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| 1 | A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients显示文摘AIM:To investigate whether probiotic bacteria,given perioperatively,might adhere to the colonic mucosa, reduce concentration of pathogens in stools,and modulate the local immune function. METHODS:A randomized,double-blind clinical trial was carried out in 31 subjects undergoing elective colorectal resection for cancer.Patients were allocated to receive either a placebo(group A,n=10),or a dose of 10 7 of a mixture of Bifidobacterium longum(BB536) and Lactobacillus johnsonii(La1)(group B,n=11),or the same mixture at a concentration of 10 9 (group C,n=10).Probiotics,or a placebo,were given orally 2 doses/d for 3 d before operation.The same treatment continued postoperatively from day two to day four. Stools were collected before treatment,during surgery (day 0)and 5 d after operation.During the operation, colonic mucosa samples were harvested to evaluate bacterial adherence and to assess the phenotype of dendritic cells(DCs)and lymphocyte subsets by surface antigen expression(flow cytometry).The presence of BB536 and La1 was evaluated by the random amplified polymorphism DNA method with specific polymerase chain reaction probes. RESULTS:The three groups were balanced for baseline and surgical parameters.BB536 was never found at any time-points studied.At day 0,La1 was present in 6/10(60%)patients in either stools or by biopsy in group C,in 3/11(27.2%)in group B,and none in the placebo group(P=0.02,C vs A).There was a linear correlation between dose given and number of adher- ent La1(P=0.01).The rate of mucosal colonization by enterobacteriacae was 30%(3/10)in C,81.8%(9/11) in B and 70%(7/10)in A(P=0.03,C vs B).The Enterobacteriacae count in stools was 2.4(log10 scale) in C,4.6 in B,and 4.5 in A(P=0.07,C vs A and B). The same trend was observed for colonizing enterococ- ci.La1 was not found at day+5.We observed greater expression of CD3,CD4,CD8,and naive and memory lymphocyte subsets in group C than in group A with a dose response trend(C>B>A).Treatment didnot affect DC phenotype or activation,but after ex vivo stimulation with lipopolysaccharides,groups C and B had a lower proliferation rate compared to group A (P=0.04).Moreover,dendritic phenotypes CD83-123, CD83-HLADR,and CD83-11c(markers of activation) were significantly less expressed in patients colonized with La1(P=0.03 vs not colonized). CONCLUSION:La1,but not BB536,adheres to the colonic mucosa,and affects intestinal microbiota byreducing the concentration of pathogens and modulates local immunity. | Luca Gianotti Lorenzo Morelli Francesca Galbiati Simona Rocchetti Sara Coppola Aldo Beneduce Cristina Gilardini Daniela Zonenschain Angelo Nespoli Marco Braga | 2010 | World Journal of Gastroenterology2010，16，2： | 18 |
| 2 | Pancreatic Metastasis From Renal Cell Carcinoma: Which Patients Benefit From Surgical Resection?显示文摘 | Alessandro Zerbi MD Enrico Ortolano MD Gianpaolo Balzano MD Anna Borri MD Aldo Alberto Beneduce MD Valerio Di Carlo MD | 2008 | Annals of Surgical Oncology2008，，4： | 2 |
| 3 | Biogenic amine in wines显示文摘 | Beneduce L Romano A Capozzi V | 2010 | Annals of Microbiology2010，60，4： | 1 |
| 4 | Biogenic amine in wines显示文摘 | BENEDUCE L ROMANO A CAPOZZ1 V | 2010 | AnnMicrobiol2010，60，4： | 1 |
| 5 | Uncoupling protein-3 is a molecular determinant for the regulation of resting metabolic rate by thyroid hormone显示文摘 | De LANGE P LANNI A BENEDUCE L | 2001 | Endocrinology2001，142，8： | 1 |
| 6 | A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer显示文摘 | Luca Gianotti Marco Braga Luca Nespoli Giovanni Radaelli Aldo Beneduce Valerio Di Carlo | 2002 | Gastroenterology2002，，7： | 1 |
| 7 | Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: results from phase lIII studies 显示文摘 | Izzo F Marra P Beneduce G | 2004 | J Clin Oncol2004，22，10： | 1 |
| 8 | Biogenic amine in wines显示文摘 | BENEDUCE L ROMANO A CAPOZZI V | 2010 | Ann Microbiol2010，60，60： | 1 |
| 9 | Biogenic amine in wines显示文摘 | Beneduce L Romano A Capozzi V | | 0，，04： | 1 |
| 10 | Biogenic amine in wines显示文摘 | Beneduce L Romano A Capozzi V | 2010 | Annals of Microbiology2010，60，4： | 1 |
| 11 | Biogenic amine in wines显示文摘 | Beneduce L Romano A Capozzi V | 2010 | Annals of microbiology2010，60，4： | 1 |
| 12 | Improved transport critical current and irreversibility fields in mono-and multifilamentary Fe/MgB2 tapes and wires using fine powders显示文摘 | Flükiger R Lezza P Beneduce C | 2003 | Superconductor Science and Technology2003，16，： | 1 |
| 13 | Oral preoperative antioxidants in pancreatic surgery: A double-blind, randomized, clinical trial显示文摘 | Marco Braga Massimiliano Bissolati Simona Rocchetti Aldo Beneduce Nicolò Pecorelli Valerio Di Carlo | 2012 | Nutrition2012，，2： | 1 |
| 14 | A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer显示文摘 | Luca Gianotti Marco Braga Luca Nespoli Giovanni Radaelli Aldo Beneduce Valerio Di Carlo | 2002 | Gastroenterology2002，，7： | 1 |
| 15 | 显示文摘 | Beneduce C Giannini E Passerini R | 2002 | Physica C2002，，2： | 1 |
| 16 | Mutations in the 3A genomie region of two eytopathic strains of hepatitis A virus isolated in Italy显示文摘 | Morace G Pisani F Beneduce M | 1993 | Virus Res1993，28，： | 1 |
| 17 | Biogenic amine in wines显示文摘 | Beneduce L Romano A Capozzi V | 2010 | Ann Microbiol2010，60，4： | 1 |
| 18 | Molecular characterization of lactic acid populations associated with wine spoilage显示文摘 | Beneduce L Spano G Vernile A | 2004 | J Basic Microbiol2004，44，1： | 1 |
| 19 | Biogenic amine in wines显示文摘 | Beneduce L Romano A Capozzi V | 2010 | Annals of Microbiology2010，60，4： | 1 |
| 20 | Detection of circulating CEA-IgM complexes in early stage colorectal cancer显示文摘 | Castaldi F Marino M Beneduce L | 2005 | Int J Biol Markers2005，20，4： | 1 |
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