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| 1 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 2 | Combination of ballistic lithotripsy and transurethral prostatetomy in bladder stones with benign prostatic hyperplasia: report of 120 cases 显示文摘 | Chtourou M Ben YA Binous MY | 2001 | J Endourol2001，15，： | 1 |
| 3 | Sclerotherapy of idi- opatic hydrocele with polidocanol:a study about 190 cases 显示文摘 | Sallami S Binous MY Ben Rhouma S | 2011 | Tu- nis Med2011，89，5： | 1 |
| 4 | Short - term acupuncture therapy is of no benefit in patients with moderate persistent asthma 显示文摘 | Shapira MY Berkman N Ben - David G Avital A Bardach E Breuer R | 2002 | Chest2002，121，5： | 1 |
| 5 | A hybrid original approach for prediction of the aerodynamic coefficients of an ATR-42 scaled wing model显示文摘A new approach for the prediction of lift, drag, and moment coefficients is presented.This approach is based on the support vector machines(SVMs) methodology and an optimization meta-heuristic algorithm called extended great deluge(EGD). The novelty of this approach is the hybridization between the SVM and the EGD algorithm. The EGD is used to optimize the SVM parameters. The training and validation of this new identification approach is realized using the aerodynamic coefficients of an ATR-42 wing model. The aerodynamic coefficients data are obtained with the XFoil software and experimental tests using the Price–Pa?¨doussis wind tunnel.The predicted results with our approach are compared with those from the XFoil software and experimental results for different flight cases of angles of attack and Mach numbers. The main purpose of this methodology is to rapidly predict aircraft aerodynamic coefficients. | Abdallah Ben Mosbah Ruxandra Mihaela Botez Thien My Dao | 2016 | Chinese Journal of Aeronautics2016，29，1： | 1 |
| 6 | Stab wounds of the renal artery branches: angiographic diagnosis and treatment by embolization显示文摘 | Fisher RG Ben MY Whingham C | 1989 | AJR1989，152，： | 1 |
| 7 | Stab wounds of the renal artery branches: angiographic diagnosis and treatment by embolization 显示文摘 | Fisher RG Ben MY Whingham C | 1989 | AJR1989，152，6： | 1 |
| 8 | Combination of ballistic lithotripsy and transurethral prostatectomy in bladder stones with benign prostatic hyperplasia:report of 120 cases显示文摘 | Chtourou M Ben Younes A Binous MY | 2001 | J Endourol2001，15，8： | 1 |
| 9 | Combina- tion of ballistic lithotripsy and transurethral prostatecto- my bladder stones with benign prostatic hyperplasia: re- port of 120 cases显示文摘 | Chtourou M Ben Younes A Binous MY | 2001 | J Endourol2001，15，8： | 1 |
| 10 | Combination of ballistic lithotripsy and transurethral prostatectomy bladder stones with benign prostatic hyperplasia: report of 120 cases 显示文摘 | CHTOUROU M BEN YA BINOUS MY | 2001 | J Endouro2001，15，8： | 1 |
| 11 | Combination of ballistic lithotripsy and transurethralprostatectomy in bladder stones with benign prostatichyperplasia:report of 120 cases 显示文摘 | CHTOUROU M BEN YOUNES A BINOUS MY | 2001 | J Endourol2001，15，8： | 1 |
| 12 | Combination of ballistic lithotripsy andtransurethral prostatectomy bladder stones with benign prostatic hyperplasia: report of 120 cases显示文摘 | Chtourou M Ben Younes A Binous MY etal | 2001 | J Endourol2001，15，8： | 1 |
| 13 | Combination of ballistic lithotripsy and transurethral prostatectomy in bladder stones with benign prostatic hyperplasia:report of 120 cases 显示文摘 | Chtourou M Ben Younes A Binous MY | 2001 | J Endourol2001，15，8： | 1 |
| 14 | Combination of ballistic lithotripsy and transurethral prostatectomy in bladder stones with benign prostatic hyperplasia:report of 120 cases显示文摘 | Chtourou M Ben Younes A Binous MY | | 0，，08： | 1 |
| 15 | Combination of ballistic lithatripsy and transurethral prostatectomy in bladder stones with benign prostatic hyperplasia: report of 120 eases显示文摘 | CHTOUROU M BEN YOUNES A BINOUS MY | 2001 | J Endourol2001，15，8： | 1 |
| 16 | Combination of ballisticlithotripsy and transurethral prostatectomy in bladder stones with benignprostatic hyperplasia:report of 120 cases显示文摘 | Chtourou M Ben Younes A Binous MY | 2001 | J Endourol2001，15，8： | 1 |
| 17 | Combination of bal- listic lithotripsy and transurethral prostatectomy bladder stones with benign prostatic hyperplasia: report of 120 cases 显示文摘 | Chtourou M Ben Younes A Binous MY | 2001 | Endouro|2001，15，8： | 1 |
| 18 | Sclerotherapy of idiopat- ic hydrocele with polidocanol: a study about 190 cases 显示文摘 | Sallami S Binous MY Ben Rhouma S | 2011 | Tunis Med2011，89，5： | 1 |
| 19 | Combination of ballistic lithotripsy and transurethral prostatectomy bladder stones with benign prostatic hyperplasia:report of 120 cases 显示文摘 | Chtourou M Ben Younes A Binous MY | 2001 | J Endourol2001，15，8： | 1 |
| 20 | Combination of ballistic lithotripsy and transurethral prostatectomy in bladder stones with benign prostatic hyperplasia:report of 120 cases显示文摘 | Chtourou M Ben Younes A Binous MY | 2013 | JEndourol2013，21，7： | 1 |
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