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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Genetic and cellular mechanisms in chromium and nickel carcinogenesis considering epidemiologic findings显示文摘 | Chiu A Katz A J Beaubier J | 2004 | Molecular and Cellubar Biochemistry2004，255，1： | 1 |
| 3 | Gastric cancer and trastuzumab: first biologic therapy in gastric cancer显示文摘 | Gunturu KS Woo Y Beaubier N | 2013 | Ther Adv Med Oncol2013，5，2： | 1 |
| 4 | Comparison of capillary electrophoresis and polyacrylamide gel electrophoresis for the evaluation of T and B cell clonality by polymerase chain reaction显示文摘 | Beaubier NT Hart AP Bartolo C | 2000 | Diagn Mol Pathol2000，9，3： | 1 |
| 5 | Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study显示文摘 | Tong G X Yu W M Beaubier N T | 2009 | Mod Pathol2009，22，9： | 1 |
| 6 | Overexpression of toll-like receptor 4 amplifies the host response to lipopolysaccharide and provides a survival advantage in transgenic mice显示文摘 | Bihl F Salez L Beaubier M | 2003 | J Immunol2003，170，： | 1 |
| 7 | Genetic and cellular mechanisms in chromium and nickel carcinogenesis considering epidemiologic findings显示文摘 | Chiu A Katz AJ Beaubier J | 2004 | MolCellBiochem2004，255，12： | 1 |
| 8 | Genetic and Cellu- lar Mechanisms in Chromium and Nickel Carcinogenesis Consid- ering Epidemiologic Findings 显示文摘 | CHIU A KATZ A J BEAUBIER J | 2004 | Mol Cell Biochem2004，255，12： | 1 |
| 9 | Combining Drosophila melanogaster somatic-mutation-recombination and electron-spinresonance-spectroscopy data to interpret epidemiologic observations on chromium carcinogenicity显示文摘 | RaTz AJ Chin A Beaubier J | 2001 | Mol Cell Biochem2001，222，12： | 1 |
| 10 | Combining Drosophila melanogaster somatic-mutation-recombination and electronspin resonance spectro-scopy data to interpret epidemiologic observations on chromium carcinogenicity 显示文摘 | Katz A Chiu A Beaubier J | 2001 | Mol Cell Biochem2001，222，： | 1 |
| 11 | Genetic and cellular mechanisms in chromium and nickel carcinogenesis con- sidering epidemiologic findings 显示文摘 | CHIU A KATZ A J BEAUBIER J | 2004 | Molecular and Cellular Biochemistry2004，255，1： | 1 |
| 12 | Overexpression of toll-like receptor 4 amplifies the host response to lipopolysaccharide and provides a survival advantage in transgenic mice显示文摘 | Bihl F Salez L Beaubier M Tones D Larivière L Laroche L Benedetto A Martel D Lapointe J M Ryffel B Malo D | | 0，，： | 1 |
| 13 | Overexpression of toll-like receptor 4amplifies the host response to lipopolysaccharide and provides a survival advantage in transgenic mice显示文摘 | Bihl F Salez L Beaubier M | 2003 | J Immunol2003，170，12： | 1 |
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