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| 1 | Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis显示文摘AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.RESULTS:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). CONCLUSION:In patients with alcoholic liver cirrhosis,the-2518 MCP-1 genotype AA is a risk factor for the development of SBP. | Erwin Gbele Marcus Mhlbauer Hartwig Paulo Monika Johann Christin Meltzer Franz Leidl Norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand | 2009 | World Journal of Gastroenterology2009，15，44： | 7 |
| 2 | Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis显示文摘AIM: To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level. METHODS: Fat fed rats were used as a model for fatty liver disease and bile duct ligation in mice to investigate cirrhotic liver. Expression of AdipoR1 and AdipoR2 mRNA was determined by real time RT-PCR. AdipoR1 protein was analysed by immunoblot. Adiponectin was measured by ELISA. RESULTS: Systemic adiponectin is reduced in fat- fed rats but is elevated in mice after bile duct ligation (BDL). Hepatic adiponectin protein is lower in steatotic liver but not in the liver of BDL-mice when compared to controls. Adiponectin mRNA was not detected in human liver samples or primary human hepatocytes nor in rat liver but recombinant adiponectin is taken up by isolated hepatocytes in-vitro. AdipoR1 mRNA and AdipoR1 protein levels are similar in the liver tissue of control and fat fed animals whereas AdipoR2 mRNA is induced. AdipoR2 mRNA and AdipoR1 mRNA and protein is suppressed in the liver of BDL-mice. CONCLUSION: Our studies show reduced circulating adiponectin in a rat model of fatty liver disease whereas circulating adiponectin is elevated in a mouse model of cirrhosis and similar fi ndings have been described in humans. Diminished hepatic expression of adiponectinreceptors was only found in liver cirrhosis. | Markus Neumeier Claus Hellerbrand Erwin Gbele Roland Buettner Cornelius Bollheimer Johanna Weigert Andreas Schffler Thomas S Weiss Monika Lichtenauer Jürgen Schlmerich Christa Buechler | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 3 | Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension显示文摘AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90. | Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 4 | Towards high-power, high-coherence, integrated photonic mm Wave platform with microcavity solitons显示文摘Millimetre-wave(mmWave)technology continues to draw great interest due to its broad applications in wireless communications,radar,and spectroscopy.Compared to pure electronic solutions,photonic-based mmWave generation provides wide bandwidth,low power dissipation,and remoting through low-loss fibres.However,at high frequencies,two major challenges exist for the photonic system:the power roll-off of the photodiode,and the large signal linewidth derived directly from the lasers.Here,we demonstrate a new photonic mmWave platform combining integrated microresonator solitons and high-speed photodiodes to address the challenges in both power and coherence.The solitons,being inherently mode-locked,are measured to provide 5.8 dB additional gain through constructive interference among mmWave beatnotes,and the absolute mmWave power approaches the theoretical limit of conventional heterodyne detection at 100 GHz.In our free-running system,the soliton is capable of reducing the mmWave linewidth by two orders of magnitude from that of the pump laser.Our work leverages microresonator solitons and high-speed modified uni-traveling carrier photodiodes to provide a viable path to chip-scale,high-power,low-noise,high-frequency sources for mmWave applications. | Beichen Wang Jesse SMorgan Keye Sun Mandana Jahanbozorgi Zijiao Yang Madison Woodson Steven Estrella Andreas Beling Xu Yi | 2021 | Light(Science & Applications)2021，10，1： | 3 |
