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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Algebraic reconstruction technique(ART) for threesimensional electron microscopy and X-ray photography显示文摘 | Gorden R Bender R Hermam G T | 1970 | J Theor Biol1970，29，： | 1 |
| 3 | A comparative study of dexmedetomidine with midazolam and midazolam alone for sedation during elective awake fiberoptic intubation显示文摘 | BERGESE S D BENDER S P MCSWEENEY T D | 2010 | J Clin Anesth2010，22，1： | 1 |
| 4 | Superheavy Nuclei in Self-consistent Nuclear Calculations 显示文摘 | Rutz K Bender M Buervenich T | 1997 | Phys Rev1997，56，1： | 1 |
| 5 | Algeraic reconstruction techniques(ART) for three-dimensional electron microscopy and x-ray photography显示文摘 | Gordon R Bender R Herman G T | 1970 | Journal of Theoretical Biology1970，29，： | 1 |
| 6 | Extended Aromatic Furan Amidino Derivatives as Anti-Pneumocystis carinii Agents显示文摘 | HOPKINS K T WILSON W D BENDER B C | | 0，，： | 1 |
| 7 | Eleetrospun ceramic fibers: composition, structure and the fate of precursors 显示文摘 | Turtle R W Chowdury A Bender E T | 2008 | Appl Surf Sci2008，254，16： | 1 |
| 8 | The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines 显示文摘 | Gonzalgo ML Hayashida T Bender CM | 1998 | Cancer Res1998，58，6： | 1 |
| 9 | The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines显示文摘 | Gonzalgo M L Hayashida T Bender C M | 1998 | Cancer Res1998，58，6： | 1 |
| 10 | A comparativestudy of dexmedetomidine with midazolam and midazolam alone forsedation during elective awake fiberoptic intubation显示文摘 | Berges S D Patrick Bender S McSweeney T D | 2010 | J Clin Anesth2010，22，1： | 1 |
| 11 | The primary response of human γ/δ ^+ T cells to Mycobacterium tuberculosis is restricted to Vγ9-bearing cells显示文摘 | Kabelitz DA Bender T Prospero S | 1991 | J Exp Mcd1991，173，6： | 1 |
| 12 | Fibrolamellar car- cinoma of the liver: radiologice-pathologic correlation 显示文摘 | Mcl_arney J K Rucker P T Bender G N | 1999 | Radio- graphics1999，19，2： | 1 |
| 13 | Upgrade of the Volvo Cars Aerodynamic Wind Tunnel显示文摘 | STERNéUS J WALKER T BENDER T | 2007 | SAE Paper2007，，： | 1 |
| 14 | Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents显示文摘 | Hopkins K T Wilson W D Bender B C | 1998 | Journal of Medicinal Chemistry1998，41，20： | 1 |
| 15 | Algebraic reconstruction techniques(ART)for three-dimensional electron microscopy and x-ray photography显示文摘 | Gordon R Bender R Herman G T | 1970 | J Theor Biol1970，29，： | 1 |
| 16 | Habitat loss and population decline: A meta-analysis of the patch size effect显示文摘 | Bender D J Contreras T A Fahring L | 1998 | Ecology1998，79，2： | 1 |
| 17 | Algebraic recon- struction techniques (ART) for three - dimensional e- lectron microscopy and X - ray photography 显示文摘 | Gordon R Bender R Herman G T | 1970 | Journal of theoretical Biology1970，29，3： | 1 |
| 18 | Identification of surface protective antigen (spa)types in Erysipelothrix reference strains and diagnostic samples by spa multi plexreal time andconventJonal PCR assays显示文摘 | SHEN H G BENDER J SOPRIESSNIG T | 2010 | lAppl mierobiol2010，109，4： | 1 |
| 19 | The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines显示文摘 | Gonzalgo M L Hayashida T Bender C M et a1 | 1998 | Cancer Res1998，58，6： | 1 |
| 20 | Evaluation of a German version of the tonsil and adenoid health status in- strument显示文摘 | Steinbichler T Bender B Blassnigg E | 2014 | J Otolaryngol Head Neck Surg2014，43，1： | 1 |
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