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| 1 | Preliminary study on modelling, fabrication by photo-chemical etching and in vivo testing of biodegradable magnesium AZ31 stents显示文摘Magnesium metal(Mg)is a promising material for stent applications due to its biocompatibility and ability to be resorbed by the body.Manufacturing of stents by laser cutting has become an industry standard.Our alternative approach uses photo-chemical etching to transfer a pattern of the stent onto a Mg sheet.In this study,we present three stages of creating and validating a stent prototype,which includes design and simulation using finite element analysis(FEA),followed by fabrication based on AZ31 alloy and,finally,in vivo testing in peripheral arteries of domestic pigs.Due to the preliminary character of this study,only six stents were implanted in two domestic farm pigs weighing 25-28 kg and they were evaluated after 28 days,with an interim follow-up on day 14.The left and right superficial femoral,the left iliac,and the right renal artery were selected for this study.The diameters of the stented artery segments were evaluated at the time of implantation,on day 14 and then,finally,on day 28,by quantitative vessel analysis(QVA)using fluoroscopic imaging.Optical Coherence Tomography(OCT)imaging displayed some malposition,breaks,stacking,and protrusion into the lumen at the proximal,distal,and mid-sections of the stented arteries.The stents degraded with time,but simultaneously became embedded in the intima.After 28 days,the animals were euthanized,and explanted vessels were fixed for micro-CT imaging and histology studies.Micro-CT imaging revealed stent morphological and volumetric changes due to the in-body degradation.An in vivo corrosion rate of 0.75 mm/year was obtained by the CT evaluation.The histology suggested no-life threatening effects,although moderate injury,inflammation,and endothelialization scores were observed. | Bala Subramanya Pavan Kumar Kandala Guangqi Zhang Capucine LCorriveau Mark Paquin Madeleine Chagnon Dana Begun Vesselin Shanov | 2021 | Bioactive Materials2021，6，6： | 2 |
| 2 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 3 | Production of L-lactic acid by immobilized cells of Production oryzae prepared by γ-ray induced polymerization显示文摘 | Tamada M Begun A A Sadi A | 1992 | Biotechnol Bioeng1992，74，6： | 1 |
| 4 | Particle number fluctuations in relativistic Bose and Fermi gases显示文摘 | Begun V V Gorenstein M I | 2006 | Phys Rev C2006，73，05： | 1 |
| 5 | The role of Rho GTPases in the regulation of the rearrangement of actin cytoskeleton and cell movement显示文摘 | Begun R Nur-E-Kamal MS Zaman MA | 2004 | Exp Mol Med2004，36，4： | 1 |
| 6 | The worm has turned-microbial virulence modeled in Caenorhabditis elegans显示文摘 | COSTI D SIFRI JAKOB BEGUN AUSUBEL FREDERICK M | 2005 | TRENDS in Microbiology2005，13，3： | 1 |
| 7 | Risk factors in German twins with inflammatory bowel disease: Results of a questionnaire-based survey显示文摘 | Martina E. Spehlmann Alexander Z. Begun Ekaterini Saroglou Frank Hinrichs Ute Tiemann Andreas Raedler Stefan Schreiber | 2011 | Journal of Crohn’s and Colitis2011，，1： | 1 |
| 8 | Factors associated with low birth weight in rural Bangiadesh显示文摘 | Hosain GM Chatterjee N Begun A | 2006 | J Trop Pediat2006，52，2： | 1 |
| 9 | Study of Disease Progression and Relevant Risk Factors in Diabetic Foot Patients Using a Multistate Continuous-Time Markov Chain Model显示文摘 | Begun A Morbach S tkiimenapf G | 2016 | PLoS One2016，11，01： | 1 |
| 10 | The effects of axial displacement on fracture callus morphology and MSC homing depend on the timing of application显示文摘 | Weaver AS Su Yu-ping Begun DL | 2010 | Bone2010，47，1： | 1 |
| 11 | Modes of intracorporeal lithotripsy : ultrasound versus electro- hydraulic lithotripsy versus laser lithotripsy显示文摘 | Begun FP | 1994 | Semin Urol1994，12，： | 1 |
| 12 | Estimating the relative risk with censored data显示文摘 | REID N | 1983 | J Am Stat Ass1983，78，： | 1 |
| 13 | Knowledge and attitude towards voluntary blood donation among Dhaka University students in Bangladesh显示文摘 | Hosain Gm Anisuzzam M Begun A | 1997 | East Afrmed J1997，74，9： | 1 |
| 14 | Information and asymptotic exigency in parametric-nonparametic models显示文摘 | Begun J B Hall W J Huang W M | 1983 | The Annals of Statistics1983，11，： | 1 |
| 15 | Modes of intracorporeal lithotripsy: ultrasound versus electro- hydraulic lithotripsy versus laser lithotripsy显示文摘 | Begun FP | 1994 | Semin Urol1994，12，： | 1 |
| 16 | Opportunities for improving patient care through lateral integration:the clinical nurse leader显示文摘 | Begun JW Tornabeni J White KR | 2006 | Journal of Healthcare Management2006，51，1： | 1 |
| 17 | Epidemiology of inflammatory bowel disease in a german twin cohort: results of a nationwide study 显示文摘 | Spehlmann ME Begun AZ Burghardt J | 2008 | Inflamm Bowel Dis2008，14，7： | 1 |
| 18 | Patient evaluation,laboratory and imaging studies显示文摘 | Foley WD Peterson A | 1997 | Urol Clin North Am1997，24，： | 1 |
| 19 | Regional concentration of basc fibroblast growth factor in normal and benign hyperplastic human prostates 显示文摘 | Story MT Hopp KA | 1995 | J Urol1995，153，： | 1 |
| 20 | Regional concentration of basic fibroblast growth factor in normal and benign hyperplastic human prostates 显示文摘 | Story MT Hopp KA | 1995 | J Urol1995，153，： | 1 |
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