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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | CDMA/HDR: A bandwidth-efficient high-speed wireless data service for nomadic users 显示文摘 | P Bender P Black M Grob R Padovani N Sindhushayana A Viterbi | 2000 | IEEE Communication Magazine (S0733-8716)2000，38，7： | 1 |
| 3 | Real-case simulations of hurricane-ocean interaction using a high-resolution coupled model: effects on hurricane intensity显示文摘 | BENDER M A GINIS I | 2000 | Monthly Weather Review2000，128，4： | 1 |
| 4 | 显示文摘 | Jolly M R Bender J W | 1999 | J Intell Mater Syst Struct1999，513，： | 1 |
| 5 | A distributed routing algorithm for datagram traffic in LEO satellite networks显示文摘 | EKICI E AKYILDIZ I F BENDER M D | 2001 | IEEE/ACM Trans on Networking2001，9，12： | 1 |
| 6 | Moll energy for rural India显示文摘 | Frauke U René M J Benders | 2009 | Applied Energy2009，86，1： | 1 |
| 7 | Preconditions to ground based GPS water vapour tomography显示文摘 | Bender M and Raabe A | 2007 | Annales Geophysicae2007，25，8： | 1 |
| 8 | Quantum mechanical Carnot engine显示文摘 | Bender C M Brody D C Meister B K | 2000 | J Phys A2000，33，： | 1 |
| 9 | CDMA/HDR: A bandwidth-efficient high-speed wireless data service for nomadic users显示文摘 | BENDER P BLACK P GROB M | 2000 | IEEE Communications Magazine2000，38，7： | 1 |
| 10 | Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood 显示文摘 | Bender A Sapp M Schuler G | 1996 | Immunol Methods1996，196，2： | 1 |
| 11 | Transcriptional activation by tetracyclines in mammalian cells 显示文摘 | Gossen M Freundlieb S Bender G | 1995 | Science1995，268，5218： | 1 |
| 12 | Continuous High-Frequency Dissolved O-2/Ar Measurements by Equilibrator Inlet Mass Spectrometry 显示文摘 | Cassar N Barnett B A Bender M L | 2009 | Analytical Chemistry2009，81，5： | 1 |
| 13 | A numerical study of t he effect of a mountain range on a landfalling tropical cyclone显示文摘 | BENDER M A TULETA R E KURIHARA Y | 1985 | Mon Wea Rev1985，113，4： | 1 |
| 14 | Complex extension of quantum mechanics显示文摘 | BENDER C M BRODY D C JONES H F | | 0，，： | 1 |
| 15 | GNSS Water Vapour Tomography-expected Improvements by Combining GPS,GLONASS and Galileo Observations显示文摘 | BENDER M STOSIUS R ZUS F | 2011 | Advances in Space Research2011，47，5： | 1 |
| 16 | Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule 显示文摘 | Bender E Buist A Jurzak M | 2002 | Proc Natl Acad Sci USA2002，99，： | 1 |
| 17 | MLSR: a novel routing algorithm for multilayered satellite IP networks显示文摘 | AKYILDIZ L F EKICI E BENDER M D | 2002 | IEEE/ACM Trans on Networking2002，10，3： | 1 |
| 18 | Superheavy Nuclei in Self-consistent Nuclear Calculations 显示文摘 | Rutz K Bender M Buervenich T | 1997 | Phys Rev1997，56，1： | 1 |
| 19 | A routing algorithm for LEO satellite networks with dynamic connectivity显示文摘 | Uzunalioglu H Akyildiz I F Bender M D | 2000 | ACM-Baltzer J Wireless Networks (WINET)2000，6，3： | 1 |
| 20 | Transcriptional activation by tetracyclines in mammalian cells显示文摘 | Gossen M Freundlieb S Bender G | 1995 | Science1995，268，5218： | 1 |
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