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| 1 | 急性冠状动脉综合征发生1个月后的生长分化因子15水平与主要出血风险增加相关显示文摘用双重抗血小板治疗的急性冠状动脉综合征(acutecoronarysyndromes,ACS)患者在初次就诊测量的生长分化因子15(growthdifferentiationfactor-15,GDF-15)与大出血相关。 | Lindholm D Hagstrm E James SK Becker RC Cannon CP Himmelmann A Katus HA Maurer G López-Sendón JL Steg PG Storey RF Siegbahn A Wallentin L 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 5 |
| 2 | Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer显示文摘AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal cancer.METHODS Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival outcomes.RESULTS While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing. | Daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh Kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M Becker | 2018 | World Journal of Gastroenterology2018，24，7： | 5 |
| 3 | The cost of hospitalization in Crohn’s disease显示文摘 | Russell D Cohen Leanne R Larson Joel M Roth Russell V Becker Lisa L Mummert | 2000 | The American Journal of Gastroenterology2000，，2： | 2 |
| 4 | Analysis of protein solvent accessible surfaces by photochemical oxidation and mass spectrometry显示文摘 | SHARP J S BECKER J M HETTICH R L | | 0，，3： | 1 |
| 5 | Effects of transition season management on soil N dynamics and system N balances in rice-wheat rotations of Nepal显示文摘 | Becker M Asch F Maskey S L | 2007 | Field Crops Research2007，103，： | 1 |
| 6 | I-dentification of a cytotoxic T lymphocyte response to the apoptosis inhibitor protein Survivin in cancer patients 显示文摘 | ANDERSEN M H PEDERSEN L O BECKER J C | 2001 | Cancer Res2001，61，3： | 1 |
| 7 | Human follicle- stimulating hormone beta -subunit gene encodes multiple messenger ribonucleic acids显示文摘 | Jameson J L Becker C B Lindell C M | 1958 | Mol Endocrinol1958，2，9： | 1 |
| 8 | Familial trends of obesity through three generations : the Belgian-Luxembourg child study 显示文摘 | Guillaume M Lapidus L Beckers F | 1995 | Int J Obes Relat Metab Disord1995，193，： | 1 |
| 9 | Middle east respiratory syndrome eoronavirus spike protein delivered by modified vaccinia virus ankara effi- ciently induces virus-neutralizing antibodies显示文摘 | Song F Fux R Provacia L B Volz A Eickmann M Becker S Osterhaus A D Haagmans B L Sutter G | 2013 | J Vir ol2013，87，11： | 1 |
| 10 | Pregabalin is effective against behavioral and electrographic seizures during alcohol withdrawal 显示文摘 | Becker H C Myrick H Veatch L M | 2006 | Alcohol Alcoholism2006，41，1： | 1 |
| 11 | Febuxostat,a novel nonpurine selective inhibitor of xanthine oxidase:a twenty-eight-day,multicenter,phase Ⅱ,randomized,double-blind,placebo-controlled,dose-response clinical trial examining safety and efficacy in patients with gout显示文摘 | Becker M A Schumacher H R Jr Wortmann R L | | 0，，03： | 1 |
| 12 | Determination of sulphonamides in pork meat extracts by capillary zone electrophoresis 显示文摘 | Ackermans M T J L Beckers F M Everaerts | 1992 | Journal of Chromatography A1992，596，1： | 1 |
| 13 | Burnout, depression, and career satisfaction: Cross--sectional study of obstetrics and gynecology residents显示文摘 | Becker J L Milad M P Ktock S C | 2006 | 195(5) :1444-14492006，195，5： | 1 |
| 14 | The PULSE initiative: scientific priorities and strategic planning for resuscitation research and life saving therapies 显示文摘 | Becker L B Weisfeldt M L Weil M H | 2002 | Circulation2002，105，21： | 1 |
| 15 | Driving factors of the phytoplankton functional groups in a deep Mediterranean reservoir显示文摘 | Becker V Caputo L Ordoniez J Marc6 R Armengol J Crossetti L O Huszar V L M | 2010 | Water Research2010，44，： | 1 |
| 16 | Responses of phytoplankton functional groups to the mixing regime in a deep subtropical reservoir显示文摘 | Becker V Huszar V L M Crossetti L O | 2009 | Hydrobiologia2009，628，： | 1 |
| 17 | Emergency medical services in the reconstruction phase following a major earthquake: A case study of the 1988 Armenia earthquake显示文摘 | Handrlgan M T Becker B M Jagminas L | 1998 | Prehospital Disaster Med1998，13，1： | 1 |
| 18 | Dis- ordered calcium homeostasis of sepsis: association with calcitonin precursors 显示文摘 | MULLER B BECKER K L KRANZLIN M | 2000 | Eur J Clin Invest2000，30，9： | 1 |
| 19 | Febuxostat compared with allopurinol in patients with hyperuricemia and gout显示文摘 | Becker M A Schumacher H R Jr Wortmann R L | | 0，，23： | 1 |
| 20 | Cold-induced putative DEAD box RNA helicases CshA and CshB are essential for cold adaptation and interact with Cold Shock Protein B in Bacillus subtilis显示文摘 | Hunger K Beckering C L Wiegeshoff F Graumann P L Marahiel M A | 2006 | Journal of Bacteriology2006，188，1： | 1 |
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