| 5 | High-performance modified uni-traveling carrier photodiode integrated on a thin-film lithium niobate platform显示文摘Lithium niobate on insulator(LNOI)has become an intriguing platform for integrated photonics for applications in communications,microwave photonics,and computing.Whereas,integrated devices including modulators,resonators,and lasers with high performance have been recently realized on the LNOI platform,high-speed photodetectors,an essential building block in photonic integrated circuits,have not been demonstrated on LNOI yet.Here,we demonstrate for the first time,heterogeneously integrated modified uni-traveling carrier photodiodes on LNOI with a record-high bandwidth of 80 GHz and a responsivity of 0.6 A/W at a 1550-nm wavelength.The photodiodes are based on an n-down In GaAs/InP epitaxial layer structure that was optimized for high carrier transit time-limited bandwidth.Photodiode integration was achieved using a scalable wafer die bonding approach that is fully compatible with the LNOI platform. | XIANGWEN GUO LINBO SHAO LINGYAN HE KEVIN LUKE JESSE MORGAN KEYE SUN JUNYI GAO TA-CHING TZU YANG SHEN DEKANG CHEN BINGTIAN GUO FENGXIN YU QIANHUAN YU MASOUD JAFARI MARKO LONčAR MIAN ZHANG ANDREAS BELING | 2022 | Photonics Research2022，10，6： | 2 |
| 6 | Porous olivine composites synthesized by sol-gel technique 显示文摘 | DOMINKO R BELE M GABERSCEK M | 2006 | J Power Sources2006，153，2： | 1 |
| 7 | Incorporation andrelease of drug into/from superparamagnetic iron oxide nanoparti-cles显示文摘 | MAVER U BELE M MAKOVEC I) | 2009 | Journal of Magnetism and Magnetic Materials2009，321，19： | 1 |
| 8 | Critical comparison of emission spectroscopic determination of dissociation in hydrogen RF discharges显示文摘 | Gathen V S D(o)bele H F | 1996 | Plasma Chem Plasma Proc1996，16，： | 1 |
| 9 | Structural ceramic coatings in composite microtruss cellular materials 显示文摘 | BELE E BOUWHUIS B A CODD C HIBBARD G D | 2011 | Acta Mater2011，59，15： | 1 |
| 10 | Porous olivine composites synthesized by sol-gel technique 显示文摘 | DOMINKO R BELE M GABERSCEK M REMSKAR M HANZEL D GOUPIL J M PEJOVNIK S JAMNIK J | 2006 | J Power Sources2006，153，2： | 1 |
| 11 | Neuropeptide Y - an early biomarker for cerebral vasospasm after aneurysmal subarachnoid hemorrhage显示文摘 | Schebesch KM Brawanski A Bele S | 2013 | Neurol Res2013，35，10： | 1 |
| 12 | Defect Study of Zn-Doped p-Type Gallium Antimonide using Positron Lifetime Spectroscopy显示文摘 | Ling C C Fung S Beling C D at al | 2001 | Phys Rev B2001，64，07： | 1 |
| 13 | Porous,carbon-decorated LiFePO4 prepared by sol-gel method based on citric acid显示文摘 | GABERSCEK M DOMINKO R BELE M REMSKAR M HANZEL D JAMNIK J | 2005 | Solid State Ionics2005，176，： | 1 |
| 14 | Li2MnSiO4 as a potential Li-bat- tery cathode material显示文摘 | Dominko R Bele M Kokalj A | 2007 | J Power Sources2007，174，2： | 1 |
| 15 | Diagnostic accuracy ofprocalcitonin in critically ill immunocompromised patients 显示文摘 | Bele N Darmon M Coquet I | 2011 | BMC Infect Dis2011，11，： | 1 |
| 16 | Impact of the car- bon coating thickness on the electrochemical performance of LiFePOJC composites显示文摘 | DOMINKO R BELE M GABERSCEK M | 2005 | Journal of the Electrochemical Society2005，152，3： | 1 |
| 17 | Electron-irradiation-induced deep levels in n-type 6 H-SiC显示文摘 | Gong M Fung S Beling C D | 1999 | J Appl Phys1999，85，11： | 1 |
| 18 | Structure and electrochemical performance of Li2MnSiO4 and Li2FeSiO4 as potential Li-battery cathode materials 显示文摘 | DOMINKO R BELE M GABERSCEK M | 2006 | Electrochem Comrnun2006，，8： | 1 |
| 19 | Impact of the carbon coating thickness on the electrochemical per{orrnance of LiFePO4/C composites 显示文摘 | Dominko R Bele M Gaberscek M | 2005 | Electrochem Soc2005，152，3： | 1 |
| 20 | Influence of acetylene black distribution on performance of oxide cathodes for l,i ion batteries 显示文摘 | Dominko R Gaberscek M Drofenik J Bele M Jamnik J | 2005 | Electrochim Acta2005，48，： | 1 |
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