|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | A theory for the ablation of glassy materials显示文摘 | BETHE H A ADAMS M C | 1959 | Journal of the Aero/Space Sciences1959，26，6： | 1 |
| 3 | TMS1,a novel pro-apoptotic caspase recruitment domain protein,is a target ofmethylation-induced gene silencing in human breast cancers显示文摘 | Kerry E C Beth/M Claire E B | 2000 | Cancer Res2000，60，22： | 1 |
| 4 | The prognostic significance of thrombocytosis in epithelial ovarian carcinoma显示文摘 | Andrew J Li Alison C Madden Ilana Cass Ronald S Leuchter Leo D Lagasse Beth Y Karlan | 2003 | Gynecologic Oncology2003，，1： | 1 |
| 5 | Improved specificity for detection of Mycobacterium bo visin fresh tissues using IS6110 real-time PCR显示文摘 | Thacker Tyler C Harris Beth Palmer Mitchell V | 2011 | BMC VetRes2011，7，： | 1 |
| 6 | Reference librarians at the reference desk in a learning commons : a mixed methods evaluation 显示文摘 | Elizabeth B Fitzpatrick Anne C Moore Beth W Lang | | The0，200，3： | 1 |
| 7 | A comparison of parathyroid hormone‐related protein (1‐36) and parathyroid hormone (1‐34) on markers of bone turnover and bone density in postmenopausal women: The PrOP study显示文摘 | Mara J Horwitz Marilyn Augustine Leila Kahn Emily Martin Christine C Oakley Raquel M Carneiro Mary Beth Tedesco Angela Laslavic Susan M Sereika Alessandro Bisello Adolfo Garcia‐Oca?a Caren M Gundberg Jane A Cauley Andrew F Stewart | 2013 | J Bone Miner Res2013，，11： | 1 |
| 8 | Homogeneous bent functions, invariants, and designs显示文摘 | Charnes C Rottler M Beth T | 2002 | Design Codes and Cryptography2002，26，： | 1 |
| 9 | Evaluation of a unique, nurse - inserted, peripherally inserted central catheter program显示文摘 | Beth G Cristina M Bairbre C | 2005 | Pediatrics2005，115，： | 1 |
| 10 | Metrics for ranking the performance of supercomputers显示文摘 | Tzu Y C Meghan G Beth S | 2006 | CTWatch2006，2，4： | 1 |
| 11 | Virulence genotypeof Pasteurella multocida strains isolated from different hostswith various disease status显示文摘 | Ewers C Lubke-becker A Bethe A | 2006 | Vet Microbiol2006，114，34： | 1 |
| 12 | Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8^+T Lymphocytes 显示文摘 | Steven R F Beth D J Allison C C | 2008 | The Journal of Immunology2008，181，： | 1 |
| 13 | A model for the behaviour of magnetorheological materials 显示文摘 | JOLLY M R CARLSON J D MU'NOZ BETH C | 1996 | Smart Mater Struct1996，5，： | 1 |
| 14 | Virulence genotype of Pasteurella multocida strains isolated from different hosts with various disease status显示文摘 | EWERS C LBKE-BECKER A BETHE A | 2006 | Vet Microbiol2006，114，3： | 1 |
| 15 | Stable carbon isotope ratios of fatty acids in seagrass and redhead ducks 显示文摘 | Beth Trust Hammer Marilyn L Fogel Thomas C Hoering | 1998 | Chemical Geology1998，152，： | 1 |
| 16 | Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes显示文摘 | Steven R F Beth D J Allison C C | 2008 | The Journal of Immunology2008，181，： | 1 |
| 17 | Effects of a brief,theory - based STD - Prevention Program for female eollege students 显示文摘 | Beth J Michael C | 2001 | J Adolesc Health2001，29，6： | 1 |
| 18 | Virulence genotype of Pasteurella multocida strains isolated from different hosts with various disease status显示文摘 | Ewers C Lubke-Becker A Bethe A | 2006 | Vet Microbiol2006，114，34： | 1 |
| 19 | The dominant logic: Retrospeetive and extension 显示文摘 | BETHS R A PRAHALAD C K | 1995 | Strategic Management Journal1995，16，1： | 1 |
| 20 | Quantm Reed-Solomon Co- des显示文摘 | Grassl M C eiselmonn W Beth T | 1999 | Applicable Algebra in Engineering Communication and Computation1999，13，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员