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| 1 | Parenchyma-sparing pancreatectomies for benign or border-line tumors of the pancreas显示文摘Standard pancreatic resections, such as pancreaticoduodenectomy, distal pancreatectomy, or total pancreatectomy, result in an important loss of normal pancreatic parenchyma and may cause impairment of exocrine and endocrine function. Whilst these procedures are mandatory for malignant tumors, they seem to be too extensive for benign or border-line tumors, especially in patients with a long life expectancy. In recent years, there has been a growing interest in parenchyma-sparing pancreatic surgery with the aim of achieving better functional results without compromising oncological radicality in patients with benign, border-line or low-grade malignant tumors. Several limited resections have been introduced for isolated or multiple pancreatic lesions, depending on the location of the tumor: central pancreatectomy, duodenum-preserving pancreatic head resection with or without segmental duodenectomy, inferior head resection, dorsal pancreatectomy, excavation of the pancreatic head, middle-preserving pancreatectomy, and other multiple segmental resections. All these procedures are technically feasible in experienced hands,with very low mortality, although with high morbidity rate when compared to standard procedures. Pancreatic endocrine and exocrine function is better preserved with good quality of life in most of the patients, and tumor recurrence is uncommon. Careful patient selection and expertise in pancreatic surgery are crucial to achieve the best results. | Cosimo Sperti Valentina Beltrame Anna Caterina Milanetto Margherita Moro Sergio Pedrazzoli | 2010 | World Journal of Gastrointestinal Oncology2010，2，6： | 11 |
| 2 | Para-aortic node involvement is not an independent predictor of survival after resection for pancreatic cancer显示文摘AIM To analyze the importance of para-aortic node status in a series of patients who underwent pancreaticoduodenectomy(PD)in a single Institution.METHODS Between January 2000 and December 2012,151patients underwent PD with para-aortic node dissection for pancreatic adenocarcinoma in our Institution.Patients were divided into two groups:patients with negative PALNs(PALNs-),and patients with metastatic PALNs(PALNs+).Pathologic factors,including stage,nodal status,number of positive nodes and lymph node ratio,invasion of para-aortic nodes,tumor’s grading,and radicality of resection were studied by univariate and multivariate analysis.Survival curves were constructed with Kaplan-Meier method and compared with Log-rank test:significance was considered as P<0.05.RESULTS A total of 107 patients(74%)had nodal metastases.Median number of pathologically assessed lymph nodes was 26(range 14-63).Twenty-five patients(16.5%) had para-aortic lymph node involvement.Thirty-three patients(23%)underwent R1 pancreatic resection.Onehundred forty-one patients recurred and died for tumor recurrence,one is alive with recurrence,and 9 are alive and free of disease.Overall survival was significantly influenced by grading(P=0.0001),radicality of resection(P=0.001),stage(P=0.03),lymph node status(P=0.04),para-aortic nodes metastases(P=0.02).Multivariate analysis showed that grading was an independent prognostic factor for overall survival(P=0.0001),while grading(P=0.0001)and radicality of resection(P=0.01)were prognostic parameters for disease-free survival.Number of metastatic nodes,node ratio,and para-aortic nodes involvement were not independent predictors of disease-free and overall survival.CONCLUSION In this experience,lymph node status and para-aortic node metastases were associated with poor survival at univariate analysis,but they were not independent prognostic factors. | Cosimo Sperti Mario Gruppo Stella Blandamura Michele Valmasoni Gioia Pozza Nicola Passuello Valentina Beltrame Lucia Moletta | 2017 | World Journal of Gastroenterology2017，23，24： | 5 |
| 3 | Potential mechanisms of the acute coronary syndrome presentation in patients with the coronary slow flow phenomenon — Insight from a plasma proteomic approach显示文摘 | Victoria A. Kopetz Megan A.S. Penno Peter Hoffmann David P. Wilson John F. Beltrame | 2011 | International Journal of Cardiology2011，，1： | 2 |
