B | 2006 | Anim Reprod Sci2006，92，12： | 1 |
| 6 | Response surface analysis of solid state growth of Pleurotus ostreatus mycelia utilizing whey permeate显示文摘 | Bhak G Song M Lee S | 2005 | Biotechnology Letters2005，27，： | 1 |
| 7 | The genetic basis of white tigers显示文摘 | Xu X Dong GX Hu XS Miao L Zhang XL Zhang DL Yang HD Zhang TY Zou ZT Zhang TT Zhuang Y Bhak J Cho YS Dai WT Jiang TJ Xie C Li RQ Luo SJ | | 0，，11： | 1 |
| 8 | Reponse surface analysis of solid state growth of Pleurotus ostreatus mycelia utilizing whey permeate 显示文摘 | Ghibom Bhak Minkyung Song Seungyong Lee | 2005 | Biotechnology Letters2005，27，： | 1 |
| 9 | Response surface analysis of solid state growth of Pleurotus ostreatus mycelia utilizing whey permeate 显示文摘 | Bhak G Song M Lee S | 2005 | Biotechnology letters2005，27，20： | 1 |
| 10 | Epidermal growth factor receptor (EGFR) in implications显示文摘 | Kutton NAA Govard Ivan Bhak NM | 1997 | Indian J Dent Res1997，8，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员