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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Inflammatory and anti-inflammatory effects of soybean agglutinin 显示文摘 | Benjamin C F Fiqueriedo R C Henriques M G et ol | 1997 | Braz J Med Biol Res1997，30，： | 1 |
| 3 | Gold-coated iron nanoparticles:a novel magnetic resonance agent for T1 and T2 weighted imaging显示文摘 | SUNG J C BENJAMIN R J ANGELIQUE Y L | 2006 | Nanotechnology2006，17，3： | 1 |
| 4 | NOM removal by slow sand filtration through iron oxide-coated olivine 显示文摘 | McMeen C R Benjamin M M | 1997 | J AWWA1997，89，2： | 1 |
| 5 | Basic fibroblast growth factor-induced cell death is effected through sustained activation of p38MAPK and up-regulation of the death receptor p75NTR显示文摘 | Andrew J K W Benjamin C D James R B | 2004 | J Biol Chem2004，279，47： | 1 |
| 6 | The realm of mi- crobial lipases in biotechnology显示文摘 | Pandey A Benjamin S Soeeol C R | 1999 | Biotechnol Appl Bio- chem1999，，29： | 1 |
| 7 | The realm of microbial lipases in biotechnology 显示文摘 | PANDEY A BENJAMIN S SOOCOL C R | 1999 | Biotechnol Appl Biochem1999，29，： | 1 |
| 8 | The realm of microbial lipases in biotechnology 显示文摘 | PANDEY A BENJAMIN S SOCCOL C R | 1999 | Biotechnology and Applied Biochemistry1999，29，： | 1 |
| 9 | What is the proper threshold for platelet transfusion in patients with chemotherapy- induced thrombocytopenia 显示文摘 | Benjamin R J Anderson K C | 2002 | Critical Rev Oncol Hematol2002，42，： | 1 |
| 10 | Inflammatory and anti-inflammatory effects of soybean agglutinin显示文摘 | BENJAMIN C F FIQUERIEDO R C HENRIQUES M G | 1997 | Braz J Med Biol Res1997，30，： | 1 |
| 11 | Quantitative studies of inhibitors of ADP ribosylation in vitro and in vivo 显示文摘 | Rankin P W Jacobson E L Benjamin R C | 1989 | J Biol Chem1989，264，8： | 1 |
| 12 | Experimental techniques in the field of pipeline integrity显示文摘 | Freire J L F Vieira R D Benjamin A C | 2003 | Experimental Techniques2003，，5： | 1 |
| 13 | Burst tests of pipeline with extensive longitudinal metal loss显示文摘 | Freire J L F Vieira R D Benjamin A C | 2006 | ExperimentalTechniques2006，，11： | 1 |
| 14 | The realm of microbial lipase in biotechnology显示文摘 | Pandey A Benjamin S School C R | | 0，，02： | 1 |
| 15 | High-grade pancreatic intraepithelial lesions: prevalence and implications in pancreatic neoplasia显示文摘BACKGROUND: High-grade pancreatic intraepithelial neoplasia(Pan IN-3), a precursor of pancreatic ductal adenocarcinoma(PDAC), is not universally detected in resected pancreatic neoplasms. We sought to determine the prevalence and prognostic relevance of Pan IN-3 lesions in primary surgical resections of PDACs and intraductal papillary mucinous neoplasms(IPMNs).METHODS: A retrospective review of a tertiary care center pathology database(1/2000-6/2014) was performed. Demographics, imaging, pathology, disease-recurrence, and survival data were reviewed.RESULTS: A total of 458 patients who underwent primary pancreatic resection were included. 'Pan IN-3' lesions were found in 74(16.2%) patients who either had PDAC(n=67) or main duct(MD)-IPMN(n=7). Among IPMN-MDs, Pan IN-3 lesions were exclusively found in those with pathological evidence of chronic pancreatitis. For PDACs, the median overall survival(OS) for pancreata with Pan IN-3 lesions was significantly better than those without(OS 1.12 years, interquartile range [IQR] 0.72, 2.05 years vs OS 0.86 years, IQR 0.64,1.60 years respectively; P=0.04). Multivariate Cox regression analysis demonstrated that the presence of Pan IN-3 lesions was associated with a reduced risk of death(HR=0.43; 95% CI: 0.23-0.82; P=0.01).CONCLUSIONS: Following primary resection of pancreatic adenocarcinoma, the lower survival observed in patients without Pan IN-3 lesions might suggest a state of complete or accelerated transformation. Further investigations are necessary to validate these findings that might impact disease prognosis and management. | Jean R Park Feng Li Veeral M Oza Brett C Sklaw Kevin M Cronley Michael Wellner Benjamin Swanson Somashekar G Krishna | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，2： | 1 |
| 16 | Efficacy of EMDR in children a meta-analysis显示文摘 | Rodenburg R Benjamin A de Roos C | 2009 | Clin Psychol Rev2009，29，7： | 1 |
| 17 | Topologicalproperties of stock market networks : The case of Brazil显示文摘 | Benjamin M T Thiago R S Daniel 0 C | 2010 | Physica A2010，389，： | 1 |
| 18 | The interrelationship between markets for new and ud durable goods显示文摘 | BENJAMIN D K KORMENDI R C | 1974 | Journal of Law and Eco- nomics1974，17，： | 1 |
| 19 | Part 6: Analysis of Pipeline Containing Interacting Corrosion Defects显示文摘 | BENJAMIN A C FREIRE J L F VIEIRA R D | 2007 | Experimental Techniques2007，31，3： | 1 |
| 20 | Burst tests of pipeline with extensive longitudinal metal loss显示文摘 | Freire J L F Vieira R D Benjamin A C | 2006 | Experimental Techniques2006，，11： | 1 |
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