| 4 | Low platelet count: Predictor of death and graft loss after liver transplantation显示文摘BACKGROUND The impact of platelets on liver transplantation(LT) is well recognized, but not completely understood. Platelets exert dichotomous effects on the graft and on the patient. On the one hand, they are essential for primary hemostasis and tissue repair and regeneration. On the other hand, they support ischemia/reperfusion injury and inflammatory processes. Recent evidence has shown a new role for platelet count(PC) in predicting outcomes after LT.AIM To evaluate if low PC is a predictor of short-and long-term outcomes after LT.METHODS Four hundred and eighty consecutive LT patients were retrospectively assessed.PC from the preoperative to the seventh postoperative day(POD) were considered. C-statistic analysis defined the ideal cutoff point for PC. Cox regression was performed to check whether low PC was a predictor of death,retransplantation or primary changes in graft function within one year after LT.RESULTS The highest median PC was 86 × 109/L [interquartile range(IQR) = 65–100 ×109/L] on seventh POD, and the lowest was 51 × 109/L(IQR = 38–71 × 109/L) on third POD. The C-statistic defined a PC < 70 × 109/L on fifth POD as the ideal cutoff point for predicting death and retransplantation. In the multivariate analysis, platelets < 70 × 109/L on 5 POD was an independent risk factor for death at 12 mo after LT [hazard ratio(HR) = 2.01; 95% confidence interval(CI) 1.06-3.79;P = 0.031]. In the Cox regression, patients with PC < 70 × 109/L on 5 POD had worse graft survival rates up to one year after LT(HR = 2.76; 95%CI 1.52-4.99; P =0.001).CONCLUSION PC < 70 × 109/L on 5 POD is an independent predictor of death in the first year after LT. These results are in agreement with other studies that indicate that low PC after LT is associated with negative outcomes. | Pedro Beltrame Santiago Rodriguez Ajacio Bandeira de Mello Brand?o | 2019 | World Journal of Hepatology2019，11，1： | 2 |
| 5 | Coronary hemodynamic and metabolic studies of the coronary slow flow phenomenon显示文摘 | John F Beltrame Sananand B Limaye Ronald D Wuttke John D Horowitz | 2003 | American Heart Journal2003，，： | 1 |
| 6 | Impact strength of nogueira-pecawood on different moisture conditions显示文摘 | Beltrame R Mattos B D Gatto D A | 2012 | Ciencia Rural2012，42，9： | 1 |
| 7 | Characterization of hair(wool)ker-atin intermediate filament gene domain显示文摘 | PoweU B C Beltrame J S | 1994 | J Invest Dermatol1994，102，： | 1 |
| 8 | Role for interactions between IP-10/MIG and CXCR3 in proliferative glomerulonephritis显示文摘 | Beltrame C Annunziato F | 1999 | J Am Soc Nephrol1999，10，： | 1 |
| 9 | Upwardly mobile proteins, workshop: the role of HMG protein in chromatin structure gene expression and neoplasia显示文摘 | Branchi M E Beltrame M | 2000 | EMBO Rep2000，1，12： | 1 |
| 10 | The role of nitric oxide in the coronary slow flow phenomenon 显示文摘 | Beltrame JF Cutri N Kopetz V | 2014 | Coron Artery Dis2014，25，3： | 1 |
| 11 | Terahertz semiconductor-heterostructure laser显示文摘 | K?hler R Tredicucci A Beltram F | | 0，，6885： | 1 |
| 12 | Trauma of the lacrimal drainage system: retrospective study of 32 patients 显示文摘 | Drnovsek- olup B Beltram M | 2004 | CroatMedJ2004，45，： | 1 |
| 13 | The coronary slow flow phenomenon-a new coronary microvascular disorder显示文摘 | Beltrame JF Limaye SB Horowitez JD | 2002 | Cardiology2002，97，4： | 1 |
| 14 | Corneal topographic changes induced by different oblique cataract incisions显示文摘 | Beltrame G Salvetat ML Chizzolini M | 2001 | J Cataract Refract Surg2001，27，5： | 1 |
| 15 | Efect of incision size and site on corneal endothelial changes in cataract surgery显示文摘 | Beltrame G Salvetat M Driussi G | 2002 | J Cataract Refract Surg2002，28，4： | 1 |
| 16 | Trauma of the lacrimal drainage system : Retrospective study of 32 patients 显示文摘 | Drnorvsek - O/up B Beltram M | 2004 | Croat Med J2004，45，3： | 1 |
| 17 | Specific recognition of cruciform DNA by nuclear protein HMG1显示文摘 | Branchi M E Beltrame M Paonessa G | 1989 | Science1989，243，48941： | 1 |
| 18 | Sonographic evaluation of bone fractures:a reliable alternative in clinical practice显示文摘 | Beltrame V Stramare R Rebellato N | 2012 | Clin Imaging2012，36，3： | 1 |
| 19 | Vitamin B12-induced spermatogenesis recovery in cimetidine-treated rats: effect on the spermatogonia number and sperm concentration显示文摘H 2-receptor 对手 cimetidine 是也由于它的 antiangiogenic 效果为癌症的治疗使用的 antiulcer 药。然而,这药在生精的小管引起了结构的变化。维生素 B 12 为男不孕的治疗被用作一个治疗学的代理人。有维生素 B 12 的老鼠的补充在 cimetidine 治疗期间恢复了损坏生精的小管,但是这维生素怎么恢复生精的上皮,没被澄清。在这研究,我们评估了维生素 B 12 是否在对待 cimetidine 的老鼠改进 spermatogonia, spermatocytes,和精子集中的数字。成年雄的老鼠如下被对待 50 天:cimetidine 组收到了 cimetidine 的 100 mg kg 1 b.w, cimetidine-B 12 组收到了 cimetidine 和 12 组收到了的维生素 B 12-hydroxocobalamin, B 的 3 g 仅仅维生素的 3 g,和控制组收到了盐。精子集中被计算,嵌入 historesin 的睾丸节被用于 spermatogonia 的量的分析(一;In/B ) 并且 spermatocytes。TUNEL 方法和 PCNA immunofluorescence 被执行。Cimetidine 在精子集中引起了重要减小。TUNEL 积极的 spermatogonia 和 spermatocytes 在这些房间的数字被相关到重要减小。在 cimetidine-B 12 组,精子集中比在 spermatogonia (阶段 II-VI ) 的数字的 cimetidine 组和重要增加被相关到 PCNA-immunolabeled spermatogonia 和 spermatocytes 的高发生的高。结果证明有维生素 B 12 的老鼠的补充在 cimetidine 处理期间增加精子集中并且在 spermatogonia 和 spermatocytes 的恢复施加潜在的效果。 | Flavia L Beltrame Estela Sasso-Cerri | 2017 | Asian Journal of Andrology2017，19，5： | 1 |
| 20 | Hyperpolarization-activated cyclic nucleotide-gated channel 1 is a molecular determinant of the cardiac pacemaker current显示文摘 | Moroni A Gorzai L Beltrame M | 2001 | J Biol Chem2001，276，29： | 1 |
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