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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization显示文摘AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.METHODS We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control(LLC), distant liver control(DLC), time to distant metastases(DM), progression free survival(PFS) and overall survival(OS).RESULTS The majority of patients were males(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a median age of 68 years(46-84 years). FDG-avid disease was found in 19(56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC(P = 0.02). Median follow up of patients following radioembolization was 12 months(1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS(P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS(all P < 0.05).CONCLUSION In this retrospective study, pre-treatment HCC FDGavidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization. | Yazan Abuodeh Arash O Naghavi Kamran A Ahmed Puja S Venkat Youngchul Kim Bela Kis Junsung Choi Benjamin Biebel Jennifer Sweeney Daniel A Anaya Richard Kim Mokenge Malafa Jessica M Frakes Sarah E Hoffe Ghassan El-Haddad | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 3 | Sudden sensorineural hearing loss显示文摘 | Benjamin E Schreiber Charlotte Agrup Dorian O Haskard Linda M Luxon | 2010 | The Lancet2010，，9721： | 1 |
| 4 | Diagnosis and localization of insulinoma: the value of modern magnetic resonance imaging in conjunction with calcium stimuluation catheterisation显示文摘 | Maralun R Druce Vasantha M Muthuppalaniappan Benjamin O' Leary | 2010 | European Journal of Endocrinology2010，162，： | 1 |
| 5 | Metformin therapy in a transgenic mouse model of Huntington's disease 显示文摘 | THONG C M JESSICA L B BENJAMIN O | 2007 | Neurosci Lett2007，411，2： | 1 |
| 6 | Relation of frequency and severity of mitral regurgitation to survival among patients with left ventricular systolic dysfunction and heart failure显示文摘 | Benjamin H Trichon G.Michael Felker Linda K Shaw Christopher H Cabell Christopher M O’Connor | 2003 | The American Journal of Cardiology2003，，5： | 1 |
| 7 | Phenoloxidase from shrimp(Penaeus setiferus) : purification and some properties显示文摘 | Benjamin K S Maurice R M Steven O W | 1987 | Journal of Agricultural and Food Chemistry1987，，35： | 1 |
| 8 | A re- view of state regulations to promote physical activity and safety on playgrounds in child care centers and family child care homes 显示文摘 | Cradock A L O'Donnell E M Benjamin S E | 2010 | J Phys Act Health2010，7，： | 1 |
| 9 | Utilization of Interventional Radiology in the Postoperative Management of Patients after Surgery for Locally Advanced and Recurrent Rectal Cancer显示文摘 | Llaguna Omar H Calvo Benjamin F Stitzenberg Karyn B Deal Allison M Burke Charles T Dixon Robert G Stavas Joseph M Meyers Michael O | 2011 | The American Surgeon2011，，8： | 1 |
| 10 | Multiple - site adsorption of Cd, Cu, Zn and Pb on amorphous iron oxyhydroxide显示文摘 | Benjamin M M Leckie J O | 1981 | Journal of Colloid Interface Science1981，79，： | 1 |
| 11 | EHD2 shuttles to the nucleus and represses transciption显示文摘 | Pekar O Benjamin S Horowitz M | 2012 | Biochem J2012，444，3： | 1 |
| 12 | Testing for time-varying long-range dependence in volatility for emerging markets显示文摘 | Daniel O Cajueiro Benjamin M Tabak | 2005 | Physica A2005，346，： | 1 |
| 13 | Multiple site adsorption of Cd, Cu, Zn and Pb onamorphous iron oxyhydroxide 显示文摘 | Benjamin M M Leckie J O | 1981 | J Coll Interf Sci1981，79，1： | 1 |
| 14 | Are the crude oil markets becoming weakly efficient over time? A test for time-varying long-range dependence in prices and volatility显示文摘 | Tabak Benjamin M Cajueiro Daniel O | 2007 | Energy Economics2007，29，1： | 1 |
| 15 | Polyphenol oxidase of royal ann cherries:purification and characterization显示文摘 | Benjamin N O Montgomery M W | 1973 | J Food Sci1973，38，： | 1 |
| 16 | Effects of complexation by Cl^-,SO4^2-,and S2O3^2-adsorption behavior of Cd on oxide surfaces显示文摘 | Benjamin M M Leckie J O | 1982 | Environ Sci Tech1982，16，： | 1 |
| 17 | Evidence of long range dependence in Asian equity markets: The role of liquidity and market restric- tions显示文摘 | Daniel O C Benjamin M T | 2007 | Physica A2007，342，： | 1 |
| 18 | Incorporation of sparingly soluble species in mesostructured surfactant - polymer films 显示文摘 | BENJAMIN MD O'DRISCOLL ADRIAN M HAWLEY KAREN J EDLER | 2008 | Journal of Colloid and Interface Science2008，317，2： | 1 |
| 19 | Multiple site adsorption of Cd Cu Zn and Pb on amorphous iron oxyhydroxide显示文摘 | Benjamin M M Leckie J O | 1981 | Colloid Interface Sci- ence1981，79，5： | 1 |
| 20 | Inflammatory and anti-inflammatory effect of soybean agglutinin显示文摘 | BENJAMIN C F FIGUEIREDO R C HENRIQUES M G M O | 1997 | Bra- zilian Journal of Medical and Biological Research1997，30，： | 1 |
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